当前位置： SCI文献检索 > International Journal of Immunogenetics期刊下所有文献 > Study on the polymorphisms of HLA-ABCDQB1DRB1 alleles and haplotypes in Hubei Han population of China.

Study on the polymorphisms of HLA-ABCDQB1DRB1 alleles and haplotypes in Hubei Han population of China.

Abstract：

:The present study aimed to analyse the frequencies of human leukocyte antigen HLA-ABCDQB1 and HLA-DRB1 alleles and haplotypes in a subset of 3,732 Han population from Hubei of China. All samples were typed in the HLA-ABCDQB1 and HLA-DRB1 loci using the sequence-based typing method; subsequently, the HLA polymorphisms were analysed. A total of 47 HLA-A, 89 HLA-B, 43 HLA-C, 49 HLA-DRB1 and 24 HLA-DQB1 alleles were identified in the Hubei Han population. The top three most frequent alleles in the HLA-ABCDQB1 and HLA-DRB1 were A*11:01 (0.2617), A*24:02 (0.1590), A*02:07 (0.1281); B*46:01 (0.1502), B*40:01 (0.1409) and B*58:01 (0.0616); C*01:02 (0.2023), C*07:02 (0.1691) and C*03:04 (0.1175); and DQB1*03:01 (0.2000), DQB1*03:03 (0.1900), DQB1*06:01 (0.1187); DRB1*09:01 (0.1790), DRB1*15:01 (0.1062) and DRB1*12:02 (0.0841), respectively. Meanwhile, the three most frequent two-loci haplotypes were A*02:07-C*01:02 (0.0929), B*46:01-C*01:02 (0.1366) and DQB1*03:03-DRB1*09:01 (0.1766). The three most frequent three-loci haplotypes were A*02:07-B*46:01-C*01:02 (0.0883), B*46:01-DQB1*03:03-DRB1*09:01 (0.0808) and C*01:02-DQB1*03:03-DRB1*09:01 (0.0837). The three most frequent four-loci haplotypes were A*02:07-B*46:01-C*01:02-DQB1*03:03 (0.0494), B*46:01-DRB1*09:01-C*01:02-DQB1*03:03 (0.0729) and A*02:07-B*46:01-DQB1*03:03-DRB1*09:01 (0.0501). The most frequent five-loci haplotype was A*02:07-B*46:01-C*01:02-DQB1*03:03-DRB1*09:01 (0.0487). Heat maps and multiple correspondence analysis based on the frequencies of HLA specificity indicated that the Hubei Han population might be described into Southern Chinese populations. Our results lay a certain foundation for future population studies, disease association studies and donor recruitment strategies.

journal_name

Int J Immunogenet

journal_title

International journal of immunogenetics

authors

Zou J,Shen G,Qiang W,Zhu YY,Li WX

doi

10.1111/iji.12516

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

8-15

issue

1

eissn

1744-3121

issn

1744-313X

journal_volume

48

pub_type

杂志文章

相关文献

International Journal of Immunogenetics文献大全
  • Discovery of the novel HLA-DRB1*09:01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08.

    abstract：:We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT a...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01143.x

    authors： Yang KL,Lee SK,Yang SY,Kao RH,Lin CL,Lin PY

    更新日期：2013-04-01 00:00:00

  • HLA genotyping using the Illumina HLA TruSight next-generation sequencing kits: A comparison.

    abstract：:Illumina first introduced their TruSight human leucocyte antigen (HLA) next-generation sequencing (NGS) typing kit in 2015 and subsequently followed up with a new version in 2016. Here we report on our experience comparing the two versions of the Illumina HLA NGS kits. ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12322

    authors： Profaizer T,Lázár-Molnár E,Pole A,Delgado JC,Kumánovics A

    更新日期：2017-08-01 00:00:00

  • HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?

    abstract：:The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2008.00801.x

    authors： Albanidou-Farmaki E,Deligiannidis A,Markopoulos AK,Katsares V,Farmakis K,Parapanissiou E

    更新日期：2008-12-01 00:00:00

  • Solid phase testing in the HLA laboratory: implications for organ allocation.

    abstract：:This piece was originally requested as a white paper from the Scientific and Clinical Affairs Committee of the American Society for Histocompatibility and Immunogenetics (ASHI), of which the author was then Chairman. Upon review by the ASHI Board of Directors and the Editors of their journal, it was considered too con...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2008.00768.x

    authors： Eckels DD

    更新日期：2008-08-01 00:00:00

  • Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.

    abstract：:Genes involved in regulation of the nuclear factor - kappa B (NF-κB) pathway are suggested to play a role in the pathogenesis of acute myeloid leukaemia (AML). The present study aimed to assess the association between the NF-κB1, TRAF3 and TLRs genes single nucleotide polymorphisms (SNPs) and disease susceptibility as...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12255

    authors： Rybka J,Gębura K,Wróbel T,Wysoczańska B,Stefanko E,Kuliczkowski K,Bogunia-Kubik K

    更新日期：2016-04-01 00:00:00

  • Frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del in healthy Polish individuals.

    abstract：:Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presen...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12185

    authors： Lewandowska M,Garczyńska P,Jędrychowska-Dańska K,Kopczyńska P,Masłowska A,Witas H

    更新日期：2015-06-01 00:00:00

  • CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions.

    abstract：:Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12444

    authors： Mangieri LFL,Sena MM,Cezar-Dos-Santos F,Trugilo KP,Okuyama NCM,Pereira ÉR,Maria GCQ,Watanabe MAE,de Oliveira KB

    更新日期：2019-10-01 00:00:00

  • TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients.

    abstract：:The Toll-like receptors (TLRs) are related to innate immunity. TLR9, a member of TLRs, is expressed in immune cell-rich tissues and mediates cellular response. We investigated the association between TLR9 polymorphisms and kidney allograft outcomes. To investigate whether TLR9 polymorphisms are associated with acute r...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,多中心研究

    doi：10.1111/iji.12069

    authors： Kim TH,Jeong KH,Kim SK,Lee SH,Ihm CG,Lee TW,Moon JY,Yoon YC,Chung JH,Park SJ,Kang SW,Kim YH

    更新日期：2013-12-01 00:00:00

  • Identification of a novel MICB allele, MICB*030, by cloning and sequencing.

    abstract：:A novel MICB allele, MICB*030, has been identified in a healthy Chinese individual of Mongol ethnicity residing in northern China by polymerase chain reaction sequence-based typing (PCR-SBT) and confirmed by cloning and sequencing. MICB*030 was linked to HLA-B*35. Aligned with MICB*005:02, MICB*030 has a nonsynonymous...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12207

    authors： Wang WY,Wang F,Tian W

    更新日期：2015-08-01 00:00:00

  • Genetic variants of the inflammatory C-reactive protein and schizophrenia in Armenian population: a pilot study.

    abstract：:C-reactive protein (CRP) is an inflammation marker implicated in the pathogenesis of schizophrenia. To investigate association of the CRP rs1417938, rs1800947, rs1205 variants with susceptibility to schizophrenia 208 unrelated Armenians (103 patients and 105 healthy controls) were genotyped. In this pilot study, none ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00942.x

    authors： Zakharyan R,Chavushyan A,Khoyetsyan A,Stahelova A,Arakelyan A,Boyajyan A,Mrazek F,Petrek M

    更新日期：2010-10-01 00:00:00

  • Association of mannose-binding lectin polymorphisms and HBV outcome in a South Indian population.

    abstract：:Mannose binding lectin (MBL) is an important innate immune system pattern recognition molecule. The MBL gene polymorphisms are reported to play a crucial role in outcome of hepatitis B virus (HBV) infection. In this study, we ascertained the association of MBL genotypes with HBV outcome in a South Indian population. T...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00908.x

    authors： Fletcher GJ,Gnanamony M,Samuel P,Ismail AM,Kannangai R,Daniel D,Eapen CE,Abraham P

    更新日期：2010-06-01 00:00:00

  • HLA class II eplet mismatch load improves prediction of dnDSA development after living donor kidney transplantation.

    abstract：:HLA donor-specific antibodies developed de novo after transplant remain a major cause of chronic allograft dysfunction. Our study main purpose was to determine whether HLA MM, assessed traditionally and by HLA total and AbVer eplet mismatch load (EptMM and EpvMM) assessed with HLAMatchMaker, had impact on dnDSA develo...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12519

    authors： Tafulo S,Malheiro J,Santos S,Dias L,Almeida M,Martins S,Pedroso S,Mendes C,Lobato L,Castro-Henriques A

    更新日期：2021-02-01 00:00:00

  • Vascular endothelial growth factor +405 G/C,-460 T/C and -2578 A/C polymorphisms are not associated with insulin resistance in polycystic ovary syndrome.

    abstract：:Insulin resistance (IR) and pancreatic beta-cell dysfunction are usual comorbidities in polycystic ovary syndrome (PCOS). Vascular endothelial growth factor (VEGF) is known to play an important role in the pathogenesis of PCOS. This study examined firstly the possible association of common +405 G/C,-460 T/C and -2578 ...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2010.00915.x

    authors： Vural P,Küskü-Kiraz Z,Doğru-Abbasoğlu S,Cil E,Karadağ B,Uysal M

    更新日期：2010-08-01 00:00:00

  • A chromosomal event resulting in possession and expression of multiple HLA-B and Cw genes in a renal patient.

    abstract：:Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric s...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00610.x

    authors： Poole K,Montague B,Roberts R,Stoves J,Bendukidze N,Clark B

    更新日期：2006-08-01 00:00:00

  • Cytokine typing: SNP allele frequencies in the Iranian population.

    abstract：:Single nucleotide polymorphisms within the promoter or other regulatory sequences of cytokine genes were evaluated and compared between an Iranian population and populations of different ethnic/geographical background. In 40 healthy Iranian subjects, cytokine typing was performed by polymerase chain reaction-sequence-...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,收录出版

    doi：10.1111/j.1744-313X.2006.00595.x

    authors： Bagheri M,Abdi-Rad I,Omrani D,Khalkhali HR

    更新日期：2006-06-01 00:00:00

  • Presence of the functional CASPASE-12 allele in Indian subpopulations.

    abstract：:Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2012.01107.x

    authors： Yavari M,Brinkley G,Klapstein KD,Hartwig WC,Rao R,Hermel E

    更新日期：2012-10-01 00:00:00

  • The complement-mediated prozone effect in the Luminex single-antigen bead assay and its impact on HLA antibody determination in patient sera.

    abstract：:The Luminex xMAP system has become an important tool for HLA antibody screening and identification in sera of transplant patients. Recently, the Luminex single antigen bead assay was shown to be prone to an artefact, the so called prozone phenomenon: Sera with high titer HLA antibodies gave negative results when teste...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1744-313X.2012.01147.x

    authors： Weinstock C,Schnaidt M

    更新日期：2013-06-01 00:00:00

  • Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis.

    abstract：:Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA-DRB1 alleles on peripheral blood perforin-positive CD4, CD8, CD16 and CD 56 cells was studied by flow cytometry. HLA-DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmona...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2007.00703.x

    authors： Rajeswari DN,Selvaraj P,Raghavan S,Jawahar MS,Narayanan PR

    更新日期：2007-10-01 00:00:00

  • MHC class I polymorphic Alu insertion (POALIN) allele and haplotype frequencies in the Arabs of the United Arab Emirates and other world populations.

    abstract：:Polymorphic Alu insertions (POALINs) are found throughout the human genome and have been used in various studies to infer geographic origin of human populations. The main aim of this study was to determine the allele and haplotype frequencies of five POALINs, AluHF, AluHG, AluHJ, AluTF and AluMICB, within the major hi...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12426

    authors： Kulski JK,Mawart A,Marie K,Tay GK,AlSafar HS

    更新日期：2019-08-01 00:00:00

  • Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes.

    abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...

    journal_title：International journal of immunogenetics

    pub_type： 临床试验,杂志文章

    doi：10.1111/iji.12351

    authors： Bonatti F,Adorni A,Percesepe A,Martorana D

    更新日期：2018-02-01 00:00:00

  • Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations.

    abstract：:Earlier studies suggested that a variable number tandem repeat (VNTR) polymorphism in intron 2 of the interleukin-1 receptor antagonist (IL-1RA) gene might be associated with some chronic inflammatory diseases, autoimmune diseases and solid tumours. To study the distribution of this polymorphism in China, 1352 samples...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2009.00891.x

    authors： Jiang J,Zhang X,Sun D,Jin Y,Bai J,Chen F,Fu S

    更新日期：2010-04-01 00:00:00

  • cDNA cloning, genomic structure and mRNA expression pattern of porcine type I interferons receptor 2 gene.

    abstract：:Type I interferons (IFN) are important mediators of the host defence against viruses through binding to the cell surface receptors, among which the binding to type I IFN receptor 2 (IFNAR2) is the very first step initiating a complex signal transduction cascade. By using RT-PCR and 5' RACE approaches, we obtained porc...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01018.x

    authors： Xing F,Li Y,Liang S,Liu D,Jiang C,Zhang Y,Kang L,Jiang Y

    更新日期：2011-08-01 00:00:00

  • Reliability of HLA-Cw data collected in unrelated bone marrow registry and their usefulness for preliminary donor selection.

    abstract：:In the present study, we addressed the question of how often HLA-DRB1-matched donors can be found by further typing of AB-matched donors and whether Cw preselection can be helpful. Sixty-eight patients and 174 donors were enrolled in the study. In all donors, confirmatory DNA Cw typing was performed to check reliabili...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00533.x

    authors： Nowak J,Mika-Witkowska R,Zajko M,Łopacz P

    更新日期：2005-10-01 00:00:00

  • Th-1 cytokines gene polymorphism in human brucellosis.

    abstract：:Brucellosis is a worldwide zoonosis. Infection with Brucella species results in the activation of cell-mediated immune response. The interaction between Th1and Th2 cytokines determines the outcome of disease. Production of each cytokine is in turn affected by genetic factors. In this study, we investigated the possibl...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2006.00626.x

    authors： Davoudi S,Amirzargar AA,Hajiabdolbaghi M,Rasoolinejad M,Soodbakhsh A,Jafari S,Piri H,Maleknejad P,Bagherian H,Madadi N,Nikbin B

    更新日期：2006-10-01 00:00:00

  • Using ESTs database to predict and validate single polymorphisms at the HLA system.

    abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.01076.x

    authors： Figueiredo TC,de Oliveira JR

    更新日期：2012-06-01 00:00:00

  • Immunophenotyping in peripheral blood mononuclear cells, aqueous humour and vitreous in a Blau syndrome patient caused by a novel NOD2 mutation.

    abstract：:The genetic and immunophenotypic characteristics of a 3-year-old patient with Blau syndrome (BS), an early onset sarcoidosis caused by mutations in NOD2, were investigated. Molecular analysis of NOD2 gene was achieved by PCR and direct nucleotide sequencing. Immunophenotyping included cytometric analysis of memory-eff...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2011.00998.x

    authors： Jimenez-Martinez MC,Cruz F,Groman-Lupa S,Zenteno JC

    更新日期：2011-06-01 00:00:00

  • A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic loci.

    abstract：:Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/j.1744-313X.2005.00494.x

    authors： Bown MJ,Weston S,Horsburgh T,Nicholson ML,Bell PR,Sayers RD

    更新日期：2005-04-01 00:00:00

  • Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non-coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem).

    abstract：:Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein-1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four s...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12423

    authors： Lobo-Alves SC,de Oliveira LA,Petzl-Erler ML

    更新日期：2019-06-01 00:00:00

  • The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.

    abstract：:The past decade has witnessed hundreds of reports declaring or not being able to replicable genetic association with systemic lupus erythematosus (SLE) susceptibility. BANK1 is a gene that encodes a B-cell-specific scaffold protein and its activation can affect B-cell-receptor-induced calcium mobilization from intrace...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1744-313X.2010.00990.x

    authors： Fan Y,Tao JH,Zhang LP,Li LH,Ye DQ

    更新日期：2011-04-01 00:00:00

  • Association between CCL2 haplotypes and knee osteoarthritis.

    abstract：:We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in t...

    journal_title：International journal of immunogenetics

    pub_type： 杂志文章

    doi：10.1111/iji.12015

    authors： Hulin-Curtis SL,Bidwell JL,Perry MJ

    更新日期：2013-08-01 00:00:00