Detection of "occult" lymph node metastasis in breast cancer: should pathologists go the extra mile?

abstract：:Desmoplastic melanoma (DM) is a relatively rare cytomorphologic variant of melanoma with a marked propensity for perineural invasion (PNI). Historically, DMs that display PNI have been grouped under the umbrella term of neurotropic melanoma (NM). However, definitions for NM and desmoplastic NM are not consistent in th...

journal_title：Advances in anatomic pathology

authors： Frydenlund N,Mahalingam M

更新日期：2015-07-01 00:00:00

abstract：:The common sources of ionizing radiation exposure to the thyroid gland in humans are accidental environmental exposure and medical, therapeutic, or diagnostic irradiation. Radiation often induces notable histologic changes in the thyroid tissue and is a well-established risk factor for benign and malignant thyroid tum...

journal_title：Advances in anatomic pathology

authors： Nikiforov YE,Gnepp DR

更新日期：1999-03-01 00:00:00

abstract：:We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...

journal_title：Advances in anatomic pathology

authors： Galliani CA,Sanchez IC,D'Errico MM,Bisceglia M

更新日期：2015-05-01 00:00:00

abstract：:Gliomas are a large and diverse group of primary brain tumors that include those that are diffusely infiltrative and others that are well-circumscribed and low grade. Diffuse gliomas are currently classified by the World Health Organization as astrocytomas, oligodendrogliomas, or oligoastrocytomas and range in grade f...

journal_title：Advances in anatomic pathology

authors： Appin CL,Brat DJ

更新日期：2015-01-01 00:00:00

abstract：:This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly dif...

journal_title：Advances in anatomic pathology

authors： Guilmette JM,Nosé V

更新日期：2019-01-01 00:00:00

abstract：:Pancreatic cancer is an aggressive disease with a dismal prognosis in dire need of novel diagnostic and therapeutic approaches. The past decade has witnessed an explosion of data on the genetic alterations that occur in pancreatic cancer, as comprehensive next-generation sequencing analyses have been performed on samp...

journal_title：Advances in anatomic pathology

authors： Felsenstein M,Hruban RH,Wood LD

更新日期：2018-03-01 00:00:00

abstract：:Leukoplakia as a medical term has been encumbered by a hodgepodge of synonyms and interpretations. It also has been a term associated with strong emotions with respect to an implied malignant potential. It now is regarded as potentially malignant, with varying degrees of risk for transformation. Leukoplakia at its maj...

journal_title：Advances in anatomic pathology

authors： Suarez P,Batsakis JG,el-Naggar AK

更新日期：1998-05-01 00:00:00

abstract：:Inflammatory skin diseases encompass a vast array of conditions. The field continues to expand and evolve with resurgence of conditions, through newly recognized medication adverse effects, and via more detailed descriptions of known dermatoses. The importance of clinicopathologic correlation and an up to date knowled...

journal_title：Advances in anatomic pathology

authors： Penn L,Rothman L,Sutton AM,Brinster NK,Vidal CI

更新日期：2019-01-01 00:00:00

abstract：:Our understanding of the natural history of breast cancer has evolved alongside technologies to study its genomic, transcriptomic, proteomic, and metabolomics landscapes. These technologies have helped decipher multiple molecular pathways dysregulated in breast cancer. First-generation 'omics analyses considered each ...

journal_title：Advances in anatomic pathology

authors： Kalita-de Croft P,Al-Ejeh F,McCart Reed AE,Saunus JM,Lakhani SR

更新日期：2016-11-01 00:00:00

abstract：:The concept of Waldenstrom macroglobulinemia has evolved from the original description of a clinical syndrome to its more recent designation as a distinct clinicopathologic entity, that is, lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM), in the World Health Organization (WHO) classification and by t...

journal_title：Advances in anatomic pathology

authors： Lin P,Medeiros LJ

更新日期：2005-09-01 00:00:00

abstract：:Alveolar soft-part sarcoma (ASPS) is one of the most unusual of the soft tissue sarcomas. Although it most commonly arises in the fascial planes or skeletal muscles of the lower extremities in adults, and in the head and neck region in children, it has also been documented in extraskeletal muscle locations, especially...

journal_title：Advances in anatomic pathology

authors： Ordóñez NG

更新日期：1999-05-01 00:00:00

abstract：:Digital imaging has progressed at a rapid rate and is likely to eventually replace chemical photography in most areas of professional and amateur digital image acquisition. In pathology, digital microscopy has implications beyond that of taking a photograph. The arguments for adopting this new medium are compelling, a...

journal_title：Advances in anatomic pathology

authors： Leong FJ,Leong AS

更新日期：2003-03-01 00:00:00

abstract：:Paratesticular mesotheliomas are rare tumors with 223 cases described so far. The sole plausible causative factor so far ascertained in the pathogenesis of these tumors is asbestos, which however is found in only around 30% to 40% of such cases. The age range of affected individuals is wide, mostly adults and the elde...

journal_title：Advances in anatomic pathology

authors： Bisceglia M,Dor DB,Carosi I,Vairo M,Pasquinelli G

更新日期：2010-01-01 00:00:00

abstract：:Endometrial endometrioid adenocarcinoma (EEC) is the most common malignancy of the female genital tract, partly attributable to chronic estrogen exposure secondary to increased obesity rates. Tumor stage, which in most cases is based on depth of invasion (DOI), is of critical importance in determining if additional tr...

journal_title：Advances in anatomic pathology

authors： Cole AJ,Quick CM

更新日期：2013-05-01 00:00:00

abstract：:The development of small-molecule inhibitors of the epidermal growth factor receptor (EGFR) resulted in new therapeutic options for patients with advanced lung cancer. It was clear from the experience with targeted therapy for breast cancer that a new standardized assay procedure for assessing and predicting the effec...

journal_title：Advances in anatomic pathology

authors： Dacic S

更新日期：2008-07-01 00:00:00

abstract：:Fluorescence in-situ hybridization (FISH) has arisen as a novel ancillary test for the pathological diagnosis of melanoma. It is an outgrowth of studies using comparative genomic hybridization, a technique capable of surveying the entire genome for DNA copy number changes. An original report published in 2009 showed h...

journal_title：Advances in anatomic pathology

authors： Song J,Mooi WJ,Petronic-Rosic V,Shea CR,Stricker T,Krausz T

更新日期：2011-05-01 00:00:00

abstract：:Well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL) form the largest subgroup of liposarcomas, and represent a morphologic and behavioral spectrum of 1 disease entity, which arises typically in middle to late adult life, most frequently within the retroperitoneum or extremities. DDL is defined...

journal_title：Advances in anatomic pathology

authors： Thway K,Jones RL,Noujaim J,Zaidi S,Miah AB,Fisher C

更新日期：2016-01-01 00:00:00

abstract：:This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...

journal_title：Advances in anatomic pathology

authors： Stelow EB,French CA

更新日期：2009-03-01 00:00:00

abstract：:This manuscript presents a review of infectious causes of gastritis aimed at the practicing anatomic pathologist. We shall highlight unique histologic findings and clinical attributes that will assist those analyzing endoscopically obtained mucosal biopsies of the stomach or resection specimens. ...

journal_title：Advances in anatomic pathology

authors： Yee EU,Kuo E,Goldsmith JD

更新日期：2018-07-01 00:00:00

abstract：:Inflammatory osteolysis is a relatively frequent and incapacitating complication of rheumatoid arthritis and other inflammatory diseases, and is induced by accelerated osteoclast recruitment and activation in bone under the aegis of cytokines produced in the inflammatory environment. The success of antitumor necrosis ...

journal_title：Advances in anatomic pathology

authors： Wei S,Siegal GP

更新日期：2007-01-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor ...

journal_title：Advances in anatomic pathology

authors： Young AN,Master VA,Paner GP,Wang MD,Amin MB

更新日期：2008-01-01 00:00:00

abstract：:Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are oc...

journal_title：Advances in anatomic pathology

authors： Garg K,Soslow RA

更新日期：2012-01-01 00:00:00

abstract：:Epithelioid hemangioendothelioma is a vascular tumor of low to intermediate malignancy that was initially described in the soft tissue. Since then, epithelioid hemangioendothelioma has been described in various anatomic sites including parenchymal tissues and the bone. In the bone, these tumors must not only be distin...

journal_title：Advances in anatomic pathology

authors： Weissferdt A,Moran CA

更新日期：2014-07-01 00:00:00

abstract：:The Bethesda System for Reporting Thyroid Cytopathology is a standardized reporting system for classifying thyroid fine-needle aspiration results comprising of 6 diagnostic categories with unique risks of malignancy and recommendations for clinical management. The majority of thyroid nodules are benign; however, up to...

journal_title：Advances in anatomic pathology

authors： Wong LQ,Baloch ZW

更新日期：2012-09-01 00:00:00

abstract：:Recent advances in immunohistochemistry have made it possible to investigate lymphomas for the expression of a wide range of antigens in fixed tissues. Epitope retrieval, sensitive detection methods, and the availability of new monoclonal antibodies have all contributed to one's ability to perform detailed immunopheno...

journal_title：Advances in anatomic pathology

authors： Hsi ED,Yegappan S

更新日期：2001-07-01 00:00:00

abstract：:Microarrays began to be used to study gene expression profiles in the mid-1990s, but it was only after 2000 that serious attempts have been made to apply this technology to investigate sarcomas. Microarray technologies provide a comprehensive survey of active molecular pathways and potential molecular targets for diag...

journal_title：Advances in anatomic pathology

authors： Nielsen TO

更新日期：2006-07-01 00:00:00

abstract：:Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reach...

journal_title：Advances in anatomic pathology

authors： Iczkowski KA,Paner GP,Van der Kwast T

更新日期：2018-01-01 00:00:00

abstract：:Diffuse aggressive B-cell lymphomas comprise a relatively common and increasingly diverse group of neoplasms. Newer modalities including gene expression profiling and an increasing panel of immunohistochemical markers have contributed to greater accuracy in defining these entities. Attention is paid not only to the ne...

journal_title：Advances in anatomic pathology

authors： Said J

更新日期：2009-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has distinct morphologic features and can be identified in the majority of cases by routine hematoxylin and eosin (H&E)-stained formalin-fixed paraffin-embedded sections. However, distinguishing a well-differentiated HCC from normal or regenerative tissue may be very difficult in some ca...

journal_title：Advances in anatomic pathology

authors： Varma V,Cohen C

更新日期：2004-09-01 00:00:00

abstract：:Neoplasms and pseudotumors of the temporomandibular joint (TMJ) are very uncommon. Early recognition of such will prevent therapeutic delay and may have a dramatic impact on patient morbidity and mortality. Included in rare TMJ lesions are the following: 1) synovial chondromatosis, 2) osteochondroma, 3) osteoma, 4) os...

journal_title：Advances in anatomic pathology

authors： Warner BF,Luna MA,Robert Newland T

更新日期：2000-11-01 00:00:00