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Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population.

Abstract：

:Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotype and haplotype frequencies did not differ significantly between normal healthy subjects and patients. The results suggest that the IL-18 gene promoter polymorphisms are not associated with susceptibility or resistance to pulmonary tuberculosis in south Indian population of Dravidian descent.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Harishankar M,Selvaraj P,Rajeswari DN,Anand SP,Narayanan PR

doi

10.1111/j.1744-313X.2007.00714.x

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

317-20

issue

5

eissn

1744-3121

issn

1744-313X

pii

EJI714

journal_volume

34

pub_type

杂志文章

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