Abstract:
:Heme oxygenase isoenzyme HO-1 has been linked to several cytoprotective functions with a potentially beneficial role in transplantation. In the present study, the effect of genetic variation in HO-1 on renal allograft outcome was investigated. Six hundred and eighty patients subject to renal transplantation in a single transplant unit and their cadaveric kidney donors were included in this study. Four single-nucleotide polymorphisms and one microsatellite marker in the HO-1 gene region were analysed. Some statistically nominally significant associations were observed in preliminary analyses between polymorphisms studied and clinical outcomes, but after correction for multiple comparisons none remained significant. Our data suggest that the HO-1 gene polymorphisms studied have no significant role on outcome of kidney transplantation in the Finnish population.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Turpeinen H,Kyllönen LE,Parkkinen J,Laine J,Salmela KT,Partanen Jdoi
10.1111/j.1744-313X.2007.00688.xsubject
Has Abstractpub_date
2007-08-01 00:00:00pages
253-7issue
4eissn
1744-3121issn
1744-313Xpii
EJI688journal_volume
34pub_type
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journal_title:International journal of immunogenetics
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abstract::Sunlight/ultraviolet (UV) irradiation has been recognized as an important risk factor for developing systemic lupus erythematosus (SLE). However, the interpretation of genetic variations involved in UV-light sensitivity is largely unknown. Recent studies indicated that two genetic variations of ERCC2/XPD gene (rs17997...
journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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abstract::The genetic and immunophenotypic characteristics of a 3-year-old patient with Blau syndrome (BS), an early onset sarcoidosis caused by mutations in NOD2, were investigated. Molecular analysis of NOD2 gene was achieved by PCR and direct nucleotide sequencing. Immunophenotyping included cytometric analysis of memory-eff...
journal_title:International journal of immunogenetics
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abstract::Type I interferons (IFN) are important mediators of the host defence against viruses through binding to the cell surface receptors, among which the binding to type I IFN receptor 2 (IFNAR2) is the very first step initiating a complex signal transduction cascade. By using RT-PCR and 5' RACE approaches, we obtained porc...
journal_title:International journal of immunogenetics
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abstract::Natural killer (NK) cells have killer cell immunoglobulin-like receptors (KIR) that recognize and interact with HLA class I antigen. The KIRs are a multigene family and its members are often highly polymorphic. Evidence is emerging from disease-association studies that KIR receptors can play beneficial roles in viral ...
journal_title:International journal of immunogenetics
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abstract::Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
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abstract::C-reactive protein (CRP) is an inflammation marker implicated in the pathogenesis of schizophrenia. To investigate association of the CRP rs1417938, rs1800947, rs1205 variants with susceptibility to schizophrenia 208 unrelated Armenians (103 patients and 105 healthy controls) were genotyped. In this pilot study, none ...
journal_title:International journal of immunogenetics
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abstract::Illumina first introduced their TruSight human leucocyte antigen (HLA) next-generation sequencing (NGS) typing kit in 2015 and subsequently followed up with a new version in 2016. Here we report on our experience comparing the two versions of the Illumina HLA NGS kits. ...
journal_title:International journal of immunogenetics
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abstract::Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
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abstract::Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2006.00585.x
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journal_title:International journal of immunogenetics
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doi:10.1111/j.1744-313X.2012.01120.x
更新日期:2012-12-01 00:00:00
abstract::The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...
journal_title:International journal of immunogenetics
pub_type: 临床试验,杂志文章
doi:10.1111/iji.12351
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abstract::We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine ...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2006.00641.x
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journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2012.01084.x
更新日期:2012-06-01 00:00:00
abstract::A novel MICB allele, MICB*030, has been identified in a healthy Chinese individual of Mongol ethnicity residing in northern China by polymerase chain reaction sequence-based typing (PCR-SBT) and confirmed by cloning and sequencing. MICB*030 was linked to HLA-B*35. Aligned with MICB*005:02, MICB*030 has a nonsynonymous...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12207
更新日期:2015-08-01 00:00:00
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journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2005.00557.x
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
pub_type: 杂志文章
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abstract::To identify HLA-B*15 subtypes distribution in Han population in Beijing, People's Republic of China, 826 unrelated healthy individuals were typed using the polymerase chain reaction-sequence-based typing method. Within the 246 HLA-B*15 positive individuals, 29 HLA-B*15 alleles were identified, the most predominant of ...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2010.00910.x
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abstract::Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...
journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
pub_type: 杂志文章
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journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2007.00714.x
更新日期:2007-10-01 00:00:00
abstract::Autoimmune diabetes [type 1 diabetes mellitus (T1DM), latent autoimmune diabetes in adults (LADA) and part of malnutrition-related diabetes] has been shown to have genetic predisposition. Studies in IDDM 5 have lead to the discovery of a novel polymorphism 163 A-->G, of SUMO4 (small ubiquitin-related modifier) gene, a...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
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