MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan.

abstract：:Mannose-binding lectin (MBL) is a key molecule of the innate immune system and a competent to bind carbohydrates of a variety of microorganisms, resulting in complement activation and opsonophagocytosis against various pathogens. However, there is no systemic investigation on the MBL's role in innate immune responses ...

journal_title：International journal of immunogenetics

authors： Sheng A,Lan J,Wu H,Lu J,Wang Y,Chu Q,Jia Z,Song M,Liu L,Wang W

更新日期：2010-12-01 00:00:00

abstract：:In the present study, DNA typing for human leucocyte antigen (HLA)-DPB1, -DRB1, and -DQB1 was performed using polymerase chain reaction-sequence-based-typing (PCR-SBT) method on 94 randomly selected, healthy, unrelated individuals from the Ewenki ethnic population in Inner Mongolia Autonomous Region of China. A total ...

journal_title：International journal of immunogenetics

authors： Su X,Bi L,Hai R,Qimuge S,Ying M,Bahring S,Gong M

更新日期：2007-12-01 00:00:00

abstract：:FcγRIIB contains a unique immunoreceptor tyrosine-based inhibition motif (ITIM) and functions as a negative feedback regulator of leucocyte activation and antibody production. We have previously reported FcγRIIB-nt645+25A/G gene polymorphism to be associated with prevalence and severity of periodontitis, FcγRIIB expre...

journal_title：International journal of immunogenetics

authors： Wang Y,Sugita N,Kikuchi A,Iwanaga R,Hirano E,Shimada Y,Sasahara J,Tanaka K,Yoshie H

更新日期：2012-12-01 00:00:00

abstract：:Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...

journal_title：International journal of immunogenetics

authors： Harishankar M,Selvaraj P,Rajeswari DN,Anand SP,Narayanan PR

更新日期：2007-10-01 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder caused by an interaction between genes and environmental triggers. Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have sh...

journal_title：International journal of immunogenetics

authors： Djurovic J,Stojkovic O,Ozdemir O,Silan F,Akurut C,Todorovic J,Savic K,Stamenkovic G

更新日期：2015-06-01 00:00:00

abstract：:Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 ...

journal_title：International journal of immunogenetics

authors： Vural P,Küskü-Kiraz Z,Doğru-Abbasoğlu S,Cil E,Karadağ B,Uysal M

更新日期：2010-08-01 00:00:00

abstract：:Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...

journal_title：International journal of immunogenetics

authors： Bown MJ,Weston S,Horsburgh T,Nicholson ML,Bell PR,Sayers RD

更新日期：2005-04-01 00:00:00

abstract：:Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...

journal_title：International journal of immunogenetics

authors： Yavari M,Brinkley G,Klapstein KD,Hartwig WC,Rao R,Hermel E

更新日期：2012-10-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF-α) has an important role in inflammatory response. Alterations in the regulation of TNF-α have been implicated in a variety of inflammatory disorders, including Inflammatory bowel disease (IBD). Indeed, a common treatment for IBD is the use of TNF-α inhibitors. Polymorphisms in the TN...

journal_title：International journal of immunogenetics

authors： López-Hernández R,Valdés M,Campillo JA,Martínez-Garcia P,Salama H,Salgado G,Boix F,Moya-Quiles MR,Minguela A,Sánchez-Torres A,Miras M,Garcia A,Carballo F,Álvarez-López MR,Muro M

更新日期：2014-02-01 00:00:00

abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...

journal_title：International journal of immunogenetics

authors： Mamoulakis D,Bitsori M,Galanakis E,Vazgiourakis V,Panierakis C,Goulielmos GN

更新日期：2009-06-01 00:00:00

abstract：:Single nucleotide polymorphisms within the promoter or other regulatory sequences of cytokine genes were evaluated and compared between an Iranian population and populations of different ethnic/geographical background. In 40 healthy Iranian subjects, cytokine typing was performed by polymerase chain reaction-sequence-...

journal_title：International journal of immunogenetics

authors： Bagheri M,Abdi-Rad I,Omrani D,Khalkhali HR

更新日期：2006-06-01 00:00:00

abstract：:The T-cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to be associated with susceptibility to rheumatoid arthritis (RA). In this study, we investigated the association of four single-nucleotide polymorphisms (SNPs) of the TIM-3 gene with RA susceptibility in Chinese Hui and Han groups. Using restriction ...

journal_title：International journal of immunogenetics

authors： Xu J,Yang Y,Liu X,Wang Y

更新日期：2011-12-01 00:00:00

abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...

journal_title：International journal of immunogenetics

authors： Bonatti F,Adorni A,Percesepe A,Martorana D

更新日期：2018-02-01 00:00:00

abstract：:Catalase (CAT) is an antioxidant enzyme and plays a significant role in the protection against oxidative stress by reducing hydrogen peroxide. The CAT cDNA of Eriocheir sinensis (EsCAT) was cloned via RACE technique. The complete sequence of EsCAT cDNA consisted of a 5' untranslated regions (UTR) of 224 bp, a 3' UTR o...

journal_title：International journal of immunogenetics

authors： Wang M,Wang L,Zhou Z,Gao Y,Wang L,Shi X,Gai Y,Mu C,Song L

更新日期：2013-06-01 00:00:00

abstract：:Immunological inflammatory reaction is one of the key links in the occurrence and development of post-traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN-γ and bone remodelling cells. However, potential association of IFN-γ gene polymorphism with susceptibility ...

journal_title：International journal of immunogenetics

authors： Zhao XQ,Jiang N,Hu YJ,Yu B

更新日期：2020-04-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) remains the only cure for most haematological malignancies, however, the mortality rate remains high. Complications after HSCT include relapse, graft versus host disease (GvHD), graft rejection and infection. Over the last few years several groups, have demonstrated that...

journal_title：International journal of immunogenetics

authors： Norden J,Pearce KF,Irving JAE,Collin MP,Wang XN,Wolff D,Kolb HJ,Socie G,Kuzmina Z,Greinix H,Holler E,Rocha V,Gluckman E,Hromadnikova I,Dickinson AM

更新日期：2018-07-25 00:00:00

abstract：:In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to com...

journal_title：International journal of immunogenetics

authors： Wang H,Guo J,Jiang J,Wu W,Chang X,Zhou H,Li Z,Zhao J

更新日期：2017-06-01 00:00:00

abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...

journal_title：International journal of immunogenetics

authors： Suslova TA,Burmistrova AL,Chernova MS,Khromova EB,Lupar EI,Timofeeva SV,Devald IV,Vavilov MN,Darke C

更新日期：2012-10-01 00:00:00

abstract：:We have used molecular methods to determine the frequencies of human leukocyte antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from North India using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes as there is no comprehensive report showing molecu...

journal_title：International journal of immunogenetics

authors： Rani R,Marcos C,Lazaro AM,Zhang Y,Stastny P

更新日期：2007-06-01 00:00:00

abstract：:It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. However, s...

journal_title：International journal of immunogenetics

authors： Howell WM

更新日期：2014-02-01 00:00:00

abstract：:The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selecti...

journal_title：International journal of immunogenetics

authors： Martinez-Borra J,Khakoo SI

更新日期：2008-04-01 00:00:00

abstract：:The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms wer...

journal_title：International journal of immunogenetics

authors： Silva MM,Simões RT,Castelli EC,Mendes-Junior CT,Deghaide NH,Tsuda LC,Machado AA,Donadi EA,Fernandes AP

更新日期：2010-10-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) is the most important TLR among the pattern recognition receptors which recognizes lipopolysaccharide of gram-negative bacteria. They identify a highly conserved structure of microbes called pathogen-associated molecular patterns and activate immune and inflammatory responses that have been...

journal_title：International journal of immunogenetics

authors： Sinha S,Singh J,Jindal SK,Birbian N,Singla N

更新日期：2014-12-01 00:00:00

abstract：:Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They ...

journal_title：International journal of immunogenetics

authors： Seyhun Y,Ciftci HS,Kekik C,Karadeniz MS,Tefik T,Nane I,Turkmen A,Oguz FS,Aydin F

更新日期：2015-06-01 00:00:00

abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

journal_title：International journal of immunogenetics

authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

更新日期：2012-06-01 00:00:00

abstract：:We report here a novel human leukocyte antigen (HLA) allele, DRB1*1449, in the Han-Chinese population. The nature of the new allele was confirmed by the sequencing-based typing (SBT) method. Genomic DNA and six subclones containing DNA fragment of DRB1 exon 2 were sequenced in both forward and reverse directions. The ...

journal_title：International journal of immunogenetics

authors： Miao KR,Xue M,Zhou XY,Xu R,Fei XM,Pan QQ,Zhang JW,Zhao X,Fan S,KuKuruga D,Xu AL,Wang CY

更新日期：2006-02-01 00:00:00

abstract：:HLA donor-specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA develo...

journal_title：International journal of immunogenetics

authors： Tafulo S,Malheiro J,Santos S,Dias L,Almeida M,Martins S,Pedroso S,Mendes C,Lobato L,Castro-Henriques A

更新日期：2021-02-01 00:00:00

abstract：:C-reactive protein (CRP) is an inflammation marker implicated in the pathogenesis of schizophrenia. To investigate association of the CRP rs1417938, rs1800947, rs1205 variants with susceptibility to schizophrenia 208 unrelated Armenians (103 patients and 105 healthy controls) were genotyped. In this pilot study, none ...

journal_title：International journal of immunogenetics

authors： Zakharyan R,Chavushyan A,Khoyetsyan A,Stahelova A,Arakelyan A,Boyajyan A,Mrazek F,Petrek M

更新日期：2010-10-01 00:00:00

abstract：:The distributions of HLA allele and haplotype are variable in different ethnic populations and the data for some populations have been published. However, the data on HLA-C and HLA-DQB1 loci and the haplotype of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci at a high-resolution level are limited in Zhejiang Han popu...

journal_title：International journal of immunogenetics

authors： Chen N,Wang W,Wang F,Dong L,Zhao S,Zhang W,He J,Huang H,Zhu F

更新日期：2019-02-01 00:00:00

abstract：:A novel MICB allele, MICB*030, has been identified in a healthy Chinese individual of Mongol ethnicity residing in northern China by polymerase chain reaction sequence-based typing (PCR-SBT) and confirmed by cloning and sequencing. MICB*030 was linked to HLA-B*35. Aligned with MICB*005:02, MICB*030 has a nonsynonymous...

journal_title：International journal of immunogenetics

authors： Wang WY,Wang F,Tian W

更新日期：2015-08-01 00:00:00