当前位置： SCI文献检索 > International Journal of Immunogenetics期刊下所有文献 > CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions.

CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions.

Abstract：

:Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context, we highlight the CC chemokine receptor 5 (CCR5) which is involved in leucocytes chemotaxis to sites of inflammation, controlling the immune response. The CCR5 rs333 genotyping of 164 HPV infected women and 185 non-infected women was performed using polymerase chain reaction (PCR). HPV infection was more frequent among women under 34 years old (p < 0.001), single (p = 0.001), that received 1 minimum wage or less (p = 0.002), tobacco smokers (p = 0.007), who had the first sexual intercourse before 17 years old (p = 0.038) and that had 4 or more sexual partners during lifetime (p = 0.001). No significant difference regarding genotypes and alleles distribution according to HPV infection was observed. CCR5/CCR5 genotype was observed in 94.1% of HPV non-infected women and in 89% of infected ones, CCR5/Δ32 in 5.9% of HPV infected and in 10.4% of non-infected women, and Δ32/Δ32 was observed in only one (0.6%) infected patient. CCR5 genotypes were also not associated with cervical lesions development among HPV infected women (p = 0.167). Since CCR5 may control the antitumour immune response and cervical lesions and the studied rs333 polymorphism is not very frequent, other studies are necessary, in order to establish CCR5 role on HPV infection and squamous intraepithelial lesions development.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Mangieri LFL,Sena MM,Cezar-Dos-Santos F,Trugilo KP,Okuyama NCM,Pereira ÉR,Maria GCQ,Watanabe MAE,de Oliveira KB

doi

10.1111/iji.12444

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

331-338

issue

5

eissn

1744-3121

issn

1744-313X

journal_volume

46

pub_type

杂志文章

相关文献

International Journal of Immunogenetics文献大全
  • Dominant, non-MHC genetic control of food allergy in an adjuvant-free mouse model.

    abstract：:Food allergy is a potentially fatal immune-mediated disorder with incompletely understood mechanisms. We studied the genetic control of food allergy using major histocompatibility complex-identical mice (H2(s)) and an adjuvant-free method of sensitization. Whereas, transdermal exposure to hazelnut - a model allergenic...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00860.x

    authors： Parvataneni S,Birmingham NP,Gonipeta B,Gangur V

    更新日期：2009-10-01 00:00:00

  • HLA gene and haplotype frequencies in Russians, Bashkirs and Tatars, living in the Chelyabinsk Region (Russian South Urals).

    abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01117.x

    authors： Suslova TA,Burmistrova AL,Chernova MS,Khromova EB,Lupar EI,Timofeeva SV,Devald IV,Vavilov MN,Darke C

    更新日期：2012-10-01 00:00:00

  • Th-1 cytokines gene polymorphism in human brucellosis.

    abstract：:Brucellosis is a worldwide zoonosis. Infection with Brucella species results in the activation of cell-mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possibl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00626.x

    authors： Davoudi S,Amirzargar AA,Hajiabdolbaghi M,Rasoolinejad M,Soodbakhsh A,Jafari S,Piri H,Maleknejad P,Bagherian H,Madadi N,Nikbin B

    更新日期：2006-10-01 00:00:00

  • MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan.

    abstract：:The single nucleotide polymorphism (SNP) G949T in the mannose-binding lectin ( MBL ) 1 gene has been associated with low MBL-A concentration in serum and detected at different frequencies in various European pig populations. However, the origin of this SNP is not known. Part of the MBL1 gene was sequenced in 12 wild b...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01132.x

    authors： Bergman IM,Sandholm K,Ekdahl KN,Okumura N,Uenishi H,Guldbrandtsen B,Essler SE,Knoll A,Heegaard PM,Edfors I,Juul-Madsen HR

    更新日期：2013-04-01 00:00:00

  • Intron 4 polymorphism of the endothelial nitric oxide synthase eNOS gene and early microangiopathy in type 1 diabetes.

    abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00839.x

    authors： Mamoulakis D,Bitsori M,Galanakis E,Vazgiourakis V,Panierakis C,Goulielmos GN

    更新日期：2009-06-01 00:00:00

  • Heme oxygenase 1 gene polymorphisms and outcome of renal transplantation.

    abstract：:Heme oxygenase isoenzyme HO-1 has been linked to several cytoprotective functions with a potentially beneficial role in transplantation. In the present study, the effect of genetic variation in HO-1 on renal allograft outcome was investigated. Six hundred and eighty patients subject to renal transplantation in a singl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00688.x

    authors： Turpeinen H,Kyllönen LE,Parkkinen J,Laine J,Salmela KT,Partanen J

    更新日期：2007-08-01 00:00:00

  • Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non-coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem).

    abstract：:Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four s...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12423

    authors： Lobo-Alves SC,de Oliveira LA,Petzl-Erler ML

    更新日期：2019-06-01 00:00:00

  • Association of tumour necrosis factor-alpha -308 G/A promoter polymorphism with susceptibility and disease profile of rheumatoid arthritis.

    abstract：:The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in the susceptibility and/or the disease profile of rheumatoid arthritis (RA) in Egyptian patients. TNF-α-308 G/promoter polymorphism detection by amplification refractory mutation system (ARMS)...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01028.x

    authors： Mosaad YM,Abdelsalam A,El-Bassiony SR

    更新日期：2011-10-01 00:00:00

  • The distributions of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 allele and haplotype at high-resolution level in Zhejiang Han population of China.

    abstract：:The distributions of HLA allele and haplotype are variable in different ethnic populations and the data for some populations have been published. However, the data on HLA-C and HLA-DQB1 loci and the haplotype of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci at a high-resolution level are limited in Zhejiang Han popu...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12411

    authors： Chen N,Wang W,Wang F,Dong L,Zhao S,Zhang W,He J,Huang H,Zhu F

    更新日期：2019-02-01 00:00:00

  • Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.

    abstract：:Genes involved in regulation of the nuclear factor - kappa B (NF-κB) pathway are suggested to play a role in the pathogenesis of acute myeloid leukaemia (AML). The present study aimed to assess the association between the NF-κB1, TRAF3 and TLRs genes single nucleotide polymorphisms (SNPs) and disease susceptibility as...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12255

    authors： Rybka J,Gębura K,Wróbel T,Wysoczańska B,Stefanko E,Kuliczkowski K,Bogunia-Kubik K

    更新日期：2016-04-01 00:00:00

  • Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes.

    abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...

    journal_title：International journal of immunogenetics

    pub_type： 临床试验,杂志文章

    doi：10.1111/iji.12351

    authors： Bonatti F,Adorni A,Percesepe A,Martorana D

    更新日期：2018-02-01 00:00:00

  • TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients.

    abstract：:The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms wer...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00937.x

    authors： Silva MM,Simões RT,Castelli EC,Mendes-Junior CT,Deghaide NH,Tsuda LC,Machado AA,Donadi EA,Fernandes AP

    更新日期：2010-10-01 00:00:00

  • Genetic association of interleukin-2, interleukin-4, interleukin-6, transforming growth factor-β, tumour necrosis factor-α and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients.

    abstract：:Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12192

    authors： Seyhun Y,Ciftci HS,Kekik C,Karadeniz MS,Tefik T,Nane I,Turkmen A,Oguz FS,Aydin F

    更新日期：2015-06-01 00:00:00

  • Genetic variants of the inflammatory C-reactive protein and schizophrenia in Armenian population: a pilot study.

    abstract：:C-reactive protein (CRP) is an inflammation marker implicated in the pathogenesis of schizophrenia. To investigate association of the CRP rs1417938, rs1800947, rs1205 variants with susceptibility to schizophrenia 208 unrelated Armenians (103 patients and 105 healthy controls) were genotyped. In this pilot study, none ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00942.x

    authors： Zakharyan R,Chavushyan A,Khoyetsyan A,Stahelova A,Arakelyan A,Boyajyan A,Mrazek F,Petrek M

    更新日期：2010-10-01 00:00:00

  • ICAM-1 polymorphisms and development of cutaneous malignant melanoma.

    abstract：:Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). ICAM-1 expression is associated with increasing Breslow thickness of vertical growth-phase tumours and, in patients with stage 1 disease, may be associated with disease free...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00539.x

    authors： Howell WM,Rose-Zerilli MJ,Theaker JM,Bateman AC

    更新日期：2005-12-01 00:00:00

  • IFN-γ +874T/A polymorphism increases susceptibility to post-traumatic osteomyelitis.

    abstract：:Immunological inflammatory reaction is one of the key links in the occurrence and development of post-traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN-γ and bone remodelling cells. However, potential association of IFN-γ gene polymorphism with susceptibility ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12462

    authors： Zhao XQ,Jiang N,Hu YJ,Yu B

    更新日期：2020-04-01 00:00:00

  • Association between CCL2 haplotypes and knee osteoarthritis.

    abstract：:We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in t...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12015

    authors： Hulin-Curtis SL,Bidwell JL,Perry MJ

    更新日期：2013-08-01 00:00:00

  • Role of TLR4 C>1196T (Thr399Ile) and TLR4 A>896G (Asp299Gly) polymorphisms in a North Indian population with asthma: a case-control study.

    abstract：:Toll-like receptor 4 (TLR4) is the most important TLR among the pattern recognition receptors which recognizes lipopolysaccharide of gram-negative bacteria. They identify a highly conserved structure of microbes called pathogen-associated molecular patterns and activate immune and inflammatory responses that have been...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12115

    authors： Sinha S,Singh J,Jindal SK,Birbian N,Singla N

    更新日期：2014-12-01 00:00:00

  • TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients.

    abstract：:The Toll-like receptors (TLRs) are related to innate immunity. TLR9, a member of TLRs, is expressed in immune cell-rich tissues and mediates cellular response. We investigated the association between TLR9 polymorphisms and kidney allograft outcomes. To investigate whether TLR9 polymorphisms are associated with acute r...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,多中心研究

    doi：10.1111/iji.12069

    authors： Kim TH,Jeong KH,Kim SK,Lee SH,Ihm CG,Lee TW,Moon JY,Yoon YC,Chung JH,Park SJ,Kang SW,Kim YH

    更新日期：2013-12-01 00:00:00

  • HLA-B*15 subtypes distribution in Han population in Beijing, China, as compared with those of other populations.

    abstract：:To identify HLA-B*15 subtypes distribution in Han population in Beijing, People's Republic of China, 826 unrelated healthy individuals were typed using the polymerase chain reaction-sequence-based typing method. Within the 246 HLA-B*15 positive individuals, 29 HLA-B*15 alleles were identified, the most predominant of ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00910.x

    authors： Yang G,Deng YJ,Qin H,Zhu BF,Chen F,Shen CM,Sun ZM,Chen LP,Wu J,Mu HF,Lucas R

    更新日期：2010-06-01 00:00:00

  • Distribution of KIR genes in the Czech population.

    abstract：:Killer cells immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed mainly by natural killer (NK) cells and few subsets of T lymphocytes. KIRs regulate NK cells' activity through interactions with specific HLA class I molecules and other yet unknown ligands presented on targ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00737.x

    authors： Pavlova Y,Kolesar L,Striz I,Jabor A,Slavcev A

    更新日期：2008-02-01 00:00:00

  • Cytokine typing: SNP allele frequencies in the Iranian population.

    abstract：:Single nucleotide polymorphisms within the promoter or other regulatory sequences of cytokine genes were evaluated and compared between an Iranian population and populations of different ethnic/geographical background. In 40 healthy Iranian subjects, cytokine typing was performed by polymerase chain reaction-sequence-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,收录出版

    doi：10.1111/j.1744-313X.2006.00595.x

    authors： Bagheri M,Abdi-Rad I,Omrani D,Khalkhali HR

    更新日期：2006-06-01 00:00:00

  • Genetic polymorphisms of tumour necrosis factor alpha (TNF-α) promoter gene and response to TNF-α inhibitors in Spanish patients with inflammatory bowel disease.

    abstract：:Tumour necrosis factor alpha (TNF-α) has an important role in inflammatory response. Alterations in the regulation of TNF-α have been implicated in a variety of inflammatory disorders, including Inflammatory bowel disease (IBD). Indeed, a common treatment for IBD is the use of TNF-α inhibitors. Polymorphisms in the TN...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12059

    authors： López-Hernández R,Valdés M,Campillo JA,Martínez-Garcia P,Salama H,Salgado G,Boix F,Moya-Quiles MR,Minguela A,Sánchez-Torres A,Miras M,Garcia A,Carballo F,Álvarez-López MR,Muro M

    更新日期：2014-02-01 00:00:00

  • Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater-Accra region of Ghana, towards effective blood bank inventory.

    abstract：:Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12412

    authors： Doku GN,Agbozo WK,Annor RA,Kisseh GD,Owusu MA

    更新日期：2019-04-01 00:00:00

  • Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population.

    abstract：:Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00714.x

    authors： Harishankar M,Selvaraj P,Rajeswari DN,Anand SP,Narayanan PR

    更新日期：2007-10-01 00:00:00

  • Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer).

    abstract：:The African buffalo (Syncerus caffer) has been implicated as the reservoir of several bovine infectious agents. However, there is insufficient information on the protective immune responses in the African buffalo, particularly in infected animals. In this study, we analysed Th1 cytokines IL-2 and IFN-γ, and Th2 cytoki...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01062.x

    authors： Suzuki S,Konnai S,Okagawa T,Githaka NW,Kariuki E,Gakuya F,Kanduma E,Shirai T,Ikebuchi R,Ikenaka Y,Ishizuka M,Murata S,Ohashi K

    更新日期：2012-04-01 00:00:00

  • Association of mannose-binding lectin polymorphisms and HBV outcome in a South Indian population.

    abstract：:Mannose binding lectin (MBL) is an important innate immune system pattern recognition molecule. The MBL gene polymorphisms are reported to play a crucial role in outcome of hepatitis B virus (HBV) infection. In this study, we ascertained the association of MBL genotypes with HBV outcome in a South Indian population. T...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00908.x

    authors： Fletcher GJ,Gnanamony M,Samuel P,Ismail AM,Kannangai R,Daniel D,Eapen CE,Abraham P

    更新日期：2010-06-01 00:00:00

  • Molecular diversity of HLA-A, -B and -C alleles in a North Indian population as determined by PCR-SSOP.

    abstract：:We have used molecular methods to determine the frequencies of human leukocyte antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from North India using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes as there is no comprehensive report showing molecu...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00677.x

    authors： Rani R,Marcos C,Lazaro AM,Zhang Y,Stastny P

    更新日期：2007-06-01 00:00:00

  • Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis.

    abstract：:Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmona...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00703.x

    authors： Rajeswari DN,Selvaraj P,Raghavan S,Jawahar MS,Narayanan PR

    更新日期：2007-10-01 00:00:00

  • Frequencies of MICA alleles in patients from southern Brazil with multibacillary and paucibacillary leprosy.

    abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01074.x

    authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

    更新日期：2012-06-01 00:00:00