Abstract:
:The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selection of their MHC class I ligands. Human KIR diversity is now a burgeoning area for disease association studies. This review examines the evolution of KIR from a primate-centric view in order to rationalize our current knowledge of the diversity of human KIR.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Martinez-Borra J,Khakoo SIdoi
10.1111/j.1744-313X.2008.00756.xsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
89-96issue
2eissn
1744-3121issn
1744-313Xpii
EJI756journal_volume
35pub_type
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