Abstract:
:Immunological inflammatory reaction is one of the key links in the occurrence and development of post-traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN-γ and bone remodelling cells. However, potential association of IFN-γ gene polymorphism with susceptibility to post-traumatic osteomyelitis remains unclear. This study aimed to investigate the potential link between IFN-γ +874T/A polymorphism and risk of developing post-traumatic osteomyelitis. A total of 189 patients with post-traumatic osteomyelitis and 200 healthy controls were enrolled for genotyping using the SNaPshot genotyping method. Statistically significant associations were found between the gene polymorphism and the risk of post-traumatic osteomyelitis by dominant model (AA + AT vs. TT, OR = 1.820, p = .017) and heterozygous model (AT vs. TT, OR = 1.781, p = .029). Moreover, the frequency of mutant allele A was significantly higher in the patients than that in the healthy controls (15.07% vs. 9.25%, OR = 1.742, p = .013). IFN-γ +874T/A polymorphism may contribute to the increased susceptibility to post-traumatic osteomyelitis.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Zhao XQ,Jiang N,Hu YJ,Yu Bdoi
10.1111/iji.12462subject
Has Abstractpub_date
2020-04-01 00:00:00pages
163-168issue
2eissn
1744-3121issn
1744-313Xjournal_volume
47pub_type
杂志文章abstract::A new allelic variant in MICB*005 lineage, MICB*005:09, has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR-sequence-based typing (Sanger sequencing) and confirmed by cloning and sequencing. Aligned with MICB*005:03, this new allelic variant shows a synonymous...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12410
更新日期:2019-02-01 00:00:00
abstract::Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They ...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12192
更新日期:2015-06-01 00:00:00
abstract::In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to com...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12313
更新日期:2017-06-01 00:00:00
abstract::Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2005.00494.x
更新日期:2005-04-01 00:00:00
abstract::Sunlight/ultraviolet (UV) irradiation has been recognized as an important risk factor for developing systemic lupus erythematosus (SLE). However, the interpretation of genetic variations involved in UV-light sensitivity is largely unknown. Recent studies indicated that two genetic variations of ERCC2/XPD gene (rs17997...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2008.00817.x
更新日期:2009-02-01 00:00:00
abstract::The objective was to analyze the possible involvement of tumour necrosis factor-alpha (TNF-α) -308 G/A promoter polymorphism in the susceptibility and/or the disease profile of rheumatoid arthritis (RA) in Egyptian patients. TNF-α-308 G/promoter polymorphism detection by amplification refractory mutation system (ARMS)...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2011.01028.x
更新日期:2011-10-01 00:00:00
abstract::Toll-like receptor 4 (TLR4) is the most important TLR among the pattern recognition receptors which recognizes lipopolysaccharide of gram-negative bacteria. They identify a highly conserved structure of microbes called pathogen-associated molecular patterns and activate immune and inflammatory responses that have been...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12115
更新日期:2014-12-01 00:00:00
abstract::Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12412
更新日期:2019-04-01 00:00:00
abstract::Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 ...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2010.00915.x
更新日期:2010-08-01 00:00:00
abstract::Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12444
更新日期:2019-10-01 00:00:00
abstract::Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presen...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12185
更新日期:2015-06-01 00:00:00
abstract::Haematopoietic stem cell transplantation (HSCT) remains the only cure for most haematological malignancies, however, the mortality rate remains high. Complications after HSCT include relapse, graft versus host disease (GvHD), graft rejection and infection. Over the last few years several groups, have demonstrated that...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12380
更新日期:2018-07-25 00:00:00
abstract::Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmona...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2007.00703.x
更新日期:2007-10-01 00:00:00
abstract::HLA donor-specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA develo...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12519
更新日期:2021-02-01 00:00:00
abstract::We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2011.01076.x
更新日期:2012-06-01 00:00:00
abstract::We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT a...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2012.01143.x
更新日期:2013-04-01 00:00:00
abstract::Mannose-binding lectin (MBL) is a protein able to bind to carbohydrate patterns on pathogen membranes; upon MBL binding, its' associated serine protease MBL-associated serine protease type 2 (MASP2) is autoactivated, promoting the activation of complement via the lectin pathway. For both MBL2 and MASP2 genes, the freq...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2011.01052.x
更新日期:2012-02-01 00:00:00
abstract::Immunological studies have supported the idea that innate immunity is critical for the control of Mycobacterium tuberculosis (Mtb) infection in humans. Despite the overwhelming evidence showing the critical role of Toll-like receptors (TLRs) in the in vitro recognition of Mtb, the in vivo significance of individual TL...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2011.01077.x
更新日期:2012-06-01 00:00:00
abstract::Polymorphic Alu insertions (POALINs) are found throughout the human genome and have been used in various studies to infer geographic origin of human populations. The main aim of this study was to determine the allele and haplotype frequencies of five POALINs, AluHF, AluHG, AluHJ, AluTF and AluMICB, within the major hi...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12426
更新日期:2019-08-01 00:00:00
abstract::We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in t...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12015
更新日期:2013-08-01 00:00:00
abstract::Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2006.00585.x
更新日期:2006-04-01 00:00:00
abstract::HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoi...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12004
更新日期:2013-08-01 00:00:00
abstract::We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine ...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2006.00641.x
更新日期:2007-02-01 00:00:00
abstract::We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2012.01117.x
更新日期:2012-10-01 00:00:00
abstract::The single nucleotide polymorphism (SNP) G949T in the mannose-binding lectin ( MBL ) 1 gene has been associated with low MBL-A concentration in serum and detected at different frequencies in various European pig populations. However, the origin of this SNP is not known. Part of the MBL1 gene was sequenced in 12 wild b...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2012.01132.x
更新日期:2013-04-01 00:00:00
abstract::A novel MICB allele, MICB*030, has been identified in a healthy Chinese individual of Mongol ethnicity residing in northern China by polymerase chain reaction sequence-based typing (PCR-SBT) and confirmed by cloning and sequencing. MICB*030 was linked to HLA-B*35. Aligned with MICB*005:02, MICB*030 has a nonsynonymous...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/iji.12207
更新日期:2015-08-01 00:00:00
abstract::Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2012.01107.x
更新日期:2012-10-01 00:00:00
abstract::Tumour necrosis factor-alpha (TNFalpha) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in relation to genetic variants and TNFalpha protein production. Therefore, we assessed the functionality of TNFalpha genetic...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2008.00773.x
更新日期:2008-08-01 00:00:00
abstract::The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2008.00801.x
更新日期:2008-12-01 00:00:00
abstract::Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
doi:10.1111/j.1744-313X.2007.00714.x
更新日期:2007-10-01 00:00:00