Diffuse aggressive B-cell lymphomas.

Abstract:

:Diffuse aggressive B-cell lymphomas comprise a relatively common and increasingly diverse group of neoplasms. Newer modalities including gene expression profiling and an increasing panel of immunohistochemical markers have contributed to greater accuracy in defining these entities. Attention is paid not only to the neoplastic cells but also to the cellular and stromal milieu in which they proliferate. These distinctions may have therapeutic implications as well, with improved outcome related to newer and sometimes targeted therapies. At the same time there is increasing understanding of the overlap, which occurs in the grey zone between diffuse large B-cell lymphoma and Burkitt lymphoma as well as between diffuse large B-cell lymphoma and Hodgkin lymphoma. This review aims to provide practical insights in the correct identification and differential diagnosis of these lymphomas, with emphasis on the changes that have occurred with the publication of the 2008 World Health Organization updated classification.

journal_name

Adv Anat Pathol

authors

Said J

doi

10.1097/PAP.0b013e3181a9d5d2

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

216-35

issue

4

eissn

1072-4109

issn

1533-4031

pii

00125480-200907000-00004

journal_volume

16

pub_type

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