Characterization of a novel MICB variant in an individual from the Chinese Uyghur population, MICB*005:09, by cloning and sequencing.

abstract：:We have used molecular methods to determine the frequencies of human leukocyte antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from North India using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes as there is no comprehensive report showing molecu...

journal_title：International journal of immunogenetics

authors： Rani R,Marcos C,Lazaro AM,Zhang Y,Stastny P

更新日期：2007-06-01 00:00:00

abstract：:Brucellosis is a worldwide zoonosis. Infection with Brucella species results in the activation of cell-mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possibl...

journal_title：International journal of immunogenetics

authors： Davoudi S,Amirzargar AA,Hajiabdolbaghi M,Rasoolinejad M,Soodbakhsh A,Jafari S,Piri H,Maleknejad P,Bagherian H,Madadi N,Nikbin B

更新日期：2006-10-01 00:00:00

abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...

journal_title：International journal of immunogenetics

authors： Suslova TA,Burmistrova AL,Chernova MS,Khromova EB,Lupar EI,Timofeeva SV,Devald IV,Vavilov MN,Darke C

更新日期：2012-10-01 00:00:00

abstract：:Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). ICAM-1 expression is associated with increasing Breslow thickness of vertical growth-phase tumours and, in patients with stage 1 disease, may be associated with disease free...

journal_title：International journal of immunogenetics

authors： Howell WM,Rose-Zerilli MJ,Theaker JM,Bateman AC

更新日期：2005-12-01 00:00:00

abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...

journal_title：International journal of immunogenetics

authors： Figueiredo TC,de Oliveira JR

更新日期：2012-06-01 00:00:00

abstract：:A novel MICB allele, MICB*030, has been identified in a healthy Chinese individual of Mongol ethnicity residing in northern China by polymerase chain reaction sequence-based typing (PCR-SBT) and confirmed by cloning and sequencing. MICB*030 was linked to HLA-B*35. Aligned with MICB*005:02, MICB*030 has a nonsynonymous...

journal_title：International journal of immunogenetics

authors： Wang WY,Wang F,Tian W

更新日期：2015-08-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...

journal_title：International journal of immunogenetics

authors： Köhler KF,Petzl-Erler ML

更新日期：2006-04-01 00:00:00

abstract：:Catalase (CAT) is an antioxidant enzyme and plays a significant role in the protection against oxidative stress by reducing hydrogen peroxide. The CAT cDNA of Eriocheir sinensis (EsCAT) was cloned via RACE technique. The complete sequence of EsCAT cDNA consisted of a 5' untranslated regions (UTR) of 224 bp, a 3' UTR o...

journal_title：International journal of immunogenetics

authors： Wang M,Wang L,Zhou Z,Gao Y,Wang L,Shi X,Gai Y,Mu C,Song L

更新日期：2013-06-01 00:00:00

abstract：:Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 ...

journal_title：International journal of immunogenetics

authors： Vural P,Küskü-Kiraz Z,Doğru-Abbasoğlu S,Cil E,Karadağ B,Uysal M

更新日期：2010-08-01 00:00:00

abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...

journal_title：International journal of immunogenetics

authors： Mamoulakis D,Bitsori M,Galanakis E,Vazgiourakis V,Panierakis C,Goulielmos GN

更新日期：2009-06-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is the most important TLR among the pattern recognition receptors which recognizes lipopolysaccharide of gram-negative bacteria. They identify a highly conserved structure of microbes called pathogen-associated molecular patterns and activate immune and inflammatory responses that have been...

journal_title：International journal of immunogenetics

authors： Sinha S,Singh J,Jindal SK,Birbian N,Singla N

更新日期：2014-12-01 00:00:00

abstract：:HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoi...

journal_title：International journal of immunogenetics

authors： Foster L,Tate D,Poulton K

更新日期：2013-08-01 00:00:00

abstract：:Earlier studies suggested that a variable number tandem repeat (VNTR) polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene might be associated with some chronic inflammatory diseases, autoimmune diseases and solid tumours. To study the distribution of this polymorphism in China, 1352 samples...

journal_title：International journal of immunogenetics

authors： Jiang J,Zhang X,Sun D,Jin Y,Bai J,Chen F,Fu S

更新日期：2010-04-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...

journal_title：International journal of immunogenetics

authors： da Silva Cezar RD,da Silva Castanha PM,Matos Freire N,Mola C,Feliciano do Carmo R,Tenório Cordeiro M,Baptista P,Silva Vasconcelos LR,Moura P,da Silva Teixeira VG

更新日期：2020-08-01 00:00:00

abstract：:According to the IMGT/HLA Database, the DNA sequence of A*11:53 is identical to A*11:02:01 in exons 2, 3, 4 and 5 except at codon 276. A*11:53 was reported as a rare variant of A*11, while A*11:02:01 was understood to be the second most frequently observed variant of A*11 after A*11:01:01 in Taiwanese. We sequenced HL...

journal_title：International journal of immunogenetics

authors： Yang KL,Chu CC,Marsh SG,Lin PY

更新日期：2012-12-01 00:00:00

abstract：:Single nucleotide polymorphisms within the promoter or other regulatory sequences of cytokine genes were evaluated and compared between an Iranian population and populations of different ethnic/geographical background. In 40 healthy Iranian subjects, cytokine typing was performed by polymerase chain reaction-sequence-...

journal_title：International journal of immunogenetics

authors： Bagheri M,Abdi-Rad I,Omrani D,Khalkhali HR

更新日期：2006-06-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four s...

journal_title：International journal of immunogenetics

authors： Lobo-Alves SC,de Oliveira LA,Petzl-Erler ML

更新日期：2019-06-01 00:00:00

abstract：:The Luminex xMAP system has become an important tool for HLA antibody screening and identification in sera of transplant patients. Recently, the Luminex single antigen bead assay was shown to be prone to an artefact, the so called prozone phenomenon: Sera with high titer HLA antibodies gave negative results when teste...

journal_title：International journal of immunogenetics

authors： Weinstock C,Schnaidt M

更新日期：2013-06-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNFalpha) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in relation to genetic variants and TNFalpha protein production. Therefore, we assessed the functionality of TNFalpha genetic...

journal_title：International journal of immunogenetics

authors： O'Dwyer MJ,Mankan AK,Ryan AW,Lawless MW,Stordeur P,Kelleher D,McManus R,Ryan T

更新日期：2008-08-01 00:00:00

abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

journal_title：International journal of immunogenetics

authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

更新日期：2012-06-01 00:00:00

abstract：:Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context...

journal_title：International journal of immunogenetics

authors： Mangieri LFL,Sena MM,Cezar-Dos-Santos F,Trugilo KP,Okuyama NCM,Pereira ÉR,Maria GCQ,Watanabe MAE,de Oliveira KB

更新日期：2019-10-01 00:00:00

abstract：:Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of...

journal_title：International journal of immunogenetics

authors： Yao Q,Fischer KP,Tyrrell DL,Gutfreund KS

更新日期：2015-04-01 00:00:00

abstract：:Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-association studies that KIR receptors can play beneficial roles in viral ...

journal_title：International journal of immunogenetics

authors： Gardiner CM

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-...

journal_title：International journal of immunogenetics

authors： Albanidou-Farmaki E,Deligiannidis A,Markopoulos AK,Katsares V,Farmakis K,Parapanissiou E

更新日期：2008-12-01 00:00:00

abstract：:Heme oxygenase isoenzyme HO-1 has been linked to several cytoprotective functions with a potentially beneficial role in transplantation. In the present study, the effect of genetic variation in HO-1 on renal allograft outcome was investigated. Six hundred and eighty patients subject to renal transplantation in a singl...

journal_title：International journal of immunogenetics

authors： Turpeinen H,Kyllönen LE,Parkkinen J,Laine J,Salmela KT,Partanen J

更新日期：2007-08-01 00:00:00

abstract：:We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT a...

journal_title：International journal of immunogenetics

authors： Yang KL,Lee SK,Yang SY,Kao RH,Lin CL,Lin PY

更新日期：2013-04-01 00:00:00

abstract：:Type I interferons (IFN) are important mediators of the host defence against viruses through binding to the cell surface receptors, among which the binding to type I IFN receptor 2 (IFNAR2) is the very first step initiating a complex signal transduction cascade. By using RT-PCR and 5' RACE approaches, we obtained porc...

journal_title：International journal of immunogenetics

authors： Xing F,Li Y,Liang S,Liu D,Jiang C,Zhang Y,Kang L,Jiang Y

更新日期：2011-08-01 00:00:00

abstract：:Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...

journal_title：International journal of immunogenetics

authors： Harishankar M,Selvaraj P,Rajeswari DN,Anand SP,Narayanan PR

更新日期：2007-10-01 00:00:00

abstract：:It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. However, s...

journal_title：International journal of immunogenetics

authors： Howell WM

更新日期：2014-02-01 00:00:00

abstract：:In the present study, we addressed the question of how often HLA-DRB1-matched donors can be found by further typing of AB-matched donors and whether Cw preselection can be helpful. Sixty-eight patients and 174 donors were enrolled in the study. In all donors, confirmatory DNA Cw typing was performed to check reliabili...

journal_title：International journal of immunogenetics

authors： Nowak J,Mika-Witkowska R,Zajko M,Łopacz P

更新日期：2005-10-01 00:00:00