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Characterization of a novel DRB1*14 allele (DRB1*1449) in the Han-Chinese population.

Abstract：

:We report here a novel human leukocyte antigen (HLA) allele, DRB1*1449, in the Han-Chinese population. The nature of the new allele was confirmed by the sequencing-based typing (SBT) method. Genomic DNA and six subclones containing DNA fragment of DRB1 exon 2 were sequenced in both forward and reverse directions. The exon 2 nucleotide sequence of DRB1*1449 is closely related to DRB1*1432 allele based on sequence homology. It has four nucleotide (nt) substitutions at positions 71, 196, 244 and 245 in exon 2, which lead to changes of amino acid sequences. The serological assignment of DRB1*1449 is DR14 based on the serological HLA typing result. This novel allele might be a result of recombination between DRB1*1402 and DRB1*140101 like alleles, which are very common among Chinese population.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Miao KR,Xue M,Zhou XY,Xu R,Fei XM,Pan QQ,Zhang JW,Zhao X,Fan S,KuKuruga D,Xu AL,Wang CY

doi

10.1111/j.1744-313X.2005.00557.x

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

33-5

issue

1

eissn

1744-3121

issn

1744-313X

pii

EJI557

journal_volume

33

pub_type

杂志文章

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