Abstract：
:This study assessed the phenotypic and allelic profiles of ABO and Rhesus D blood group system among first time blood donors at the National Centre of Blood Supply of Antananarivo. We collected through this retrospective study all data registered during 7 years of practice (from 2003 to 2009). Age and sex were analysed with the result of ABO and RhD screening. They were tested both with Beth Vincent and Simonin tests which were performed in a plate, by using commercial monoclonal antibody (Diaclone(®) et Eryclone(®)), and home-made red cells tests. The Rh D was performed with the same commercial kits. The frequencies of alleles were calculated by using Bernstein method. Data about 45,857 donors were obtained. A male predominance (80.46%) was found and most of our donors were aged <40 (74.92%). 98.90% of the donors were Rh D positive. Phenotypic distribution of each ABO antigen was, respectively, 22.61, 29.66, 6.13 and 41.60% for A, B, AB and O antigen. Allelic frequencies of A, B and O were 0.1559, 0.1987 and 0.6454. These results confirmed the fact that Madagascan population had admixed ethnic origin.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Randriamanantany ZA,Rajaonatahina DH,Razafimanantsoa FE,Rasamindrakotroka MT,Andriamahenina R,Rasoarilalamanarivo FB,Hanitriniala SP,Herisoa FR,Rasamindrakotroka A,Rakoto Alson OAdoi
10.1111/j.1744-313X.2012.01120.xsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
477-9issue
6eissn
1744-3121issn
1744-313Xjournal_volume
39pub_type
杂志文章abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...
journal_title：International journal of immunogenetics
pub_type： 杂志文章
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abstract：:Autoimmune diabetes [type 1 diabetes mellitus (T1DM), latent autoimmune diabetes in adults (LADA) and part of malnutrition-related diabetes] has been shown to have genetic predisposition. Studies in IDDM 5 have lead to the discovery of a novel polymorphism 163 A-->G, of SUMO4 (small ubiquitin-related modifier) gene, a...
journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
pub_type： 杂志文章
doi：10.1111/j.1744-313X.2005.00557.x
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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journal_title：International journal of immunogenetics
pub_type： 杂志文章
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journal_title：International journal of immunogenetics
pub_type： 杂志文章,评审
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journal_title：International journal of immunogenetics
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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journal_title：International journal of immunogenetics
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journal_title：International journal of immunogenetics
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