Abstract:
:Microarrays began to be used to study gene expression profiles in the mid-1990s, but it was only after 2000 that serious attempts have been made to apply this technology to investigate sarcomas. Microarray technologies provide a comprehensive survey of active molecular pathways and potential molecular targets for diagnosis and treatment, but are challenging to use because of issues of specimen collection, cost, and complexities in experimental design and data analysis. As a discovery-based technique, microarray analyses are most valuable when framed around specific gaps in our knowledge of tumor etiology and progression, challenges in differential diagnosis, and pressing therapeutic needs. To date, microarray analyses of sarcomas support their division into molecularly defined and molecularly heterogeneous categories, and have provided useful diagnostic markers for entities such as gastrointestinal stromal tumors, synovial sarcoma, and dermatofibrosarcoma protuberans. Signatures predicting outcome and response to therapy have been published for Ewing sarcoma and osteosarcoma, and receptor tyrosine kinase expression patterns have suggested novel therapeutic approaches which may be applied to several types of sarcoma. Nevertheless, results need to be interpreted in the context of histopathology and validated by complementary technologies and/or other research groups.
journal_name
Adv Anat Patholjournal_title
Advances in anatomic pathologyauthors
Nielsen TOdoi
10.1097/00125480-200607000-00003subject
Has Abstractpub_date
2006-07-01 00:00:00pages
166-73issue
4eissn
1072-4109issn
1533-4031pii
00125480-200607000-00003journal_volume
13pub_type
杂志文章,评审abstract::Descriptions of poorly differentiated thyroid carcinomas, tumors with outcomes midway between that associated with well-differentiated and anaplastic carcinomas, have been prominent in the literature of the recent past. The neoplasms are characterized by the finding of poorly differentiated areas within papillary and ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-199909000-00004
更新日期:1999-09-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a systemic, progressive, and fatal condition affecting almost exclusively women in their reproductive years. LAM most often occurs as a sporadic disease, but also occurs in women with tuberous sclerosis complex (TSC) (syndromic LAM). There are no pathologic differences between sporadi...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0b013e3181f896dc
更新日期:2010-11-01 00:00:00
abstract::Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine an...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181d97836
更新日期:2010-05-01 00:00:00
abstract::Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are oc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318234ab36
更新日期:2012-01-01 00:00:00
abstract::Plasmacytoid dendritic cells (PDCs) have perplexed pathologists for decades, undergoing multiple adjustments in nomenclature as their lineage and functions have been characterized. Although PDCs account for less than 0.1% of peripheral blood mononuclear cells, they serve as a principal source of interferon-alpha and a...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181bb6bc2
更新日期:2009-11-01 00:00:00
abstract::Papillary renal cell carcinoma is the second most common malignant renal epithelial tumor and constitutes approximately 15% of renal cell tumors. However, papillary architecture is neither unique to papillary renal cell carcinoma, nor do all papillary renal cell carcinomas show exclusive papillary histology. Many of t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31820cb3dd
更新日期:2011-03-01 00:00:00
abstract::Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000288
更新日期:2021-01-01 00:00:00
abstract::Gliomas are a large and diverse group of primary brain tumors that include those that are diffusely infiltrative and others that are well-circumscribed and low grade. Diffuse gliomas are currently classified by the World Health Organization as astrocytomas, oligodendrogliomas, or oligoastrocytomas and range in grade f...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000048
更新日期:2015-01-01 00:00:00
abstract::The main purpose of urine cytology is to detect high-grade urothelial carcinoma. With this principle in mind, The Paris System (TPS) Working Group, composed of cytopathologists, surgical pathologists, and urologists, has proposed and published a standardized reporting system that includes specific diagnostic categorie...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000118
更新日期:2016-07-01 00:00:00
abstract::In recent years there have been a plethora of publications regarding the value of immunohistochemical studies in diagnosis in gynecological pathology. In many instances, papers are published initially that suggest that a certain antibody or panel of antibodies is of value in the diagnosis of a particular neoplasm and ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200405000-00004
更新日期:2004-05-01 00:00:00
abstract::Fluorescence in-situ hybridization (FISH) has arisen as a novel ancillary test for the pathological diagnosis of melanoma. It is an outgrowth of studies using comparative genomic hybridization, a technique capable of surveying the entire genome for DNA copy number changes. An original report published in 2009 showed h...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182169b69
更新日期:2011-05-01 00:00:00
abstract::Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic but several non-neoplastic conditions are also composed of spindle cells. This review discusses the main differential diagnoses of an ovarian spindle cell lesion, especially concentrating on the recent literature. The majorit...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3180ca8a5b
更新日期:2007-09-01 00:00:00
abstract::This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31819923e4
更新日期:2009-03-01 00:00:00
abstract::Intrahepatic ductular reaction is a pathologic proliferation of phenotypical biliary channels. Ductular reactions aim to restore compromised physiological function after liver injury and are one of the archetypal responses of the liver to a wide variety of etiologies, among them are parenchymal loss, biliary tract dis...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000294
更新日期:2021-01-19 00:00:00
abstract::We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000068
更新日期:2015-05-01 00:00:00
abstract::Inflammatory skin diseases encompass a vast array of conditions. The field continues to expand and evolve with resurgence of conditions, through newly recognized medication adverse effects, and via more detailed descriptions of known dermatoses. The importance of clinicopathologic correlation and an up to date knowled...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000210
更新日期:2019-01-01 00:00:00
abstract::Ocular adnexal lymphomas comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of extranodal lymphomas. They are a heterogeneous group of malignancies, the majority of which are primary extranodal lymphoma with most (up to 80%) of the marginal zone of mucosa associated lymphoid tissue type (MALT lymphoma). This ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181e4abdb
更新日期:2010-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) has distinct morphologic features and can be identified in the majority of cases by routine hematoxylin and eosin (H&E)-stained formalin-fixed paraffin-embedded sections. However, distinguishing a well-differentiated HCC from normal or regenerative tissue may be very difficult in some ca...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000131822.31576.9d
更新日期:2004-09-01 00:00:00
abstract::Gastric-type endocervical adenocarcinoma (GAS) is a recently described diagnostic entity originally characterized as a tumor with (1) voluminous cytoplasm that is (2) clear or pale eosinophilic, and (3) cells showing distinct cell borders. Since the initial tumor description there has been accumulating experience that...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000216
更新日期:2019-01-01 00:00:00
abstract::As genomic characterization becomes increasingly necessary for accurate diagnosis of tumors of the central nervous system, identification of rapidly assessible biomarkers is equally important to avoid excessive cost and delay in initiation of therapy. This article reviews novel immunohistochemical markers that may be ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000225
更新日期:2020-05-01 00:00:00
abstract::Evaluation of the endometrial biopsy is a challenge to practicing pathologists, largely due to the wide range of morphologic patterns resulting from both normal and abnormal cyclic changes, exogenous hormones, infections, and intrauterine tumors. Successfully addressing these challenges requires that the practitioner ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200311000-00001
更新日期:2003-11-01 00:00:00
abstract::Recent advances in immunohistochemistry have made it possible to investigate lymphomas for the expression of a wide range of antigens in fixed tissues. Epitope retrieval, sensitive detection methods, and the availability of new monoclonal antibodies have all contributed to one's ability to perform detailed immunopheno...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200107000-00003
更新日期:2001-07-01 00:00:00
abstract::Digital pathology systems offer pathologists an alternate, emerging mechanism to manage and interpret information. They offer increasingly fast and scalable hardware platforms for slide scanning and software that facilitates remote viewing, slide conferencing, archiving, and image analysis. Deployed initially and vali...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318253459e
更新日期:2012-05-01 00:00:00
abstract::The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000163
更新日期:2017-09-01 00:00:00
abstract::A variety of arthropods, protozoa, and helminths infect the skin and subcutaneous tissues and may be identified by anatomic pathologists in standard cytology and histology preparations. The specific organisms seen vary greatly with the patient's exposure history, including travel to or residence in endemic countries. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000183
更新日期:2018-03-01 00:00:00
abstract::CD 117 (KIT) is a transmembrane, tyrosine kinase growth factor receptor which is expressed on numerous diverse fetal and adult cells including hematopoietic cells, mast cells, melanocytes, germ cells, and the interstitial cells of Cajal. Its expression in tumors is also diverse, but with selective use and attention to...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200201000-00007
更新日期:2002-01-01 00:00:00
abstract::The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000147
更新日期:2017-05-01 00:00:00
abstract::Thyroid microcarcinoma, defined as a thyroid tumor measuring 1 cm or less, is an extremely indolent tumor. Papillary microcarcinoma, the most common subtype, is often identified incidentally in a thyroid removed for benign clinical nodules or diffuse processes (eg, thyroiditis). In this clinical situation, over 99% ar...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000213006.10362.17
更新日期:2006-03-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is a broad term that includes liver diseases characterized by abnormal hepatocellular accumulations of lipid that cannot be related to alcohol abuse. It may be found in both adults and children, particularly those who are obese or have insulin resistance. Steatohepatitis is a ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318220f59b
更新日期:2011-07-01 00:00:00
abstract::Gastrointestinal (GI) tract tumors with melanocytic differentiation may present significant diagnostic challenges both for the pathologist and the clinician. This comprehensive review discusses the relatively common as well as rare entities that have melanocytic differentiation in the GI tract. Clinical, histologic, i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3182a92e42
更新日期:2013-11-01 00:00:00