Oncofetal protein IMP3, a new cancer biomarker.

abstract：:Fluorescence in-situ hybridization (FISH) has arisen as a novel ancillary test for the pathological diagnosis of melanoma. It is an outgrowth of studies using comparative genomic hybridization, a technique capable of surveying the entire genome for DNA copy number changes. An original report published in 2009 showed h...

journal_title：Advances in anatomic pathology

authors： Song J,Mooi WJ,Petronic-Rosic V,Shea CR,Stricker T,Krausz T

更新日期：2011-05-01 00:00:00

abstract：:Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chr...

journal_title：Advances in anatomic pathology

authors： Toper MH,Sarioglu S

更新日期：2021-01-04 00:00:00

abstract：:Intrahepatic ductular reaction is a pathologic proliferation of phenotypical biliary channels. Ductular reactions aim to restore compromised physiological function after liver injury and are one of the archetypal responses of the liver to a wide variety of etiologies, among them are parenchymal loss, biliary tract dis...

journal_title：Advances in anatomic pathology

authors： Jain R,Clark I

更新日期：2021-01-19 00:00:00

abstract：:This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...

journal_title：Advances in anatomic pathology

authors： Stelow EB,French CA

更新日期：2009-03-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER-2) is over-expressed in 15% to 30% of breast cancers and is a poor prognostic marker in node-positive patients. HER-2 expression is an indicator of greater sensitivity to anthracycline-based chemotherapy and is the major criterion for selection for treatment with the anti-...

journal_title：Advances in anatomic pathology

authors： Leong TY,Leong AS

更新日期：2006-09-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor ...

journal_title：Advances in anatomic pathology

authors： Young AN,Master VA,Paner GP,Wang MD,Amin MB

更新日期：2008-01-01 00:00:00

abstract：:Approximately 25% of patients with stage I (node negative) breast cancer relapse at a rate similar to those with stage II disease. Inadvertent pathologic "understaging" of lymph node status is one plausible explanation for this phenomenon. While many studies have shown that additional sectioning +/- immunohistochemica...

journal_title：Advances in anatomic pathology

authors： Mies C,Schlesselman JJ

更新日期：2000-05-01 00:00:00

abstract：:Leukoplakia as a medical term has been encumbered by a hodgepodge of synonyms and interpretations. It also has been a term associated with strong emotions with respect to an implied malignant potential. It now is regarded as potentially malignant, with varying degrees of risk for transformation. Leukoplakia at its maj...

journal_title：Advances in anatomic pathology

authors： Suarez P,Batsakis JG,el-Naggar AK

更新日期：1998-05-01 00:00:00

abstract：:Central nervous system (CNS) neoplasms can be diagnostically challenging, due to remarkably wide ranges in histologic appearance, biologic behavior, and therapeutic approach. Nevertheless, accurate diagnosis is the critical first step in providing optimal patient care. As with other oncology-based specialties, there i...

journal_title：Advances in anatomic pathology

authors： Fuller CE,Perry A

更新日期：2005-07-01 00:00:00

abstract：:Nasopharyngeal angiofibromas (NA) are rare tumor-like lesions characterized by architecturally irregular vessels set in a fibrous stroma. The unique morphology, the strong predilection for male adolescents, and the uncertainty about its etiology contributes to significant confusion regarding the classification of NA, ...

journal_title：Advances in anatomic pathology

authors： Beham A,Beham-Schmid C,Regauer S,Auböck L,Stammberger H

更新日期：2000-01-01 00:00:00

abstract：:The diagnosis of minimal prostatic adenocarcinoma can be challenging on prostate needle biopsy, and immunohistochemistry may be used to support the diagnosis of cancer. The International Society of Urologic Pathology currently recommends the use of the basal cell markers high-molecular-weight cytokeraratin and p63, an...

journal_title：Advances in anatomic pathology

authors： Giannico GA,Arnold SA,Gellert LL,Hameed O

更新日期：2017-01-01 00:00:00

abstract：:Inflammatory osteolysis is a relatively frequent and incapacitating complication of rheumatoid arthritis and other inflammatory diseases, and is induced by accelerated osteoclast recruitment and activation in bone under the aegis of cytokines produced in the inflammatory environment. The success of antitumor necrosis ...

journal_title：Advances in anatomic pathology

authors： Wei S,Siegal GP

更新日期：2007-01-01 00:00:00

abstract：:The analysis of a large number of tumor tissues with conventional techniques of molecular pathology is tedious and slow. The authors recently developed the tissue microarray technology that makes it possible to sample up to 1,000 tumors on one glass slide, which then can be analyzed by fluorescence in situ hybridizati...

journal_title：Advances in anatomic pathology

authors： Moch H,Kononen T,Kallioniemi OP,Sauter G

更新日期：2001-01-01 00:00:00

abstract：:Recent advances in immunohistochemistry have made it possible to investigate lymphomas for the expression of a wide range of antigens in fixed tissues. Epitope retrieval, sensitive detection methods, and the availability of new monoclonal antibodies have all contributed to one's ability to perform detailed immunopheno...

journal_title：Advances in anatomic pathology

authors： Hsi ED,Yegappan S

更新日期：2001-07-01 00:00:00

abstract：:The development of small-molecule inhibitors of the epidermal growth factor receptor (EGFR) resulted in new therapeutic options for patients with advanced lung cancer. It was clear from the experience with targeted therapy for breast cancer that a new standardized assay procedure for assessing and predicting the effec...

journal_title：Advances in anatomic pathology

authors： Dacic S

更新日期：2008-07-01 00:00:00

abstract：:Intraoperative consultation remains an invaluable tool in the initial evaluation of surgically excised specimens. Good communication is required between the pathologist and surgeon to obtain the best care for their mutual patient. Intraoperative consultation (frozen section, FS) provides a preliminary diagnosis for th...

journal_title：Advances in anatomic pathology

authors： Somerset HL,Kleinschmidt-DeMasters BK

更新日期：2011-11-01 00:00:00

abstract：:Descriptions of poorly differentiated thyroid carcinomas, tumors with outcomes midway between that associated with well-differentiated and anaplastic carcinomas, have been prominent in the literature of the recent past. The neoplasms are characterized by the finding of poorly differentiated areas within papillary and ...

journal_title：Advances in anatomic pathology

authors： Nishiyama RH

更新日期：1999-09-01 00:00:00

abstract：:Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are oc...

journal_title：Advances in anatomic pathology

authors： Garg K,Soslow RA

更新日期：2012-01-01 00:00:00

abstract：:The common sources of ionizing radiation exposure to the thyroid gland in humans are accidental environmental exposure and medical, therapeutic, or diagnostic irradiation. Radiation often induces notable histologic changes in the thyroid tissue and is a well-established risk factor for benign and malignant thyroid tum...

journal_title：Advances in anatomic pathology

authors： Nikiforov YE,Gnepp DR

更新日期：1999-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a broad term that includes liver diseases characterized by abnormal hepatocellular accumulations of lipid that cannot be related to alcohol abuse. It may be found in both adults and children, particularly those who are obese or have insulin resistance. Steatohepatitis is a ...

journal_title：Advances in anatomic pathology

authors： Aly FZ,Kleiner DE

更新日期：2011-07-01 00:00:00

abstract：:Endometrial endometrioid adenocarcinoma (EEC) is the most common malignancy of the female genital tract, partly attributable to chronic estrogen exposure secondary to increased obesity rates. Tumor stage, which in most cases is based on depth of invasion (DOI), is of critical importance in determining if additional tr...

journal_title：Advances in anatomic pathology

authors： Cole AJ,Quick CM

更新日期：2013-05-01 00:00:00

abstract：:Digital imaging has progressed at a rapid rate and is likely to eventually replace chemical photography in most areas of professional and amateur digital image acquisition. In pathology, digital microscopy has implications beyond that of taking a photograph. The arguments for adopting this new medium are compelling, a...

journal_title：Advances in anatomic pathology

authors： Leong FJ,Leong AS

更新日期：2003-03-01 00:00:00

abstract：:Invasive micropapillary carcinoma has been recently recognized as a rare but distinctive variant of carcinoma in various anatomic sites, including breast, urinary bladder, lung, and major salivary glands. Morphologically, it is characterized by small tight clusters of neoplastic cells floating in clear spaces resembli...

journal_title：Advances in anatomic pathology

authors： Nassar H

更新日期：2004-11-01 00:00:00

abstract：:Evaluation of the endometrial biopsy is a challenge to practicing pathologists, largely due to the wide range of morphologic patterns resulting from both normal and abnormal cyclic changes, exogenous hormones, infections, and intrauterine tumors. Successfully addressing these challenges requires that the practitioner ...

journal_title：Advances in anatomic pathology

authors： Crum CP,Hornstein MD,Nucci MR,Mutter GL

更新日期：2003-11-01 00:00:00

abstract：:Myoepithelial neoplasms represent a heterogeneous group of tumors of which classification is incomplete and evolving. Those of the soft tissues often form genetically distinct subgroups that differ from those arising within salivary glands. Soft-tissue myoepithelial tumors (including mixed tumors that show true glandu...

journal_title：Advances in anatomic pathology

authors： Thway K,Fisher C

更新日期：2014-11-01 00:00:00

abstract：:Gastrointestinal (GI) tract tumors with melanocytic differentiation may present significant diagnostic challenges both for the pathologist and the clinician. This comprehensive review discusses the relatively common as well as rare entities that have melanocytic differentiation in the GI tract. Clinical, histologic, i...

journal_title：Advances in anatomic pathology

authors： Karamchandani DM,Patil DT,Goldblum JR

更新日期：2013-11-01 00:00:00

abstract：:Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathol...

journal_title：Advances in anatomic pathology

authors： Datta MW,True LD,Nelson PS,Amin MB

更新日期：2007-11-01 00:00:00

abstract：:The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis ...

journal_title：Advances in anatomic pathology

authors： Hunt JL,Ferlito A,Hellquist H,Rinaldo A,Skálová A,Slootweg PJ,Willems SM,Cardesa A

更新日期：2017-05-01 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is an intermediate-grade malignancy of follicular dendritic cells, which are derived from mesenchymal stem cells. Nodal FDCS is well-recognized. However, when it occurs at an extranodal site, it may not be recognized and is often misdiagnosed. These tumors exhibit a variable sp...

journal_title：Advances in anatomic pathology

authors： Kaur R,Mehta J,Borges A

更新日期：2021-01-01 00:00:00

abstract：:CD 117 (KIT) is a transmembrane, tyrosine kinase growth factor receptor which is expressed on numerous diverse fetal and adult cells including hematopoietic cells, mast cells, melanocytes, germ cells, and the interstitial cells of Cajal. Its expression in tumors is also diverse, but with selective use and attention to...

journal_title：Advances in anatomic pathology

authors： Gibson PC,Cooper K

更新日期：2002-01-01 00:00:00