Abstract:
:Thyroid microcarcinoma, defined as a thyroid tumor measuring 1 cm or less, is an extremely indolent tumor. Papillary microcarcinoma, the most common subtype, is often identified incidentally in a thyroid removed for benign clinical nodules or diffuse processes (eg, thyroiditis). In this clinical situation, over 99% are cured by simple lobectomy. In the less common scenario, the microcarcinoma is the primary lesion to a lymph node metastasis presenting clinically as a neck mass; in this situation, the tumor should be treated as a clinical cancer. Other rare microcarcinomas can occur and, of these, the most recently described is micromedullary carcinoma. In the familial setting, these lesions are identified in prophylactic thyroidectomies and are not unexpected findings. However, when found as sporadic tumors, their implications are still unknown. The histologic features, pathologic mimics, and molecular facets of these microscopic neoplasms are discussed in this review.
journal_name
Adv Anat Patholjournal_title
Advances in anatomic pathologyauthors
Baloch ZW,LiVolsi VAdoi
10.1097/01.pap.0000213006.10362.17subject
Has Abstractpub_date
2006-03-01 00:00:00pages
69-75issue
2eissn
1072-4109issn
1533-4031pii
00125480-200603000-00001journal_volume
13pub_type
杂志文章,评审abstract::Papillary renal cell carcinoma is the second most common malignant renal epithelial tumor and constitutes approximately 15% of renal cell tumors. However, papillary architecture is neither unique to papillary renal cell carcinoma, nor do all papillary renal cell carcinomas show exclusive papillary histology. Many of t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31820cb3dd
更新日期:2011-03-01 00:00:00
abstract::Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000288
更新日期:2021-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) has distinct morphologic features and can be identified in the majority of cases by routine hematoxylin and eosin (H&E)-stained formalin-fixed paraffin-embedded sections. However, distinguishing a well-differentiated HCC from normal or regenerative tissue may be very difficult in some ca...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000131822.31576.9d
更新日期:2004-09-01 00:00:00
abstract::CD 117 (KIT) is a transmembrane, tyrosine kinase growth factor receptor which is expressed on numerous diverse fetal and adult cells including hematopoietic cells, mast cells, melanocytes, germ cells, and the interstitial cells of Cajal. Its expression in tumors is also diverse, but with selective use and attention to...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200201000-00007
更新日期:2002-01-01 00:00:00
abstract::Epithelioid hemangioendothelioma is a vascular tumor of low to intermediate malignancy that was initially described in the soft tissue. Since then, epithelioid hemangioendothelioma has been described in various anatomic sites including parenchymal tissues and the bone. In the bone, these tumors must not only be distin...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000027
更新日期:2014-07-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is a broad term that includes liver diseases characterized by abnormal hepatocellular accumulations of lipid that cannot be related to alcohol abuse. It may be found in both adults and children, particularly those who are obese or have insulin resistance. Steatohepatitis is a ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318220f59b
更新日期:2011-07-01 00:00:00
abstract::The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000163
更新日期:2017-09-01 00:00:00
abstract::Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reach...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000168
更新日期:2018-01-01 00:00:00
abstract::Dysproteinemia is a clinical state characterized by abnormal, often excessive, synthesis of immunoglobulin (Ig) molecules or subunits. Dysproteinemia results from clonal proliferation of plasma cells or B lymphocytes. The abnormal circulating Ig molecules or subunits (most commonly free light chains) reach the glomeru...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200401000-00005
更新日期:2004-01-01 00:00:00
abstract::Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are oc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318234ab36
更新日期:2012-01-01 00:00:00
abstract::Invasive micropapillary carcinoma has been recently recognized as a rare but distinctive variant of carcinoma in various anatomic sites, including breast, urinary bladder, lung, and major salivary glands. Morphologically, it is characterized by small tight clusters of neoplastic cells floating in clear spaces resembli...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000138142.26882.fe
更新日期:2004-11-01 00:00:00
abstract::Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chr...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000291
更新日期:2021-01-04 00:00:00
abstract::Tissue microarrays (TMAs) provide unique resources for rapid evaluation and validation of tissue biomarkers. The Canary Foundation Retrospective Prostate Tissue Microarray Resource used a rigorous statistical design, quota sampling, a variation of the case-cohort study, to select patients for inclusion in a multicente...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31827b665b
更新日期:2013-01-01 00:00:00
abstract::Pheochromocytomas are uncommon neuroendocrine tumors arising in the adrenal medulla, whereas paragangliomas arise from chromaffin cells in sympathetic and parasympathetic locations outside of the adrenal gland. Molecular genetic studies in the past few years have identified >10 genes involved in the pathogenesis of ph...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000086
更新日期:2015-09-01 00:00:00
abstract::We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000068
更新日期:2015-05-01 00:00:00
abstract::Pancreatic cancer is an aggressive disease with a dismal prognosis in dire need of novel diagnostic and therapeutic approaches. The past decade has witnessed an explosion of data on the genetic alterations that occur in pancreatic cancer, as comprehensive next-generation sequencing analyses have been performed on samp...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000172
更新日期:2018-03-01 00:00:00
abstract::Fluorescence in-situ hybridization (FISH) has arisen as a novel ancillary test for the pathological diagnosis of melanoma. It is an outgrowth of studies using comparative genomic hybridization, a technique capable of surveying the entire genome for DNA copy number changes. An original report published in 2009 showed h...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182169b69
更新日期:2011-05-01 00:00:00
abstract::The analysis of a large number of tumor tissues with conventional techniques of molecular pathology is tedious and slow. The authors recently developed the tissue microarray technology that makes it possible to sample up to 1,000 tumors on one glass slide, which then can be analyzed by fluorescence in situ hybridizati...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-200101000-00002
更新日期:2001-01-01 00:00:00
abstract::The development of small-molecule inhibitors of the epidermal growth factor receptor (EGFR) resulted in new therapeutic options for patients with advanced lung cancer. It was clear from the experience with targeted therapy for breast cancer that a new standardized assay procedure for assessing and predicting the effec...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31817bf5a9
更新日期:2008-07-01 00:00:00
abstract::Approximately 25% of patients with stage I (node negative) breast cancer relapse at a rate similar to those with stage II disease. Inadvertent pathologic "understaging" of lymph node status is one plausible explanation for this phenomenon. While many studies have shown that additional sectioning +/- immunohistochemica...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-200007030-00003
更新日期:2000-05-01 00:00:00
abstract::In this review, a recently published pattern-based risk stratification system of endocervical adenocarcinoma (EAC) is presented. This novel system evaluates the morphologic features of the tumor and establishes patterns that are associated with a particular tumor behavior. Patients with pattern A EAC do not develop ly...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000097
更新日期:2015-11-01 00:00:00
abstract::This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31819923e4
更新日期:2009-03-01 00:00:00
abstract::This article reviews the recent dermatopathology literature regarding cutaneous adnexal neoplasms, with emphasis on new and underrecognized entities, "old entities" with new findings, advances in immunohistochemistry, and new findings in relation to inherited disorders associated with cutaneous adnexal neoplasms. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182a28a3f
更新日期:2013-09-01 00:00:00
abstract::Anal squamous cell carcinoma and its precursor lesions are increasing in incidence in the United States and Europe. This trend predates human immunodeficiency virus/acquired immune deficiency syndrome and has been associated with persistent high-risk human papilloma virus (HPV) genotype infection, previous lower genit...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318183234b
更新日期:2008-09-01 00:00:00
abstract::For many pathologists, the roles of the medical director are not clearly distinguished from other medical leadership and management duties, such as those of the chair of pathology or a section head of anatomic pathology. We describe the evolution in the understanding of the roles of the medical director as defined by ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182026c0b
更新日期:2011-01-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181594720
更新日期:2008-01-01 00:00:00
abstract::Central nervous system (CNS) neoplasms can be diagnostically challenging, due to remarkably wide ranges in histologic appearance, biologic behavior, and therapeutic approach. Nevertheless, accurate diagnosis is the critical first step in providing optimal patient care. As with other oncology-based specialties, there i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000175117.47918.f7
更新日期:2005-07-01 00:00:00
abstract::Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine an...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181d97836
更新日期:2010-05-01 00:00:00
abstract::Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of n...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000003
更新日期:2014-01-01 00:00:00
abstract::The diagnosis of minimal prostatic adenocarcinoma can be challenging on prostate needle biopsy, and immunohistochemistry may be used to support the diagnosis of cancer. The International Society of Urologic Pathology currently recommends the use of the basal cell markers high-molecular-weight cytokeraratin and p63, an...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000136
更新日期:2017-01-01 00:00:00