Abstract:
:Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathologic, and outcomes parameters. In this review, we examine the effect of TMA use on prostate cancer biomarker research, focusing on the types of TMAs that have been used, and the biomarkers that have been examined. The results demonstrate that TMAs have been very effective in screening candidate biomarkers for subsequent, extended evaluation in large patient populations. In addition, the use of TMAs in multiple biomarker series allows for the statistical analysis of sets of biomarkers as diagnostic or prognostic tests. The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction.
journal_name
Adv Anat Patholjournal_title
Advances in anatomic pathologyauthors
Datta MW,True LD,Nelson PS,Amin MBdoi
10.1097/PAP.0b013e318155709asubject
Has Abstractpub_date
2007-11-01 00:00:00pages
408-18issue
6eissn
1072-4109issn
1533-4031pii
00125480-200711000-00003journal_volume
14pub_type
杂志文章,评审abstract::This article reviews the recent dermatopathology literature regarding cutaneous adnexal neoplasms, with emphasis on new and underrecognized entities, "old entities" with new findings, advances in immunohistochemistry, and new findings in relation to inherited disorders associated with cutaneous adnexal neoplasms. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182a28a3f
更新日期:2013-09-01 00:00:00
abstract::We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000068
更新日期:2015-05-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181594720
更新日期:2008-01-01 00:00:00
abstract::Ocular adnexal lymphomas comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of extranodal lymphomas. They are a heterogeneous group of malignancies, the majority of which are primary extranodal lymphoma with most (up to 80%) of the marginal zone of mucosa associated lymphoid tissue type (MALT lymphoma). This ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181e4abdb
更新日期:2010-07-01 00:00:00
abstract::Pathology has benefited from advanced innovation with novel technology to implement a digital solution. Whole slide imaging is a disruptive technology where glass slides are scanned to produce digital images. There have been significant advances in whole slide scanning hardware and software that have allowed for ready...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000273
更新日期:2020-07-01 00:00:00
abstract::This paper reviews the pathologic features of lesions which are oncocytic and involve classic endocrine organs. The history of the oncocytic cell, its morphologic and ultrastructural features, and important immunohistochemical findings are reviewed. Oncocytic proliferations including non-neoplastic and neoplastic of t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000011
更新日期:2014-03-01 00:00:00
abstract::This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31819923e4
更新日期:2009-03-01 00:00:00
abstract::As genomic characterization becomes increasingly necessary for accurate diagnosis of tumors of the central nervous system, identification of rapidly assessible biomarkers is equally important to avoid excessive cost and delay in initiation of therapy. This article reviews novel immunohistochemical markers that may be ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000225
更新日期:2020-05-01 00:00:00
abstract::The concept of Waldenstrom macroglobulinemia has evolved from the original description of a clinical syndrome to its more recent designation as a distinct clinicopathologic entity, that is, lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM), in the World Health Organization (WHO) classification and by t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000184176.65919.17
更新日期:2005-09-01 00:00:00
abstract::This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly dif...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000201
更新日期:2019-01-01 00:00:00
abstract::The topic of hereditary gynecologic malignancies readily evokes associations between Lynch syndrome and endometrial adenocarcinoma, or between BRCA mutations and tubo-ovarian serous carcinoma, but other familial associations are less well-known. Two hereditary syndromes are known to be related to uterine mesenchymal t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000175
更新日期:2018-03-01 00:00:00
abstract::Digital pathology systems offer pathologists an alternate, emerging mechanism to manage and interpret information. They offer increasingly fast and scalable hardware platforms for slide scanning and software that facilitates remote viewing, slide conferencing, archiving, and image analysis. Deployed initially and vali...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318253459e
更新日期:2012-05-01 00:00:00
abstract::CD 117 (KIT) is a transmembrane, tyrosine kinase growth factor receptor which is expressed on numerous diverse fetal and adult cells including hematopoietic cells, mast cells, melanocytes, germ cells, and the interstitial cells of Cajal. Its expression in tumors is also diverse, but with selective use and attention to...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200201000-00007
更新日期:2002-01-01 00:00:00
abstract::The estrogen receptor (ER) is a regulator of cellular growth, proliferation, and differentiation. In addition to having prognostic value, ER is the most important biologic marker of therapeutic response in breast cancer. Some level of measurable ER protein is expressed in 70-80% of human breast. Immunohistochemistry i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200501000-00003
更新日期:2005-01-01 00:00:00
abstract::Desmoplastic melanoma (DM) is a relatively rare cytomorphologic variant of melanoma with a marked propensity for perineural invasion (PNI). Historically, DMs that display PNI have been grouped under the umbrella term of neurotropic melanoma (NM). However, definitions for NM and desmoplastic NM are not consistent in th...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000076
更新日期:2015-07-01 00:00:00
abstract::Fluorescence in-situ hybridization (FISH) has arisen as a novel ancillary test for the pathological diagnosis of melanoma. It is an outgrowth of studies using comparative genomic hybridization, a technique capable of surveying the entire genome for DNA copy number changes. An original report published in 2009 showed h...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182169b69
更新日期:2011-05-01 00:00:00
abstract::Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic but several non-neoplastic conditions are also composed of spindle cells. This review discusses the main differential diagnoses of an ovarian spindle cell lesion, especially concentrating on the recent literature. The majorit...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3180ca8a5b
更新日期:2007-09-01 00:00:00
abstract::Endometrial endometrioid adenocarcinoma (EEC) is the most common malignancy of the female genital tract, partly attributable to chronic estrogen exposure secondary to increased obesity rates. Tumor stage, which in most cases is based on depth of invasion (DOI), is of critical importance in determining if additional tr...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31828d17cc
更新日期:2013-05-01 00:00:00
abstract::Myoepithelial neoplasms represent a heterogeneous group of tumors of which classification is incomplete and evolving. Those of the soft tissues often form genetically distinct subgroups that differ from those arising within salivary glands. Soft-tissue myoepithelial tumors (including mixed tumors that show true glandu...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000039
更新日期:2014-11-01 00:00:00
abstract::Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondro...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181b506a1
更新日期:2009-09-01 00:00:00
abstract::This manuscript presents a review of infectious causes of gastritis aimed at the practicing anatomic pathologist. We shall highlight unique histologic findings and clinical attributes that will assist those analyzing endoscopically obtained mucosal biopsies of the stomach or resection specimens. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000187
更新日期:2018-07-01 00:00:00
abstract::Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reach...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000168
更新日期:2018-01-01 00:00:00
abstract::Immunohistochemistry (IHC) is routinely performed in most laboratories, and other than purchase of commercially available antibodies, requires no additional equipment or reagents. As such, IHC is an accessible and relatively inexpensive test and one that can be performed quite quickly. This is in sharp contrast to gen...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000246
更新日期:2019-11-01 00:00:00
abstract::Approximately 25% of patients with stage I (node negative) breast cancer relapse at a rate similar to those with stage II disease. Inadvertent pathologic "understaging" of lymph node status is one plausible explanation for this phenomenon. While many studies have shown that additional sectioning +/- immunohistochemica...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-200007030-00003
更新日期:2000-05-01 00:00:00
abstract::The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000147
更新日期:2017-05-01 00:00:00
abstract::Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of n...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000003
更新日期:2014-01-01 00:00:00
abstract::Well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL) form the largest subgroup of liposarcomas, and represent a morphologic and behavioral spectrum of 1 disease entity, which arises typically in middle to late adult life, most frequently within the retroperitoneum or extremities. DDL is defined...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000101
更新日期:2016-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) has distinct morphologic features and can be identified in the majority of cases by routine hematoxylin and eosin (H&E)-stained formalin-fixed paraffin-embedded sections. However, distinguishing a well-differentiated HCC from normal or regenerative tissue may be very difficult in some ca...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000131822.31576.9d
更新日期:2004-09-01 00:00:00
abstract::In this review, a recently published pattern-based risk stratification system of endocervical adenocarcinoma (EAC) is presented. This novel system evaluates the morphologic features of the tumor and establishes patterns that are associated with a particular tumor behavior. Patients with pattern A EAC do not develop ly...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000097
更新日期:2015-11-01 00:00:00
abstract::A variety of arthropods, protozoa, and helminths infect the skin and subcutaneous tissues and may be identified by anatomic pathologists in standard cytology and histology preparations. The specific organisms seen vary greatly with the patient's exposure history, including travel to or residence in endemic countries. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000183
更新日期:2018-03-01 00:00:00