Abstract:
:Coenzyme Q (CoQ or ubiquinone) is a lipid-soluble component of virtually all types of cell membranes and has been shown to play multiple metabolic functions. Several clinical diseases including encephalomyopathy, cerebellar ataxia and isolated myopathy were shown to be associated with CoQ deficiency. However, the role of CoQ in immunity has not been defined. In the present study, we showed that flies defective in CoQ biosynthetic gene coq2 were more susceptible to bacterial and fungal infections, while were more resistant to viruses. We found that Drosophila contained both CoQ9 and CoQ10, and food supplement of CoQ10 could partially rescue the impaired immune functions of coq2 mutants. Surprisingly, wild-type flies fed CoQ10 became more susceptible to viral infection, which suggested that extra caution should be taken when using CoQ10 as a food supplement. We further showed that CoQ was essential for normal induction of anti-microbial peptides and amplification of viruses. Our work determined CoQ content in Drosophila and described its function in immunity for the first time.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Cheng W,Song C,Anjum KM,Chen M,Li D,Zhou H,Wang W,Chen Jdoi
10.1111/j.1744-313X.2011.01012.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
331-7issue
4eissn
1744-3121issn
1744-313Xjournal_volume
38pub_type
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