Lymphoma immunophenotyping: a new era in paraffin-section immunohistochemistry.

abstract：:The estrogen receptor (ER) is a regulator of cellular growth, proliferation, and differentiation. In addition to having prognostic value, ER is the most important biologic marker of therapeutic response in breast cancer. Some level of measurable ER protein is expressed in 70-80% of human breast. Immunohistochemistry i...

journal_title：Advances in anatomic pathology

authors： Diaz LK,Sneige N

更新日期：2005-01-01 00:00:00

abstract：:IMP3 is a member of a family of RNA-binding proteins that consists of IMP1, IMP2 and IMP3. These proteins contain 2 RNA recognition motifs and 4 K-homology domains that allow them to bind RNAs strongly and specifically. IMP3 is an oncofetal protein involved in embryogenesis and its expression is associated with a numb...

journal_title：Advances in anatomic pathology

authors： Gong Y,Woda BA,Jiang Z

更新日期：2014-05-01 00:00:00

abstract：:Evaluation of the endometrial biopsy is a challenge to practicing pathologists, largely due to the wide range of morphologic patterns resulting from both normal and abnormal cyclic changes, exogenous hormones, infections, and intrauterine tumors. Successfully addressing these challenges requires that the practitioner ...

journal_title：Advances in anatomic pathology

authors： Crum CP,Hornstein MD,Nucci MR,Mutter GL

更新日期：2003-11-01 00:00:00

abstract：:Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyc...

journal_title：Advances in anatomic pathology

authors： Arafah M,Rashid S,Akhtar M

更新日期：2021-01-01 00:00:00

abstract：:The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding ...

journal_title：Advances in anatomic pathology

authors： Basolo F,Macerola E,Ugolini C,Poller DN,Baloch Z

更新日期：2017-09-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine an...

journal_title：Advances in anatomic pathology

authors： Calder KB,Smoller BR

更新日期：2010-05-01 00:00:00

abstract：:Nephropathology is a specialized field requiring routine tissue evaluation by immunofluorescence (IF), electron microscopy (EM), and light microscopy, and has published standards of best practice. Actual practices are less well documented. We therefore evaluated actual practices in nephropathology and their divergence...

journal_title：Advances in anatomic pathology

authors： Pullman JM,Ferrario F,Nast CC

更新日期：2007-03-01 00:00:00

abstract：:Ocular adnexal lymphomas comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of extranodal lymphomas. They are a heterogeneous group of malignancies, the majority of which are primary extranodal lymphoma with most (up to 80%) of the marginal zone of mucosa associated lymphoid tissue type (MALT lymphoma). This ...

journal_title：Advances in anatomic pathology

authors： McKelvie PA

更新日期：2010-07-01 00:00:00

abstract：:Immunohistochemistry (IHC) is routinely performed in most laboratories, and other than purchase of commercially available antibodies, requires no additional equipment or reagents. As such, IHC is an accessible and relatively inexpensive test and one that can be performed quite quickly. This is in sharp contrast to gen...

journal_title：Advances in anatomic pathology

authors： Oh KS,Mahalingam M

更新日期：2019-11-01 00:00:00

abstract：:Pheochromocytomas are uncommon neuroendocrine tumors arising in the adrenal medulla, whereas paragangliomas arise from chromaffin cells in sympathetic and parasympathetic locations outside of the adrenal gland. Molecular genetic studies in the past few years have identified >10 genes involved in the pathogenesis of ph...

journal_title：Advances in anatomic pathology

authors： Guo Z,Lloyd RV

更新日期：2015-09-01 00:00:00

abstract：:Oral developmental, reactive, benign neoplastic and malignant neoplastic conditions, many odontogenic in origin, may not be seen routinely by the general surgical pathologist and therefore may present a diagnostic dilemma. This article describes odontogenic and nonodontogenic conditions with little or no destructive p...

journal_title：Advances in anatomic pathology

authors： Massey D

更新日期：2005-11-01 00:00:00

abstract：:Diffuse aggressive B-cell lymphomas comprise a relatively common and increasingly diverse group of neoplasms. Newer modalities including gene expression profiling and an increasing panel of immunohistochemical markers have contributed to greater accuracy in defining these entities. Attention is paid not only to the ne...

journal_title：Advances in anatomic pathology

authors： Said J

更新日期：2009-07-01 00:00:00

abstract：:The topic of hereditary gynecologic malignancies readily evokes associations between Lynch syndrome and endometrial adenocarcinoma, or between BRCA mutations and tubo-ovarian serous carcinoma, but other familial associations are less well-known. Two hereditary syndromes are known to be related to uterine mesenchymal t...

journal_title：Advances in anatomic pathology

authors： Joehlin-Price AS,Garg K

更新日期：2018-03-01 00:00:00

abstract：:Intrahepatic ductular reaction is a pathologic proliferation of phenotypical biliary channels. Ductular reactions aim to restore compromised physiological function after liver injury and are one of the archetypal responses of the liver to a wide variety of etiologies, among them are parenchymal loss, biliary tract dis...

journal_title：Advances in anatomic pathology

authors： Jain R,Clark I

更新日期：2021-01-19 00:00:00

abstract：:Current World Health Organization (WHO) classification of lung adenocarcinomas includes noninvasive bronchioloalveolar carcinoma (BAC) and several patterns of invasive adenocarcinoma. The most common is a mixed subtype of adenocarcinoma. This group is very heterogenous and includes a wide spectrum of tumors ranging fr...

journal_title：Advances in anatomic pathology

authors： Dacic S

更新日期：2009-05-01 00:00:00

abstract：:Atypical cribriform lesions of the prostate gland consist of cribriform and rarely solid proliferation of prostate glands populated with cytologically atypical cells with partial or complete basal cell lining. It may represent cribriform "high-grade prostatic intraepithelial neoplasia" (HGPIN) or "intraductal carcinom...

journal_title：Advances in anatomic pathology

authors： Shah RB,Zhou M

更新日期：2012-07-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a systemic, progressive, and fatal condition affecting almost exclusively women in their reproductive years. LAM most often occurs as a sporadic disease, but also occurs in women with tuberous sclerosis complex (TSC) (syndromic LAM). There are no pathologic differences between sporadi...

journal_title：Advances in anatomic pathology

authors： Bisceglia M,D'Alessandro V,Simeone A,Ben-Dor D,Pasquinelli G

更新日期：2010-11-01 00:00:00

abstract：:We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...

journal_title：Advances in anatomic pathology

authors： Galliani CA,Sanchez IC,D'Errico MM,Bisceglia M

更新日期：2015-05-01 00:00:00

abstract：:This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are disc...

journal_title：Advances in anatomic pathology

authors： Stelow EB,French CA

更新日期：2009-03-01 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is an intermediate-grade malignancy of follicular dendritic cells, which are derived from mesenchymal stem cells. Nodal FDCS is well-recognized. However, when it occurs at an extranodal site, it may not be recognized and is often misdiagnosed. These tumors exhibit a variable sp...

journal_title：Advances in anatomic pathology

authors： Kaur R,Mehta J,Borges A

更新日期：2021-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has distinct morphologic features and can be identified in the majority of cases by routine hematoxylin and eosin (H&E)-stained formalin-fixed paraffin-embedded sections. However, distinguishing a well-differentiated HCC from normal or regenerative tissue may be very difficult in some ca...

journal_title：Advances in anatomic pathology

authors： Varma V,Cohen C

更新日期：2004-09-01 00:00:00

abstract：:Anal squamous cell carcinoma and its precursor lesions are increasing in incidence in the United States and Europe. This trend predates human immunodeficiency virus/acquired immune deficiency syndrome and has been associated with persistent high-risk human papilloma virus (HPV) genotype infection, previous lower genit...

journal_title：Advances in anatomic pathology

authors： Longacre TA,Kong CS,Welton ML

更新日期：2008-09-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) and related tumors [ie, renal medullary carcinoma (RMC)] are rare types of highly aggressive renal cell carcinomas (RCC) with poor prognosis. Because of the rarity and diagnostic uncertainty of them, their molecular pathology and significance have not yet been fully elucidated. CDC, RMC...

journal_title：Advances in anatomic pathology

authors： Seo AN,Yoon G,Ro JY

更新日期：2017-03-01 00:00:00

abstract：:Thyroid microcarcinoma, defined as a thyroid tumor measuring 1 cm or less, is an extremely indolent tumor. Papillary microcarcinoma, the most common subtype, is often identified incidentally in a thyroid removed for benign clinical nodules or diffuse processes (eg, thyroiditis). In this clinical situation, over 99% ar...

journal_title：Advances in anatomic pathology

authors： Baloch ZW,LiVolsi VA

更新日期：2006-03-01 00:00:00

abstract：:Inflammatory skin diseases encompass a vast array of conditions. The field continues to expand and evolve with resurgence of conditions, through newly recognized medication adverse effects, and via more detailed descriptions of known dermatoses. The importance of clinicopathologic correlation and an up to date knowled...

journal_title：Advances in anatomic pathology

authors： Penn L,Rothman L,Sutton AM,Brinster NK,Vidal CI

更新日期：2019-01-01 00:00:00

abstract：:This paper reviews the pathologic features of lesions which are oncocytic and involve classic endocrine organs. The history of the oncocytic cell, its morphologic and ultrastructural features, and important immunohistochemical findings are reviewed. Oncocytic proliferations including non-neoplastic and neoplastic of t...

journal_title：Advances in anatomic pathology

authors： Canberk S,LiVolsi VA,Baloch Z

更新日期：2014-03-01 00:00:00

abstract：:Pathology has benefited from advanced innovation with novel technology to implement a digital solution. Whole slide imaging is a disruptive technology where glass slides are scanned to produce digital images. There have been significant advances in whole slide scanning hardware and software that have allowed for ready...

journal_title：Advances in anatomic pathology

authors： Hanna MG,Parwani A,Sirintrapun SJ

更新日期：2020-07-01 00:00:00

abstract：:Inflammatory osteolysis is a relatively frequent and incapacitating complication of rheumatoid arthritis and other inflammatory diseases, and is induced by accelerated osteoclast recruitment and activation in bone under the aegis of cytokines produced in the inflammatory environment. The success of antitumor necrosis ...

journal_title：Advances in anatomic pathology

authors： Wei S,Siegal GP

更新日期：2007-01-01 00:00:00

abstract：:The development of small-molecule inhibitors of the epidermal growth factor receptor (EGFR) resulted in new therapeutic options for patients with advanced lung cancer. It was clear from the experience with targeted therapy for breast cancer that a new standardized assay procedure for assessing and predicting the effec...

journal_title：Advances in anatomic pathology

authors： Dacic S

更新日期：2008-07-01 00:00:00

abstract：:Epithelioid hemangioendothelioma is a vascular tumor of low to intermediate malignancy that was initially described in the soft tissue. Since then, epithelioid hemangioendothelioma has been described in various anatomic sites including parenchymal tissues and the bone. In the bone, these tumors must not only be distin...

journal_title：Advances in anatomic pathology

authors： Weissferdt A,Moran CA

更新日期：2014-07-01 00:00:00