Abstract:
:We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT at codon 58). We hypothesize DRB1*09:01:08 was probably derived from DRB1*09:01:02 via a nucleotide point mutation event. The plausible HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08 was deduced as A*02:07-B*46:01-DRB1*09:01:08.
journal_name
Int J Immunogenetjournal_title
International journal of immunogeneticsauthors
Yang KL,Lee SK,Yang SY,Kao RH,Lin CL,Lin PYdoi
10.1111/j.1744-313X.2012.01143.xsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
149-50issue
2eissn
1744-3121issn
1744-313Xjournal_volume
40pub_type
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