Abstract:
:Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondroma as well as rare tumors such as chondroblastoma and chondromyxoid fibroma. Several benign and malignant tumors may mimic benign cartilaginous tumors of bones. We reviewed the main morphologic features and the differential diagnosis is discussed. The genetics of these tumors is intriguing ranging from single gene event (ie, EXT mutation in multiple osteochondromas) to heterogeneous rearrangements with no recurrent involved chromosomal regions such as in chondroblastoma. The main genetic findings are hereby reviewed.
journal_name
Adv Anat Patholjournal_title
Advances in anatomic pathologyauthors
Romeo S,Hogendoorn PC,Dei Tos APdoi
10.1097/PAP.0b013e3181b506a1subject
Has Abstractpub_date
2009-09-01 00:00:00pages
307-15issue
5eissn
1072-4109issn
1533-4031pii
00125480-200909000-00004journal_volume
16pub_type
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