Cytokine typing: SNP allele frequencies in the Iranian population.

abstract：:It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. However, s...

journal_title：International journal of immunogenetics

authors： Howell WM

更新日期：2014-02-01 00:00:00

abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

journal_title：International journal of immunogenetics

authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

更新日期：2012-06-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...

journal_title：International journal of immunogenetics

authors： da Silva Cezar RD,da Silva Castanha PM,Matos Freire N,Mola C,Feliciano do Carmo R,Tenório Cordeiro M,Baptista P,Silva Vasconcelos LR,Moura P,da Silva Teixeira VG

更新日期：2020-08-01 00:00:00

abstract：:Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...

journal_title：International journal of immunogenetics

authors： Harishankar M,Selvaraj P,Rajeswari DN,Anand SP,Narayanan PR

更新日期：2007-10-01 00:00:00

abstract：:The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism. ...

journal_title：International journal of immunogenetics

authors： Bonatti F,Adorni A,Percesepe A,Martorana D

更新日期：2018-02-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) play an essential role in the control of viral replication during human immunodeficiency virus (HIV) infection. However, the efficacy of the CTL response varies between individuals. We tested the hypothesis that genetic polymorphisms in the lytic effector molecule perforin could influenc...

journal_title：International journal of immunogenetics

authors： McIlroy D,Meyer L,Dudoit Y,Samri A,Delfraissy JF,Autran B,Debré P,Theodorou I

更新日期：2006-04-01 00:00:00

abstract：:We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT a...

journal_title：International journal of immunogenetics

authors： Yang KL,Lee SK,Yang SY,Kao RH,Lin CL,Lin PY

更新日期：2013-04-01 00:00:00

abstract：:Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of g...

journal_title：International journal of immunogenetics

authors： Bown MJ,Weston S,Horsburgh T,Nicholson ML,Bell PR,Sayers RD

更新日期：2005-04-01 00:00:00

abstract：:Nitric oxide (NO) is an endogenous vasodilator involved in inflammatory and autoimmune response, and in the pathophysiology of diabetic vascular disease. Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired...

journal_title：International journal of immunogenetics

authors： Mamoulakis D,Bitsori M,Galanakis E,Vazgiourakis V,Panierakis C,Goulielmos GN

更新日期：2009-06-01 00:00:00

abstract：:Genome-wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases. In addition, emerging evid...

journal_title：International journal of immunogenetics

authors： Polgar N,Csongei V,Szabo M,Zambo V,Melegh BI,Sumegi K,Nagy G,Tulassay Z,Melegh B

更新日期：2012-06-01 00:00:00

abstract：:Illumina first introduced their TruSight human leucocyte antigen (HLA) next-generation sequencing (NGS) typing kit in 2015 and subsequently followed up with a new version in 2016. Here we report on our experience comparing the two versions of the Illumina HLA NGS kits. ...

journal_title：International journal of immunogenetics

authors： Profaizer T,Lázár-Molnár E,Pole A,Delgado JC,Kumánovics A

更新日期：2017-08-01 00:00:00

abstract：:Sunlight/ultraviolet (UV) irradiation has been recognized as an important risk factor for developing systemic lupus erythematosus (SLE). However, the interpretation of genetic variations involved in UV-light sensitivity is largely unknown. Recent studies indicated that two genetic variations of ERCC2/XPD gene (rs17997...

journal_title：International journal of immunogenetics

authors： Wan L,Lin YJ,Sheu JJ,Huang CM,Tsai Y,Tsai CH,Wong W,Tsai FJ

更新日期：2009-02-01 00:00:00

abstract：:In recent years, with the application of genotyping technology, there has been a substantial increase in the number of reported blood group alleles. This survey was designed to evaluate new molecular blood group genotyping methods and compile reference blood group data sets for Polynesian and Maori subjects. Subsequen...

journal_title：International journal of immunogenetics

authors： Edinur HA,Dunn PP,Lea RA,Chambers GK

更新日期：2013-12-01 00:00:00

abstract：:Immunological studies have supported the idea that innate immunity is critical for the control of Mycobacterium tuberculosis (Mtb) infection in humans. Despite the overwhelming evidence showing the critical role of Toll-like receptors (TLRs) in the in vitro recognition of Mtb, the in vivo significance of individual TL...

journal_title：International journal of immunogenetics

authors： Sánchez D,Lefebvre C,Rioux J,García LF,Barrera LF

更新日期：2012-06-01 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen-4 is a cell-surface molecule providing a negative signal for T cell activation. CTLA-4 gene polymorphisms are known to be related with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). However, the effects of this polymorphism...

journal_title：International journal of immunogenetics

authors： Ulker M,Yazisiz V,Sallakci N,Avci AB,Sanlioglu S,Yegin O,Terzioglu E

更新日期：2009-08-01 00:00:00

abstract：:Killer cells immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed mainly by natural killer (NK) cells and few subsets of T lymphocytes. KIRs regulate NK cells' activity through interactions with specific HLA class I molecules and other yet unknown ligands presented on targ...

journal_title：International journal of immunogenetics

authors： Pavlova Y,Kolesar L,Striz I,Jabor A,Slavcev A

更新日期：2008-02-01 00:00:00

abstract：:Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...

journal_title：International journal of immunogenetics

authors： Yavari M,Brinkley G,Klapstein KD,Hartwig WC,Rao R,Hermel E

更新日期：2012-10-01 00:00:00

abstract：:Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presen...

journal_title：International journal of immunogenetics

authors： Lewandowska M,Garczyńska P,Jędrychowska-Dańska K,Kopczyńska P,Masłowska A,Witas H

更新日期：2015-06-01 00:00:00

abstract：:We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine ...

journal_title：International journal of immunogenetics

authors： Frison S,Rinaldini C,Pagoda M,Brambilla C,Poli F

更新日期：2007-02-01 00:00:00

abstract：:Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric s...

journal_title：International journal of immunogenetics

authors： Poole K,Montague B,Roberts R,Stoves J,Bendukidze N,Clark B

更新日期：2006-08-01 00:00:00

abstract：:Immunological inflammatory reaction is one of the key links in the occurrence and development of post-traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN-γ and bone remodelling cells. However, potential association of IFN-γ gene polymorphism with susceptibility ...

journal_title：International journal of immunogenetics

authors： Zhao XQ,Jiang N,Hu YJ,Yu B

更新日期：2020-04-01 00:00:00

abstract：:Mannose binding lectin (MBL) is an important innate immune system pattern recognition molecule. The MBL gene polymorphisms are reported to play a crucial role in outcome of hepatitis B virus (HBV) infection. In this study, we ascertained the association of MBL genotypes with HBV outcome in a South Indian population. T...

journal_title：International journal of immunogenetics

authors： Fletcher GJ,Gnanamony M,Samuel P,Ismail AM,Kannangai R,Daniel D,Eapen CE,Abraham P

更新日期：2010-06-01 00:00:00

abstract：:We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in t...

journal_title：International journal of immunogenetics

authors： Hulin-Curtis SL,Bidwell JL,Perry MJ

更新日期：2013-08-01 00:00:00

abstract：:A new allelic variant in MICB*005 lineage, MICB*005:09, has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR-sequence-based typing (Sanger sequencing) and confirmed by cloning and sequencing. Aligned with MICB*005:03, this new allelic variant shows a synonymous...

journal_title：International journal of immunogenetics

authors： Tursun M,Wang Z,Guo W,Hasim A,Tian W

更新日期：2019-02-01 00:00:00

abstract：:Currently, there is a lack of information on polymorphism of human leucocyte antigen-F (HLA-F) gene in ethnically diverse human populations. In this study, HLA-F allelic typing was performed for 690 individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese pop...

journal_title：International journal of immunogenetics

authors： Pan FH,Liu XX,Tian W

更新日期：2013-10-01 00:00:00

abstract：:Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). ICAM-1 expression is associated with increasing Breslow thickness of vertical growth-phase tumours and, in patients with stage 1 disease, may be associated with disease free...

journal_title：International journal of immunogenetics

authors： Howell WM,Rose-Zerilli MJ,Theaker JM,Bateman AC

更新日期：2005-12-01 00:00:00

abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...

journal_title：International journal of immunogenetics

authors： Figueiredo TC,de Oliveira JR

更新日期：2012-06-01 00:00:00

abstract：:C-reactive protein (CRP) is an inflammation marker implicated in the pathogenesis of schizophrenia. To investigate association of the CRP rs1417938, rs1800947, rs1205 variants with susceptibility to schizophrenia 208 unrelated Armenians (103 patients and 105 healthy controls) were genotyped. In this pilot study, none ...

journal_title：International journal of immunogenetics

authors： Zakharyan R,Chavushyan A,Khoyetsyan A,Stahelova A,Arakelyan A,Boyajyan A,Mrazek F,Petrek M

更新日期：2010-10-01 00:00:00

abstract：:To identify HLA-B*15 subtypes distribution in Han population in Beijing, People's Republic of China, 826 unrelated healthy individuals were typed using the polymerase chain reaction-sequence-based typing method. Within the 246 HLA-B*15 positive individuals, 29 HLA-B*15 alleles were identified, the most predominant of ...

journal_title：International journal of immunogenetics

authors： Yang G,Deng YJ,Qin H,Zhu BF,Chen F,Shen CM,Sun ZM,Chen LP,Wu J,Mu HF,Lucas R

更新日期：2010-06-01 00:00:00

abstract：:The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selecti...

journal_title：International journal of immunogenetics

authors： Martinez-Borra J,Khakoo SI

更新日期：2008-04-01 00:00:00