Abstract：
:We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Hulin-Curtis SL,Bidwell JL,Perry MJdoi
10.1111/iji.12015subject
Has Abstractpub_date
2013-08-01 00:00:00pages
280-3issue
4eissn
1744-3121issn
1744-313Xjournal_volume
40pub_type
杂志文章abstract：:Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2005.00494.x
更新日期：2005-04-01 00:00:00
abstract：:Genome-wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases. In addition, emerging evid...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01084.x
更新日期：2012-06-01 00:00:00
abstract：:The African buffalo (Syncerus caffer) has been implicated as the reservoir of several bovine infectious agents. However, there is insufficient information on the protective immune responses in the African buffalo, particularly in infected animals. In this study, we analysed Th1 cytokines IL-2 and IFN-γ, and Th2 cytoki...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01062.x
更新日期：2012-04-01 00:00:00
abstract：:The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in the susceptibility and/or the disease profile of rheumatoid arthritis (RA) in Egyptian patients. TNF-α-308 G/promoter polymorphism detection by amplification refractory mutation system (ARMS)...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01028.x
更新日期：2011-10-01 00:00:00
abstract：:Coenzyme Q (CoQ or ubiquinone) is a lipid-soluble component of virtually all types of cell membranes and has been shown to play multiple metabolic functions. Several clinical diseases including encephalomyopathy, cerebellar ataxia and isolated myopathy were shown to be associated with CoQ deficiency. However, the role...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01012.x
更新日期：2011-08-01 00:00:00
abstract：:In the present study, DNA typing for human leucocyte antigen (HLA)-DPB1, -DRB1, and -DQB1 was performed using polymerase chain reaction-sequence-based-typing (PCR-SBT) method on 94 randomly selected, healthy, unrelated individuals from the Ewenki ethnic population in Inner Mongolia Autonomous Region of China. A total ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2007.00718.x
更新日期：2007-12-01 00:00:00
abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12477
更新日期：2020-08-01 00:00:00
abstract：:Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12175
更新日期：2015-04-01 00:00:00
abstract：:Haematopoietic stem cell transplantation (HSCT), using unrelated donors (UD), is now a common modality of treatment for individuals with a variety of different diseases. HLA matching has been shown to have a significant impact on patient outcome. This study includes 423 unrelated UK patient/donor pairs. The patients a...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2008.00793.x
更新日期：2008-08-01 00:00:00
abstract：:Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four s...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12423
更新日期：2019-06-01 00:00:00
abstract：:Immunological studies have supported the idea that innate immunity is critical for the control of Mycobacterium tuberculosis (Mtb) infection in humans. Despite the overwhelming evidence showing the critical role of Toll-like receptors (TLRs) in the in vitro recognition of Mtb, the in vivo significance of individual TL...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01077.x
更新日期：2012-06-01 00:00:00
abstract：:In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to com...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12313
更新日期：2017-06-01 00:00:00
abstract：:The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selecti...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
doi：10.1111/j.1744-313X.2008.00756.x
更新日期：2008-04-01 00:00:00
abstract：:The single nucleotide polymorphism (SNP) G949T in the mannose-binding lectin ( MBL ) 1 gene has been associated with low MBL-A concentration in serum and detected at different frequencies in various European pig populations. However, the origin of this SNP is not known. Part of the MBL1 gene was sequenced in 12 wild b...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01132.x
更新日期：2013-04-01 00:00:00
abstract：:Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2010.00915.x
更新日期：2010-08-01 00:00:00
abstract：:Tumour necrosis factor-alpha (TNFalpha) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in relation to genetic variants and TNFalpha protein production. Therefore, we assessed the functionality of TNFalpha genetic...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2008.00773.x
更新日期：2008-08-01 00:00:00
abstract：:Catalase (CAT) is an antioxidant enzyme and plays a significant role in the protection against oxidative stress by reducing hydrogen peroxide. The CAT cDNA of Eriocheir sinensis (EsCAT) was cloned via RACE technique. The complete sequence of EsCAT cDNA consisted of a 5' untranslated regions (UTR) of 224 bp, a 3' UTR o...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12019
更新日期：2013-06-01 00:00:00
abstract：:We have used molecular methods to determine the frequencies of human leukocyte antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from North India using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes as there is no comprehensive report showing molecu...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2007.00677.x
更新日期：2007-06-01 00:00:00
abstract：:HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoi...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12004
更新日期：2013-08-01 00:00:00
abstract：:The distributions of HLA allele and haplotype are variable in different ethnic populations and the data for some populations have been published. However, the data on HLA-C and HLA-DQB1 loci and the haplotype of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci at a high-resolution level are limited in Zhejiang Han popu...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12411
更新日期：2019-02-01 00:00:00
abstract：:We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2006.00641.x
更新日期：2007-02-01 00:00:00
abstract：:HLA donor-specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA develo...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12519
更新日期：2021-02-01 00:00:00
abstract：:Type 1 diabetes mellitus (T1DM) is a heterogeneous autoimmune disease, and both environmental and genetic factors play a role in its pathogenesis. Interleukin (IL)-18 is a potent pro-inflammatory cytokine capable of inducing interferon-gamma production that is associated with the development of T1DM. The gene for IL-1...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2007.00665.x
更新日期：2007-04-01 00:00:00
abstract：:Currently, there is a lack of information on polymorphism of human leucocyte antigen-F (HLA-F) gene in ethnically diverse human populations. In this study, HLA-F allelic typing was performed for 690 individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese pop...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12047
更新日期：2013-10-01 00:00:00
abstract：:The present study aimed to analyse the frequencies of human leukocyte antigen HLA-ABCDQB1 and HLA-DRB1 alleles and haplotypes in a subset of 3,732 Han population from Hubei of China. All samples were typed in the HLA-ABCDQB1 and HLA-DRB1 loci using the sequence-based typing method; subsequently, the HLA polymorphisms ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12516
更新日期：2021-02-01 00:00:00
abstract：:Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2006.00585.x
更新日期：2006-04-01 00:00:00
abstract：:Many genes related to innate and adaptive immunity reside within the major histocompatibility complex (MHC) and have been associated with a multitude of complex, immune-related disorders. Despite years of genetic study, this region has seen few causative determinants discovered for immune-mediated diseases. Reported a...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
doi：10.1111/iji.12236
更新日期：2015-12-01 00:00:00
abstract：:This piece was originally requested as a white paper from the Scientific and Clinical Affairs Committee of the American Society for Histocompatibility and Immunogenetics (ASHI), of which the author was then Chairman. Upon review by the ASHI Board of Directors and the Editors of their journal, it was considered too con...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
doi：10.1111/j.1744-313X.2008.00768.x
更新日期：2008-08-01 00:00:00
abstract：:FcγRIIB contains a unique immunoreceptor tyrosine-based inhibition motif (ITIM) and functions as a negative feedback regulator of leucocyte activation and antibody production. We have previously reported FcγRIIB-nt645+25A/G gene polymorphism to be associated with prevalence and severity of periodontitis, FcγRIIB expre...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01124.x
更新日期：2012-12-01 00:00:00
abstract：:The past decade has witnessed hundreds of reports declaring or not being able to replicable genetic association with systemic lupus erythematosus (SLE) susceptibility. BANK1 is a gene that encodes a B-cell-specific scaffold protein and its activation can affect B-cell-receptor-induced calcium mobilization from intrace...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,meta分析
doi：10.1111/j.1744-313X.2010.00990.x
更新日期：2011-04-01 00:00:00
