Abstract:
:Haematopoietic stem cell transplantation (HSCT), using unrelated donors (UD), is now a common modality of treatment for individuals with a variety of different diseases. HLA matching has been shown to have a significant impact on patient outcome. This study includes 423 unrelated UK patient/donor pairs. The patients and donors were typed at high resolution for HLA-A, -B, -C, -DRB1, -DQB1, -DPB1. The degree and type of HLA mismatch was found to be a significant factor affecting outcome. The matching status for DPB1, both at an allele and epitope level, significantly affected transplant complications. The findings of this study have made it possible to offer advice concerning the choice of the most appropriate unrelated donor to select in order to achieve the best patient outcomes.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Shaw BEdoi
10.1111/j.1744-313X.2008.00793.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
367-74issue
4-5eissn
1744-3121issn
1744-313Xpii
EJI793journal_volume
35pub_type
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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doi:10.1111/j.1744-313X.2005.00539.x
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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abstract::Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...
journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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journal_title:International journal of immunogenetics
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abstract::The Luminex xMAP system has become an important tool for HLA antibody screening and identification in sera of transplant patients. Recently, the Luminex single antigen bead assay was shown to be prone to an artefact, the so called prozone phenomenon: Sera with high titer HLA antibodies gave negative results when teste...
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abstract::Currently, there is a lack of information on polymorphism of human leucocyte antigen-F (HLA-F) gene in ethnically diverse human populations. In this study, HLA-F allelic typing was performed for 690 individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese pop...
journal_title:International journal of immunogenetics
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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