当前位置： SCI文献检索 > International Journal of Immunogenetics期刊下所有文献 > HLA class II eplet mismatch load improves prediction of dnDSA development after living donor kidney transplantation.

HLA class II eplet mismatch load improves prediction of dnDSA development after living donor kidney transplantation.

Abstract：

:HLA donor-specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA development after living donor kidney transplantation (LDKT). We retrospectively analysed a cohort of 96 LDKT between 2008 and 2017 performed in Hospital Santo António. Seven patients developed dnDSA-II and EpvMM and EptMM were greater in dnDSA-II group compared to the no dnDSA-II (18.0 ± 8.7 versus 9.9 ± 7.9, p = .041 and 41.3 ± 18.9 versus 23.1 ± 16.7, p = .018), which is not observed for AgMM (2.29 versus 1.56; p = .09). In a multivariate analysis, we found that preformed DSA (HR = 7.983; p = .023), living unrelated donors (HR = 8.052; p = .024) and retransplantation (HR = 14.393; p = .009) were predictors for dnDSA-II (AUC = 0.801; 0.622-0.981). HLA-II EpvMM (HR = 1.105; p = .028; AUC = 0.856) showed to be a superior predictor of dnDSA-II, when compared to AgMM (HR = 1.740; p = .113; AUC = 0.783), when adjusted for these clinical variables. Graft survival was significantly lower within dnDSA-II patient group (36% versus 88%, p < .001). HLA molecular mismatch analysis is extremely important to minimize risk for HLA-II dnDSA development improving outcome and increasing chance of retransplant lowering allosensitization.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Tafulo S,Malheiro J,Santos S,Dias L,Almeida M,Martins S,Pedroso S,Mendes C,Lobato L,Castro-Henriques A

doi

10.1111/iji.12519

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

1-7

issue

1

eissn

1744-3121

issn

1744-313X

journal_volume

48

pub_type

杂志文章

相关文献

International Journal of Immunogenetics文献大全
  • Association of tumour necrosis factor-alpha -308 G/A promoter polymorphism with susceptibility and disease profile of rheumatoid arthritis.

    abstract：:The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in the susceptibility and/or the disease profile of rheumatoid arthritis (RA) in Egyptian patients. TNF-α-308 G/promoter polymorphism detection by amplification refractory mutation system (ARMS)...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01028.x

    authors： Mosaad YM,Abdelsalam A,El-Bassiony SR

    更新日期：2011-10-01 00:00:00

  • Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non-coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem).

    abstract：:Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four s...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12423

    authors： Lobo-Alves SC,de Oliveira LA,Petzl-Erler ML

    更新日期：2019-06-01 00:00:00

  • Vascular endothelial growth factor +405 G/C,-460 T/C and -2578 A/C polymorphisms are not associated with insulin resistance in polycystic ovary syndrome.

    abstract：:Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00915.x

    authors： Vural P,Küskü-Kiraz Z,Doğru-Abbasoğlu S,Cil E,Karadağ B,Uysal M

    更新日期：2010-08-01 00:00:00

  • MHC class I polymorphic Alu insertion (POALIN) allele and haplotype frequencies in the Arabs of the United Arab Emirates and other world populations.

    abstract：:Polymorphic Alu insertions (POALINs) are found throughout the human genome and have been used in various studies to infer geographic origin of human populations. The main aim of this study was to determine the allele and haplotype frequencies of five POALINs, AluHF, AluHG, AluHJ, AluTF and AluMICB, within the major hi...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12426

    authors： Kulski JK,Mawart A,Marie K,Tay GK,AlSafar HS

    更新日期：2019-08-01 00:00:00

  • Role of TLR4 C>1196T (Thr399Ile) and TLR4 A>896G (Asp299Gly) polymorphisms in a North Indian population with asthma: a case-control study.

    abstract：:Toll-like receptor 4 (TLR4) is the most important TLR among the pattern recognition receptors which recognizes lipopolysaccharide of gram-negative bacteria. They identify a highly conserved structure of microbes called pathogen-associated molecular patterns and activate immune and inflammatory responses that have been...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12115

    authors： Sinha S,Singh J,Jindal SK,Birbian N,Singla N

    更新日期：2014-12-01 00:00:00

  • ICAM-1 polymorphisms and development of cutaneous malignant melanoma.

    abstract：:Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). ICAM-1 expression is associated with increasing Breslow thickness of vertical growth-phase tumours and, in patients with stage 1 disease, may be associated with disease free...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00539.x

    authors： Howell WM,Rose-Zerilli MJ,Theaker JM,Bateman AC

    更新日期：2005-12-01 00:00:00

  • New genes associated with rheumatoid arthritis identified by gene expression profiling.

    abstract：:In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to com...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12313

    authors： Wang H,Guo J,Jiang J,Wu W,Chang X,Zhou H,Li Z,Zhao J

    更新日期：2017-06-01 00:00:00

  • A chromosomal event resulting in possession and expression of multiple HLA-B and Cw genes in a renal patient.

    abstract：:Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric s...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00610.x

    authors： Poole K,Montague B,Roberts R,Stoves J,Bendukidze N,Clark B

    更新日期：2006-08-01 00:00:00

  • Killer cell immunoglobulin-like receptors on NK cells: the how, where and why.

    abstract：:Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-association studies that KIR receptors can play beneficial roles in viral ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2007.00739.x

    authors： Gardiner CM

    更新日期：2008-02-01 00:00:00

  • HLA-A*11:53 is shown to be identical to the corrected A*11:02:01 allele sequence.

    abstract：:According to the IMGT/HLA Database, the DNA sequence of A*11:53 is identical to A*11:02:01 in exons 2, 3, 4 and 5 except at codon 276. A*11:53 was reported as a rare variant of A*11, while A*11:02:01 was understood to be the second most frequently observed variant of A*11 after A*11:01:01 in Taiwanese. We sequenced HL...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01121.x

    authors： Yang KL,Chu CC,Marsh SG,Lin PY

    更新日期：2012-12-01 00:00:00

  • Mannose-binding lectin and MBL-associated serine protease-2 gene polymorphisms in a Brazilian population from Rio de Janeiro.

    abstract：:Mannose-binding lectin (MBL) is a protein able to bind to carbohydrate patterns on pathogen membranes; upon MBL binding, its' associated serine protease MBL-associated serine protease type 2 (MASP2) is autoactivated, promoting the activation of complement via the lectin pathway. For both MBL2 and MASP2 genes, the freq...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01052.x

    authors： Ferraroni NR,Segat L,Guimarães RL,Brandão LA,Crovella S,Constantino-Silva RN,Loja C,da Silva Duarte AJ,Grumach AS

    更新日期：2012-02-01 00:00:00

  • Association between CCL2 haplotypes and knee osteoarthritis.

    abstract：:We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in t...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12015

    authors： Hulin-Curtis SL,Bidwell JL,Perry MJ

    更新日期：2013-08-01 00:00:00

  • Using ESTs database to predict and validate single polymorphisms at the HLA system.

    abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01076.x

    authors： Figueiredo TC,de Oliveira JR

    更新日期：2012-06-01 00:00:00

  • Solid phase testing in the HLA laboratory: implications for organ allocation.

    abstract：:This piece was originally requested as a white paper from the Scientific and Clinical Affairs Committee of the American Society for Histocompatibility and Immunogenetics (ASHI), of which the author was then Chairman. Upon review by the ASHI Board of Directors and the Editors of their journal, it was considered too con...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2008.00768.x

    authors： Eckels DD

    更新日期：2008-08-01 00:00:00

  • CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions.

    abstract：:Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12444

    authors： Mangieri LFL,Sena MM,Cezar-Dos-Santos F,Trugilo KP,Okuyama NCM,Pereira ÉR,Maria GCQ,Watanabe MAE,de Oliveira KB

    更新日期：2019-10-01 00:00:00

  • Th-1 cytokines gene polymorphism in human brucellosis.

    abstract：:Brucellosis is a worldwide zoonosis. Infection with Brucella species results in the activation of cell-mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possibl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00626.x

    authors： Davoudi S,Amirzargar AA,Hajiabdolbaghi M,Rasoolinejad M,Soodbakhsh A,Jafari S,Piri H,Maleknejad P,Bagherian H,Madadi N,Nikbin B

    更新日期：2006-10-01 00:00:00

  • Intron 4 polymorphism of the endothelial nitric oxide synthase eNOS gene and early microangiopathy in type 1 diabetes.

    abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00839.x

    authors： Mamoulakis D,Bitsori M,Galanakis E,Vazgiourakis V,Panierakis C,Goulielmos GN

    更新日期：2009-06-01 00:00:00

  • Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.

    abstract：:Genes involved in regulation of the nuclear factor - kappa B (NF-κB) pathway are suggested to play a role in the pathogenesis of acute myeloid leukaemia (AML). The present study aimed to assess the association between the NF-κB1, TRAF3 and TLRs genes single nucleotide polymorphisms (SNPs) and disease susceptibility as...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12255

    authors： Rybka J,Gębura K,Wróbel T,Wysoczańska B,Stefanko E,Kuliczkowski K,Bogunia-Kubik K

    更新日期：2016-04-01 00:00:00

  • Association between interferon lambda 3 rs12979860 polymorphism and clinical outcome in dengue virus-infected children.

    abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12477

    authors： da Silva Cezar RD,da Silva Castanha PM,Matos Freire N,Mola C,Feliciano do Carmo R,Tenório Cordeiro M,Baptista P,Silva Vasconcelos LR,Moura P,da Silva Teixeira VG

    更新日期：2020-08-01 00:00:00

  • Characterization of a novel MICB variant in an individual from the Chinese Uyghur population, MICB*005:09, by cloning and sequencing.

    abstract：:A new allelic variant in MICB*005 lineage, MICB*005:09, has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR-sequence-based typing (Sanger sequencing) and confirmed by cloning and sequencing. Aligned with MICB*005:03, this new allelic variant shows a synonymous...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12410

    authors： Tursun M,Wang Z,Guo W,Hasim A,Tian W

    更新日期：2019-02-01 00:00:00

  • Genetic association of interleukin-2, interleukin-4, interleukin-6, transforming growth factor-β, tumour necrosis factor-α and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients.

    abstract：:Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12192

    authors： Seyhun Y,Ciftci HS,Kekik C,Karadeniz MS,Tefik T,Nane I,Turkmen A,Oguz FS,Aydin F

    更新日期：2015-06-01 00:00:00

  • Characterization of HLA-F polymorphism in four distinct populations in Mainland China.

    abstract：:Currently, there is a lack of information on polymorphism of human leucocyte antigen-F (HLA-F) gene in ethnically diverse human populations. In this study, HLA-F allelic typing was performed for 690 individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese pop...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12047

    authors： Pan FH,Liu XX,Tian W

    更新日期：2013-10-01 00:00:00

  • The -1541 C>T and +4259 G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population.

    abstract：:The T-cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to be associated with susceptibility to rheumatoid arthritis (RA). In this study, we investigated the association of four single-nucleotide polymorphisms (SNPs) of the TIM-3 gene with RA susceptibility in Chinese Hui and Han groups. Using restriction ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01046.x

    authors： Xu J,Yang Y,Liu X,Wang Y

    更新日期：2011-12-01 00:00:00

  • Association between FokI, ApaI and TaqI RFLP polymorphisms in VDR gene and Hashimoto's thyroiditis: preliminary data from female patients in Serbia.

    abstract：:Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder caused by an interaction between genes and environmental triggers. Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have sh...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12199

    authors： Djurovic J,Stojkovic O,Ozdemir O,Silan F,Akurut C,Todorovic J,Savic K,Stamenkovic G

    更新日期：2015-06-01 00:00:00

  • HLA gene and haplotype frequencies in Russians, Bashkirs and Tatars, living in the Chelyabinsk Region (Russian South Urals).

    abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01117.x

    authors： Suslova TA,Burmistrova AL,Chernova MS,Khromova EB,Lupar EI,Timofeeva SV,Devald IV,Vavilov MN,Darke C

    更新日期：2012-10-01 00:00:00

  • A clinical case-control study on the association between mannose-binding lectin and susceptibility to HIV-1 infection among northern Han Chinese population.

    abstract：:Mannose-binding lectin (MBL) is a key molecule of the innate immune system and a competent to bind carbohydrates of a variety of microorganisms, resulting in complement activation and opsonophagocytosis against various pathogens. However, there is no systemic investigation on the MBL's role in innate immune responses ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00946.x

    authors： Sheng A,Lan J,Wu H,Lu J,Wang Y,Chu Q,Jia Z,Song M,Liu L,Wang W

    更新日期：2010-12-01 00:00:00

  • HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?

    abstract：:The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2008.00801.x

    authors： Albanidou-Farmaki E,Deligiannidis A,Markopoulos AK,Katsares V,Farmakis K,Parapanissiou E

    更新日期：2008-12-01 00:00:00

  • Distribution of KIR genes in the Czech population.

    abstract：:Killer cells immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed mainly by natural killer (NK) cells and few subsets of T lymphocytes. KIRs regulate NK cells' activity through interactions with specific HLA class I molecules and other yet unknown ligands presented on targ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00737.x

    authors： Pavlova Y,Kolesar L,Striz I,Jabor A,Slavcev A

    更新日期：2008-02-01 00:00:00

  • TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients.

    abstract：:The Toll-like receptors (TLRs) are related to innate immunity. TLR9, a member of TLRs, is expressed in immune cell-rich tissues and mediates cellular response. We investigated the association between TLR9 polymorphisms and kidney allograft outcomes. To investigate whether TLR9 polymorphisms are associated with acute r...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,多中心研究

    doi：10.1111/iji.12069

    authors： Kim TH,Jeong KH,Kim SK,Lee SH,Ihm CG,Lee TW,Moon JY,Yoon YC,Chung JH,Park SJ,Kang SW,Kim YH

    更新日期：2013-12-01 00:00:00

  • Dominant, non-MHC genetic control of food allergy in an adjuvant-free mouse model.

    abstract：:Food allergy is a potentially fatal immune-mediated disorder with incompletely understood mechanisms. We studied the genetic control of food allergy using major histocompatibility complex-identical mice (H2(s)) and an adjuvant-free method of sensitization. Whereas, transdermal exposure to hazelnut - a model allergenic...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00860.x

    authors： Parvataneni S,Birmingham NP,Gonipeta B,Gangur V

    更新日期：2009-10-01 00:00:00