Abstract:
:Papillary renal cell carcinoma is the second most common malignant renal epithelial tumor and constitutes approximately 15% of renal cell tumors. However, papillary architecture is neither unique to papillary renal cell carcinoma, nor do all papillary renal cell carcinomas show exclusive papillary histology. Many of the nonpapillary renal cell carcinomas with papillary architecture have been recognized only recently. Distinction of these from papillary renal cell carcinoma is essential, as biologic behavior and potential therapeutic options are distinct in many such tumors. Close attention to the cytologic and growth pattern characteristics will allow us to arrive at the proper diagnosis in most cases, although sometimes immunohistochemistry and rarely genetic evaluation may be needed.
journal_name
Adv Anat Patholjournal_title
Advances in anatomic pathologyauthors
Tickoo SK,Reuter VEdoi
10.1097/PAP.0b013e31820cb3ddsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
120-32issue
2eissn
1072-4109issn
1533-4031pii
00125480-201103000-00002journal_volume
18pub_type
杂志文章,评审abstract::This article reviews the recent dermatopathology literature regarding cutaneous adnexal neoplasms, with emphasis on new and underrecognized entities, "old entities" with new findings, advances in immunohistochemistry, and new findings in relation to inherited disorders associated with cutaneous adnexal neoplasms. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182a28a3f
更新日期:2013-09-01 00:00:00
abstract::Digital imaging has progressed at a rapid rate and is likely to eventually replace chemical photography in most areas of professional and amateur digital image acquisition. In pathology, digital microscopy has implications beyond that of taking a photograph. The arguments for adopting this new medium are compelling, a...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200303000-00003
更新日期:2003-03-01 00:00:00
abstract::We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000068
更新日期:2015-05-01 00:00:00
abstract::Gastrointestinal (GI) tract tumors with melanocytic differentiation may present significant diagnostic challenges both for the pathologist and the clinician. This comprehensive review discusses the relatively common as well as rare entities that have melanocytic differentiation in the GI tract. Clinical, histologic, i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182a92e42
更新日期:2013-11-01 00:00:00
abstract::Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathol...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318155709a
更新日期:2007-11-01 00:00:00
abstract::The estrogen receptor (ER) is a regulator of cellular growth, proliferation, and differentiation. In addition to having prognostic value, ER is the most important biologic marker of therapeutic response in breast cancer. Some level of measurable ER protein is expressed in 70-80% of human breast. Immunohistochemistry i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200501000-00003
更新日期:2005-01-01 00:00:00
abstract::Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondro...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181b506a1
更新日期:2009-09-01 00:00:00
abstract::Tissue microarrays (TMAs) provide unique resources for rapid evaluation and validation of tissue biomarkers. The Canary Foundation Retrospective Prostate Tissue Microarray Resource used a rigorous statistical design, quota sampling, a variation of the case-cohort study, to select patients for inclusion in a multicente...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31827b665b
更新日期:2013-01-01 00:00:00
abstract::In this review, a recently published pattern-based risk stratification system of endocervical adenocarcinoma (EAC) is presented. This novel system evaluates the morphologic features of the tumor and establishes patterns that are associated with a particular tumor behavior. Patients with pattern A EAC do not develop ly...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000097
更新日期:2015-11-01 00:00:00
abstract::Inflammatory skin diseases encompass a vast array of conditions. The field continues to expand and evolve with resurgence of conditions, through newly recognized medication adverse effects, and via more detailed descriptions of known dermatoses. The importance of clinicopathologic correlation and an up to date knowled...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000210
更新日期:2019-01-01 00:00:00
abstract::Approximately 25% of patients with stage I (node negative) breast cancer relapse at a rate similar to those with stage II disease. Inadvertent pathologic "understaging" of lymph node status is one plausible explanation for this phenomenon. While many studies have shown that additional sectioning +/- immunohistochemica...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-200007030-00003
更新日期:2000-05-01 00:00:00
abstract::IMP3 is a member of a family of RNA-binding proteins that consists of IMP1, IMP2 and IMP3. These proteins contain 2 RNA recognition motifs and 4 K-homology domains that allow them to bind RNAs strongly and specifically. IMP3 is an oncofetal protein involved in embryogenesis and its expression is associated with a numb...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000021
更新日期:2014-05-01 00:00:00
abstract::Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic but several non-neoplastic conditions are also composed of spindle cells. This review discusses the main differential diagnoses of an ovarian spindle cell lesion, especially concentrating on the recent literature. The majorit...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3180ca8a5b
更新日期:2007-09-01 00:00:00
abstract::Human epidermal growth factor receptor 2 (HER-2) is over-expressed in 15% to 30% of breast cancers and is a poor prognostic marker in node-positive patients. HER-2 expression is an indicator of greater sensitivity to anthracycline-based chemotherapy and is the major criterion for selection for treatment with the anti-...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000213043.16200.92
更新日期:2006-09-01 00:00:00
abstract::Follicular dendritic cell sarcoma (FDCS) is an intermediate-grade malignancy of follicular dendritic cells, which are derived from mesenchymal stem cells. Nodal FDCS is well-recognized. However, when it occurs at an extranodal site, it may not be recognized and is often misdiagnosed. These tumors exhibit a variable sp...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000281
更新日期:2021-01-01 00:00:00
abstract::The analysis of a large number of tumor tissues with conventional techniques of molecular pathology is tedious and slow. The authors recently developed the tissue microarray technology that makes it possible to sample up to 1,000 tumors on one glass slide, which then can be analyzed by fluorescence in situ hybridizati...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-200101000-00002
更新日期:2001-01-01 00:00:00
abstract::Nephropathology is a specialized field requiring routine tissue evaluation by immunofluorescence (IF), electron microscopy (EM), and light microscopy, and has published standards of best practice. Actual practices are less well documented. We therefore evaluated actual practices in nephropathology and their divergence...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0b013e31803250d8
更新日期:2007-03-01 00:00:00
abstract::The topic of hereditary gynecologic malignancies readily evokes associations between Lynch syndrome and endometrial adenocarcinoma, or between BRCA mutations and tubo-ovarian serous carcinoma, but other familial associations are less well-known. Two hereditary syndromes are known to be related to uterine mesenchymal t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000175
更新日期:2018-03-01 00:00:00
abstract::Collecting duct carcinoma (CDC) and related tumors [ie, renal medullary carcinoma (RMC)] are rare types of highly aggressive renal cell carcinomas (RCC) with poor prognosis. Because of the rarity and diagnostic uncertainty of them, their molecular pathology and significance have not yet been fully elucidated. CDC, RMC...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000138
更新日期:2017-03-01 00:00:00
abstract::Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of n...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000003
更新日期:2014-01-01 00:00:00
abstract::Descriptions of poorly differentiated thyroid carcinomas, tumors with outcomes midway between that associated with well-differentiated and anaplastic carcinomas, have been prominent in the literature of the recent past. The neoplasms are characterized by the finding of poorly differentiated areas within papillary and ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-199909000-00004
更新日期:1999-09-01 00:00:00
abstract::Intraoperative consultation remains an invaluable tool in the initial evaluation of surgically excised specimens. Good communication is required between the pathologist and surgeon to obtain the best care for their mutual patient. Intraoperative consultation (frozen section, FS) provides a preliminary diagnosis for th...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0b013e3182169934
更新日期:2011-11-01 00:00:00
abstract::This manuscript presents a review of infectious causes of gastritis aimed at the practicing anatomic pathologist. We shall highlight unique histologic findings and clinical attributes that will assist those analyzing endoscopically obtained mucosal biopsies of the stomach or resection specimens. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000187
更新日期:2018-07-01 00:00:00
abstract::This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31819923e4
更新日期:2009-03-01 00:00:00
abstract::In recent years there have been a plethora of publications regarding the value of immunohistochemical studies in diagnosis in gynecological pathology. In many instances, papers are published initially that suggest that a certain antibody or panel of antibodies is of value in the diagnosis of a particular neoplasm and ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200405000-00004
更新日期:2004-05-01 00:00:00
abstract::Ocular adnexal lymphomas comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of extranodal lymphomas. They are a heterogeneous group of malignancies, the majority of which are primary extranodal lymphoma with most (up to 80%) of the marginal zone of mucosa associated lymphoid tissue type (MALT lymphoma). This ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181e4abdb
更新日期:2010-07-01 00:00:00
abstract::Digital pathology systems offer pathologists an alternate, emerging mechanism to manage and interpret information. They offer increasingly fast and scalable hardware platforms for slide scanning and software that facilitates remote viewing, slide conferencing, archiving, and image analysis. Deployed initially and vali...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318253459e
更新日期:2012-05-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a systemic, progressive, and fatal condition affecting almost exclusively women in their reproductive years. LAM most often occurs as a sporadic disease, but also occurs in women with tuberous sclerosis complex (TSC) (syndromic LAM). There are no pathologic differences between sporadi...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0b013e3181f896dc
更新日期:2010-11-01 00:00:00
abstract::The concept of Waldenstrom macroglobulinemia has evolved from the original description of a clinical syndrome to its more recent designation as a distinct clinicopathologic entity, that is, lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM), in the World Health Organization (WHO) classification and by t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000184176.65919.17
更新日期:2005-09-01 00:00:00
abstract::Microarrays began to be used to study gene expression profiles in the mid-1990s, but it was only after 2000 that serious attempts have been made to apply this technology to investigate sarcomas. Microarray technologies provide a comprehensive survey of active molecular pathways and potential molecular targets for diag...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200607000-00003
更新日期:2006-07-01 00:00:00