Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing.

abstract：:The human platelet alloantigen (HPA) 4b allele is rarely observed in Caucasians and the observed incidence in Asians is usually lower than 1.0%. We report the first Brazilian with the allele HPA-4b, and were able to determined that he inherited it from his father. ...

journal_title：International journal of immunogenetics

authors： Toralles-Pereira C,de M C Pardini MI,Deffune E,Machado PE

更新日期：2005-06-01 00:00:00

abstract：:Genome-wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases. In addition, emerging evid...

journal_title：International journal of immunogenetics

authors： Polgar N,Csongei V,Szabo M,Zambo V,Melegh BI,Sumegi K,Nagy G,Tulassay Z,Melegh B

更新日期：2012-06-01 00:00:00

abstract：:We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that...

journal_title：International journal of immunogenetics

authors： Figueiredo TC,de Oliveira JR

更新日期：2012-06-01 00:00:00

abstract：:Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of...

journal_title：International journal of immunogenetics

authors： Yao Q,Fischer KP,Tyrrell DL,Gutfreund KS

更新日期：2015-04-01 00:00:00

abstract：:Matrix metalloproteinase 9 plays an important role in the development of bronchial asthma. We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children. However, we found no asso...

journal_title：International journal of immunogenetics

authors： Ganter K,Deichmann KA,Heinzmann A

更新日期：2005-08-01 00:00:00

abstract：:We have used molecular methods to determine the frequencies of human leukocyte antigen (HLA)-A, -B and -C alleles in normal, healthy, unrelated individuals from North India using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes as there is no comprehensive report showing molecu...

journal_title：International journal of immunogenetics

authors： Rani R,Marcos C,Lazaro AM,Zhang Y,Stastny P

更新日期：2007-06-01 00:00:00

abstract：:Polymorphic Alu insertions (POALINs) are found throughout the human genome and have been used in various studies to infer geographic origin of human populations. The main aim of this study was to determine the allele and haplotype frequencies of five POALINs, AluHF, AluHG, AluHJ, AluTF and AluMICB, within the major hi...

journal_title：International journal of immunogenetics

authors： Kulski JK,Mawart A,Marie K,Tay GK,AlSafar HS

更新日期：2019-08-01 00:00:00

abstract：:The present study aimed to analyse the frequencies of human leukocyte antigen HLA-ABCDQB1 and HLA-DRB1 alleles and haplotypes in a subset of 3,732 Han population from Hubei of China. All samples were typed in the HLA-ABCDQB1 and HLA-DRB1 loci using the sequence-based typing method; subsequently, the HLA polymorphisms ...

journal_title：International journal of immunogenetics

authors： Zou J,Shen G,Qiang W,Zhu YY,Li WX

更新日期：2021-02-01 00:00:00

abstract：:It is now over forty years since the first associations between particular HLA antigens and disease susceptibility were described, and the identification of large numbers HLA-associated diseases parallels our increased understanding of the genetic complexity of the HLA system and its extensive polymorphism. However, s...

journal_title：International journal of immunogenetics

authors： Howell WM

更新日期：2014-02-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT), using unrelated donors (UD), is now a common modality of treatment for individuals with a variety of different diseases. HLA matching has been shown to have a significant impact on patient outcome. This study includes 423 unrelated UK patient/donor pairs. The patients a...

journal_title：International journal of immunogenetics

authors： Shaw BE

更新日期：2008-08-01 00:00:00

abstract：:Killer cells immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed mainly by natural killer (NK) cells and few subsets of T lymphocytes. KIRs regulate NK cells' activity through interactions with specific HLA class I molecules and other yet unknown ligands presented on targ...

journal_title：International journal of immunogenetics

authors： Pavlova Y,Kolesar L,Striz I,Jabor A,Slavcev A

更新日期：2008-02-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is an autoimmune bullous epidermal disease, characterized by autoantibodies specific to the desmosomal protein desmoglein 1 (dsg1) and by acantholysis, the rupture of the cellular junctions among keratinocytes. Known also as fogo selvagem (wild fire) in Brazil, the disease has distinct epidemi...

journal_title：International journal of immunogenetics

authors： Köhler KF,Petzl-Erler ML

更新日期：2006-04-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) play an essential role in the control of viral replication during human immunodeficiency virus (HIV) infection. However, the efficacy of the CTL response varies between individuals. We tested the hypothesis that genetic polymorphisms in the lytic effector molecule perforin could influenc...

journal_title：International journal of immunogenetics

authors： McIlroy D,Meyer L,Dudoit Y,Samri A,Delfraissy JF,Autran B,Debré P,Theodorou I

更新日期：2006-04-01 00:00:00

abstract：:The Toll-like receptors (TLRs) are related to innate immunity. TLR9, a member of TLRs, is expressed in immune cell-rich tissues and mediates cellular response. We investigated the association between TLR9 polymorphisms and kidney allograft outcomes. To investigate whether TLR9 polymorphisms are associated with acute r...

journal_title：International journal of immunogenetics

authors： Kim TH,Jeong KH,Kim SK,Lee SH,Ihm CG,Lee TW,Moon JY,Yoon YC,Chung JH,Park SJ,Kang SW,Kim YH

更新日期：2013-12-01 00:00:00

abstract：:Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotyp...

journal_title：International journal of immunogenetics

authors： Harishankar M,Selvaraj P,Rajeswari DN,Anand SP,Narayanan PR

更新日期：2007-10-01 00:00:00

abstract：:Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which mainly affects the skin and nervous system. The disease has several clinical forms. This study investigated the MICA and HLA-B genes in 223 samples from leprosy patients and 201 samples from healthy individuals matched for age, gender and et...

journal_title：International journal of immunogenetics

authors： do Sacramento WS,Mazini PS,Franceschi DA,de Melo FC,Braga MA,Sell AM,Tsuneto LT,Visentainer JE

更新日期：2012-06-01 00:00:00

abstract：:In the present study, DNA typing for human leucocyte antigen (HLA)-DPB1, -DRB1, and -DQB1 was performed using polymerase chain reaction-sequence-based-typing (PCR-SBT) method on 94 randomly selected, healthy, unrelated individuals from the Ewenki ethnic population in Inner Mongolia Autonomous Region of China. A total ...

journal_title：International journal of immunogenetics

authors： Su X,Bi L,Hai R,Qimuge S,Ying M,Bahring S,Gong M

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS). The design is the genetic case-control association study. Microsatellite and the TNF promoter region polymorphisms wer...

journal_title：International journal of immunogenetics

authors： Silva MM,Simões RT,Castelli EC,Mendes-Junior CT,Deghaide NH,Tsuda LC,Machado AA,Donadi EA,Fernandes AP

更新日期：2010-10-01 00:00:00

abstract：:In the present study, we addressed the question of how often HLA-DRB1-matched donors can be found by further typing of AB-matched donors and whether Cw preselection can be helpful. Sixty-eight patients and 174 donors were enrolled in the study. In all donors, confirmatory DNA Cw typing was performed to check reliabili...

journal_title：International journal of immunogenetics

authors： Nowak J,Mika-Witkowska R,Zajko M,Łopacz P

更新日期：2005-10-01 00:00:00

abstract：:We have characterized the HLA-A, -B, -DRB1, -DQA1 and -DQB1 profiles of three major ethnic groups living in Chelyabinsk Region of Russian South Urals, viz., Russians (n = 207), Bashkirs (n = 146) and Tatars (n = 135). First field level typing was performed by PCR using sequence-specific primers. Estimates included car...

journal_title：International journal of immunogenetics

authors： Suslova TA,Burmistrova AL,Chernova MS,Khromova EB,Lupar EI,Timofeeva SV,Devald IV,Vavilov MN,Darke C

更新日期：2012-10-01 00:00:00

abstract：:We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine ...

journal_title：International journal of immunogenetics

authors： Frison S,Rinaldini C,Pagoda M,Brambilla C,Poli F

更新日期：2007-02-01 00:00:00

abstract：:According to the IMGT/HLA Database, the DNA sequence of A*11:53 is identical to A*11:02:01 in exons 2, 3, 4 and 5 except at codon 276. A*11:53 was reported as a rare variant of A*11, while A*11:02:01 was understood to be the second most frequently observed variant of A*11 after A*11:01:01 in Taiwanese. We sequenced HL...

journal_title：International journal of immunogenetics

authors： Yang KL,Chu CC,Marsh SG,Lin PY

更新日期：2012-12-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symp...

journal_title：International journal of immunogenetics

authors： da Silva Cezar RD,da Silva Castanha PM,Matos Freire N,Mola C,Feliciano do Carmo R,Tenório Cordeiro M,Baptista P,Silva Vasconcelos LR,Moura P,da Silva Teixeira VG

更新日期：2020-08-01 00:00:00

abstract：:Most humans lack a functional CASP12 gene, with the nonfunctional variant (CASP12p1), found in 100% of the Caucasian and east Asian population, and in approximately 80% of people of African descent. However, 20% of Africans carry an intact allele of CASP12, which produces a full-length pro-enzyme and increases the ris...

journal_title：International journal of immunogenetics

authors： Yavari M,Brinkley G,Klapstein KD,Hartwig WC,Rao R,Hermel E

更新日期：2012-10-01 00:00:00

abstract：:This study assessed the phenotypic and allelic profiles of ABO and Rhesus D blood group system among first time blood donors at the National Centre of Blood Supply of Antananarivo. We collected through this retrospective study all data registered during 7 years of practice (from 2003 to 2009). Age and sex were analyse...

journal_title：International journal of immunogenetics

authors： Randriamanantany ZA,Rajaonatahina DH,Razafimanantsoa FE,Rasamindrakotroka MT,Andriamahenina R,Rasoarilalamanarivo FB,Hanitriniala SP,Herisoa FR,Rasamindrakotroka A,Rakoto Alson OA

更新日期：2012-12-01 00:00:00

abstract：:Single nucleotide polymorphisms within the promoter or other regulatory sequences of cytokine genes were evaluated and compared between an Iranian population and populations of different ethnic/geographical background. In 40 healthy Iranian subjects, cytokine typing was performed by polymerase chain reaction-sequence-...

journal_title：International journal of immunogenetics

authors： Bagheri M,Abdi-Rad I,Omrani D,Khalkhali HR

更新日期：2006-06-01 00:00:00

abstract：:Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They ...

journal_title：International journal of immunogenetics

authors： Seyhun Y,Ciftci HS,Kekik C,Karadeniz MS,Tefik T,Nane I,Turkmen A,Oguz FS,Aydin F

更新日期：2015-06-01 00:00:00

abstract：:Catalase (CAT) is an antioxidant enzyme and plays a significant role in the protection against oxidative stress by reducing hydrogen peroxide. The CAT cDNA of Eriocheir sinensis (EsCAT) was cloned via RACE technique. The complete sequence of EsCAT cDNA consisted of a 5' untranslated regions (UTR) of 224 bp, a 3' UTR o...

journal_title：International journal of immunogenetics

authors： Wang M,Wang L,Zhou Z,Gao Y,Wang L,Shi X,Gai Y,Mu C,Song L

更新日期：2013-06-01 00:00:00

abstract：:Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presen...

journal_title：International journal of immunogenetics

authors： Lewandowska M,Garczyńska P,Jędrychowska-Dańska K,Kopczyńska P,Masłowska A,Witas H

更新日期：2015-06-01 00:00:00

abstract：:The African buffalo (Syncerus caffer) has been implicated as the reservoir of several bovine infectious agents. However, there is insufficient information on the protective immune responses in the African buffalo, particularly in infected animals. In this study, we analysed Th1 cytokines IL-2 and IFN-γ, and Th2 cytoki...

journal_title：International journal of immunogenetics

authors： Suzuki S,Konnai S,Okagawa T,Githaka NW,Kariuki E,Gakuya F,Kanduma E,Shirai T,Ikebuchi R,Ikenaka Y,Ishizuka M,Murata S,Ohashi K

更新日期：2012-04-01 00:00:00