Abstract：
:This piece was originally requested as a white paper from the Scientific and Clinical Affairs Committee of the American Society for Histocompatibility and Immunogenetics (ASHI), of which the author was then Chairman. Upon review by the ASHI Board of Directors and the Editors of their journal, it was considered too controversial for publication. It is intended to be provocative and controversial; it is not intended as a review of the literature. Though written with a decided 'American point of view', it is of importance that the issues facing US transplantation and laboratory testing efforts are shared to varying degrees by the international community, and who, unlike some of their American cousins, may be able to tolerate a spirited discussion. Sadly, we sometimes forget that dissent from dogma can be fun!
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Eckels DDdoi
10.1111/j.1744-313X.2008.00768.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
265-74issue
4-5eissn
1744-3121issn
1744-313Xpii
EJI768journal_volume
35pub_type
杂志文章,评审abstract：:Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-association studies that KIR receptors can play beneficial roles in viral ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
doi：10.1111/j.1744-313X.2007.00739.x
更新日期：2008-02-01 00:00:00
abstract：:The African buffalo (Syncerus caffer) has been implicated as the reservoir of several bovine infectious agents. However, there is insufficient information on the protective immune responses in the African buffalo, particularly in infected animals. In this study, we analysed Th1 cytokines IL-2 and IFN-γ, and Th2 cytoki...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01062.x
更新日期：2012-04-01 00:00:00
abstract：:Immunological inflammatory reaction is one of the key links in the occurrence and development of post-traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN-γ and bone remodelling cells. However, potential association of IFN-γ gene polymorphism with susceptibility ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12462
更新日期：2020-04-01 00:00:00
abstract：:The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms wer...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2010.00937.x
更新日期：2010-10-01 00:00:00
abstract：:A new allelic variant in MICB*005 lineage, MICB*005:09, has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR-sequence-based typing (Sanger sequencing) and confirmed by cloning and sequencing. Aligned with MICB*005:03, this new allelic variant shows a synonymous...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12410
更新日期：2019-02-01 00:00:00
abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01074.x
更新日期：2012-06-01 00:00:00
abstract：:The past decade has witnessed hundreds of reports declaring or not being able to replicable genetic association with systemic lupus erythematosus (SLE) susceptibility. BANK1 is a gene that encodes a B-cell-specific scaffold protein and its activation can affect B-cell-receptor-induced calcium mobilization from intrace...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,meta分析
doi：10.1111/j.1744-313X.2010.00990.x
更新日期：2011-04-01 00:00:00
abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01117.x
更新日期：2012-10-01 00:00:00
abstract：:FcγRIIB contains a unique immunoreceptor tyrosine-based inhibition motif (ITIM) and functions as a negative feedback regulator of leucocyte activation and antibody production. We have previously reported FcγRIIB-nt645+25A/G gene polymorphism to be associated with prevalence and severity of periodontitis, FcγRIIB expre...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01124.x
更新日期：2012-12-01 00:00:00
abstract：:Leprosy is one of the most neglected infectious tropical diseases of the skin and the nerves caused by the intracellular pathogen Mycobacterium leprae. The inducible NOS isoform encoded by NOS2A plays a vital role in host defence against bacterial infections. The functional promoter polymorphisms in NOS2A are associat...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12108
更新日期：2014-06-01 00:00:00
abstract：:This study assessed the phenotypic and allelic profiles of ABO and Rhesus D blood group system among first time blood donors at the National Centre of Blood Supply of Antananarivo. We collected through this retrospective study all data registered during 7 years of practice (from 2003 to 2009). Age and sex were analyse...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01120.x
更新日期：2012-12-01 00:00:00
abstract：:Haematopoietic stem cell transplantation (HSCT) remains the only cure for most haematological malignancies, however, the mortality rate remains high. Complications after HSCT include relapse, graft versus host disease (GvHD), graft rejection and infection. Over the last few years several groups, have demonstrated that...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12380
更新日期：2018-07-25 00:00:00
abstract：:Killer cells immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed mainly by natural killer (NK) cells and few subsets of T lymphocytes. KIRs regulate NK cells' activity through interactions with specific HLA class I molecules and other yet unknown ligands presented on targ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2007.00737.x
更新日期：2008-02-01 00:00:00
abstract：:The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selecti...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
doi：10.1111/j.1744-313X.2008.00756.x
更新日期：2008-04-01 00:00:00
abstract：:Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01107.x
更新日期：2012-10-01 00:00:00
abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2009.00839.x
更新日期：2009-06-01 00:00:00
abstract：:Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2006.00585.x
更新日期：2006-04-01 00:00:00
abstract：:We report here a novel human leukocyte antigen (HLA) allele, DRB1*1449, in the Han-Chinese population. The nature of the new allele was confirmed by the sequencing-based typing (SBT) method. Genomic DNA and six subclones containing DNA fragment of DRB1 exon 2 were sequenced in both forward and reverse directions. The ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2005.00557.x
更新日期：2006-02-01 00:00:00
abstract：:Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmona...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2007.00703.x
更新日期：2007-10-01 00:00:00
abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...
journal_title：International journal of immunogenetics
pub_type： 临床试验,杂志文章
doi：10.1111/iji.12351
更新日期：2018-02-01 00:00:00
abstract：:Mannose binding lectin (MBL) is an important innate immune system pattern recognition molecule. The MBL gene polymorphisms are reported to play a crucial role in outcome of hepatitis B virus (HBV) infection. In this study, we ascertained the association of MBL genotypes with HBV outcome in a South Indian population. T...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2010.00908.x
更新日期：2010-06-01 00:00:00
abstract：:The genetic and immunophenotypic characteristics of a 3-year-old patient with Blau syndrome (BS), an early onset sarcoidosis caused by mutations in NOD2, were investigated. Molecular analysis of NOD2 gene was achieved by PCR and direct nucleotide sequencing. Immunophenotyping included cytometric analysis of memory-eff...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.00998.x
更新日期：2011-06-01 00:00:00
abstract：:Type I interferons (IFN) are important mediators of the host defence against viruses through binding to the cell surface receptors, among which the binding to type I IFN receptor 2 (IFNAR2) is the very first step initiating a complex signal transduction cascade. By using RT-PCR and 5' RACE approaches, we obtained porc...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01018.x
更新日期：2011-08-01 00:00:00
abstract：:Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2005.00494.x
更新日期：2005-04-01 00:00:00
abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01076.x
更新日期：2012-06-01 00:00:00
abstract：:The single nucleotide polymorphism (SNP) G949T in the mannose-binding lectin ( MBL ) 1 gene has been associated with low MBL-A concentration in serum and detected at different frequencies in various European pig populations. However, the origin of this SNP is not known. Part of the MBL1 gene was sequenced in 12 wild b...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2012.01132.x
更新日期：2013-04-01 00:00:00
abstract：:Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12175
更新日期：2015-04-01 00:00:00
abstract：:The present study aimed to analyse the frequencies of human leukocyte antigen HLA-ABCDQB1 and HLA-DRB1 alleles and haplotypes in a subset of 3,732 Han population from Hubei of China. All samples were typed in the HLA-ABCDQB1 and HLA-DRB1 loci using the sequence-based typing method; subsequently, the HLA polymorphisms ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/iji.12516
更新日期：2021-02-01 00:00:00
abstract：:The Luminex xMAP system has become an important tool for HLA antibody screening and identification in sera of transplant patients. Recently, the Luminex single antigen bead assay was shown to be prone to an artefact, the so called prozone phenomenon: Sera with high titer HLA antibodies gave negative results when teste...
journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
doi：10.1111/j.1744-313X.2012.01147.x
更新日期：2013-06-01 00:00:00
abstract：:The T-cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to be associated with susceptibility to rheumatoid arthritis (RA). In this study, we investigated the association of four single-nucleotide polymorphisms (SNPs) of the TIM-3 gene with RA susceptibility in Chinese Hui and Han groups. Using restriction ...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2011.01046.x
更新日期：2011-12-01 00:00:00
