Abstract:
:For many pathologists, the roles of the medical director are not clearly distinguished from other medical leadership and management duties, such as those of the chair of pathology or a section head of anatomic pathology. We describe the evolution in the understanding of the roles of the medical director as defined by the Clinical Laboratory Improvement Amendments of 1988 and separate from the roles of the chair of pathology, department chair, division chair, and a section head in anatomic pathology in our institution. Delineation of the roles of medical director, department chair, chair of anatomic pathology division, and a section head of a subdivision in anatomic pathology has helped us to understand the roles and ensure that all duties are fulfilled for patient care and for compliance and regulation.
journal_name
Adv Anat Patholjournal_title
Advances in anatomic pathologyauthors
Hernandez JSdoi
10.1097/PAP.0b013e3182026c0bsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
75-8issue
1eissn
1072-4109issn
1533-4031pii
00125480-201101000-00006journal_volume
18pub_type
杂志文章,评审abstract::Central nervous system (CNS) neoplasms can be diagnostically challenging, due to remarkably wide ranges in histologic appearance, biologic behavior, and therapeutic approach. Nevertheless, accurate diagnosis is the critical first step in providing optimal patient care. As with other oncology-based specialties, there i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000175117.47918.f7
更新日期:2005-07-01 00:00:00
abstract::Current World Health Organization (WHO) classification of lung adenocarcinomas includes noninvasive bronchioloalveolar carcinoma (BAC) and several patterns of invasive adenocarcinoma. The most common is a mixed subtype of adenocarcinoma. This group is very heterogenous and includes a wide spectrum of tumors ranging fr...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181a19e3b
更新日期:2009-05-01 00:00:00
abstract::The estrogen receptor (ER) is a regulator of cellular growth, proliferation, and differentiation. In addition to having prognostic value, ER is the most important biologic marker of therapeutic response in breast cancer. Some level of measurable ER protein is expressed in 70-80% of human breast. Immunohistochemistry i...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200501000-00003
更新日期:2005-01-01 00:00:00
abstract::Dysproteinemia is a clinical state characterized by abnormal, often excessive, synthesis of immunoglobulin (Ig) molecules or subunits. Dysproteinemia results from clonal proliferation of plasma cells or B lymphocytes. The abnormal circulating Ig molecules or subunits (most commonly free light chains) reach the glomeru...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200401000-00005
更新日期:2004-01-01 00:00:00
abstract::Invasive micropapillary carcinoma has been recently recognized as a rare but distinctive variant of carcinoma in various anatomic sites, including breast, urinary bladder, lung, and major salivary glands. Morphologically, it is characterized by small tight clusters of neoplastic cells floating in clear spaces resembli...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/01.pap.0000138142.26882.fe
更新日期:2004-11-01 00:00:00
abstract::Approximately 25% of patients with stage I (node negative) breast cancer relapse at a rate similar to those with stage II disease. Inadvertent pathologic "understaging" of lymph node status is one plausible explanation for this phenomenon. While many studies have shown that additional sectioning +/- immunohistochemica...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-200007030-00003
更新日期:2000-05-01 00:00:00
abstract::The common sources of ionizing radiation exposure to the thyroid gland in humans are accidental environmental exposure and medical, therapeutic, or diagnostic irradiation. Radiation often induces notable histologic changes in the thyroid tissue and is a well-established risk factor for benign and malignant thyroid tum...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-199903000-00002
更新日期:1999-03-01 00:00:00
abstract::Desmoplastic melanoma (DM) is a relatively rare cytomorphologic variant of melanoma with a marked propensity for perineural invasion (PNI). Historically, DMs that display PNI have been grouped under the umbrella term of neurotropic melanoma (NM). However, definitions for NM and desmoplastic NM are not consistent in th...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000076
更新日期:2015-07-01 00:00:00
abstract::Alveolar soft-part sarcoma (ASPS) is one of the most unusual of the soft tissue sarcomas. Although it most commonly arises in the fascial planes or skeletal muscles of the lower extremities in adults, and in the head and neck region in children, it has also been documented in extraskeletal muscle locations, especially...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-199905000-00001
更新日期:1999-05-01 00:00:00
abstract::Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are oc...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318234ab36
更新日期:2012-01-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is a broad term that includes liver diseases characterized by abnormal hepatocellular accumulations of lipid that cannot be related to alcohol abuse. It may be found in both adults and children, particularly those who are obese or have insulin resistance. Steatohepatitis is a ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e318220f59b
更新日期:2011-07-01 00:00:00
abstract::This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly dif...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000201
更新日期:2019-01-01 00:00:00
abstract::Diffuse aggressive B-cell lymphomas comprise a relatively common and increasingly diverse group of neoplasms. Newer modalities including gene expression profiling and an increasing panel of immunohistochemical markers have contributed to greater accuracy in defining these entities. Attention is paid not only to the ne...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e3181a9d5d2
更新日期:2009-07-01 00:00:00
abstract::This manuscript presents a review of infectious causes of gastritis aimed at the practicing anatomic pathologist. We shall highlight unique histologic findings and clinical attributes that will assist those analyzing endoscopically obtained mucosal biopsies of the stomach or resection specimens. ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000187
更新日期:2018-07-01 00:00:00
abstract::Papillary renal cell carcinoma is the second most common malignant renal epithelial tumor and constitutes approximately 15% of renal cell tumors. However, papillary architecture is neither unique to papillary renal cell carcinoma, nor do all papillary renal cell carcinomas show exclusive papillary histology. Many of t...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31820cb3dd
更新日期:2011-03-01 00:00:00
abstract::Evaluation of the endometrial biopsy is a challenge to practicing pathologists, largely due to the wide range of morphologic patterns resulting from both normal and abnormal cyclic changes, exogenous hormones, infections, and intrauterine tumors. Successfully addressing these challenges requires that the practitioner ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200311000-00001
更新日期:2003-11-01 00:00:00
abstract::Gastric-type endocervical adenocarcinoma (GAS) is a recently described diagnostic entity originally characterized as a tumor with (1) voluminous cytoplasm that is (2) clear or pale eosinophilic, and (3) cells showing distinct cell borders. Since the initial tumor description there has been accumulating experience that...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000216
更新日期:2019-01-01 00:00:00
abstract::Pathology has benefited from advanced innovation with novel technology to implement a digital solution. Whole slide imaging is a disruptive technology where glass slides are scanned to produce digital images. There have been significant advances in whole slide scanning hardware and software that have allowed for ready...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000273
更新日期:2020-07-01 00:00:00
abstract::Atypical cribriform lesions of the prostate gland consist of cribriform and rarely solid proliferation of prostate glands populated with cytologically atypical cells with partial or complete basal cell lining. It may represent cribriform "high-grade prostatic intraepithelial neoplasia" (HGPIN) or "intraductal carcinom...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31825c6c0e
更新日期:2012-07-01 00:00:00
abstract::Intrahepatic ductular reaction is a pathologic proliferation of phenotypical biliary channels. Ductular reactions aim to restore compromised physiological function after liver injury and are one of the archetypal responses of the liver to a wide variety of etiologies, among them are parenchymal loss, biliary tract dis...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000294
更新日期:2021-01-19 00:00:00
abstract::Leukoplakia as a medical term has been encumbered by a hodgepodge of synonyms and interpretations. It also has been a term associated with strong emotions with respect to an implied malignant potential. It now is regarded as potentially malignant, with varying degrees of risk for transformation. Leukoplakia at its maj...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract::Descriptions of poorly differentiated thyroid carcinomas, tumors with outcomes midway between that associated with well-differentiated and anaplastic carcinomas, have been prominent in the literature of the recent past. The neoplasms are characterized by the finding of poorly differentiated areas within papillary and ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/00125480-199909000-00004
更新日期:1999-09-01 00:00:00
abstract::Inflammatory osteolysis is a relatively frequent and incapacitating complication of rheumatoid arthritis and other inflammatory diseases, and is induced by accelerated osteoclast recruitment and activation in bone under the aegis of cytokines produced in the inflammatory environment. The success of antitumor necrosis ...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31802ef4f2
更新日期:2007-01-01 00:00:00
abstract::Epithelioid hemangioendothelioma is a vascular tumor of low to intermediate malignancy that was initially described in the soft tissue. Since then, epithelioid hemangioendothelioma has been described in various anatomic sites including parenchymal tissues and the bone. In the bone, these tumors must not only be distin...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000027
更新日期:2014-07-01 00:00:00
abstract::Endometrial endometrioid adenocarcinoma (EEC) is the most common malignancy of the female genital tract, partly attributable to chronic estrogen exposure secondary to increased obesity rates. Tumor stage, which in most cases is based on depth of invasion (DOI), is of critical importance in determining if additional tr...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0b013e31828d17cc
更新日期:2013-05-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a systemic, progressive, and fatal condition affecting almost exclusively women in their reproductive years. LAM most often occurs as a sporadic disease, but also occurs in women with tuberous sclerosis complex (TSC) (syndromic LAM). There are no pathologic differences between sporadi...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0b013e3181f896dc
更新日期:2010-11-01 00:00:00
abstract::Well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL) form the largest subgroup of liposarcomas, and represent a morphologic and behavioral spectrum of 1 disease entity, which arises typically in middle to late adult life, most frequently within the retroperitoneum or extremities. DDL is defined...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000101
更新日期:2016-01-01 00:00:00
abstract::Digital imaging has progressed at a rapid rate and is likely to eventually replace chemical photography in most areas of professional and amateur digital image acquisition. In pathology, digital microscopy has implications beyond that of taking a photograph. The arguments for adopting this new medium are compelling, a...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/00125480-200303000-00003
更新日期:2003-03-01 00:00:00
abstract::Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of n...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章,评审
doi:10.1097/PAP.0000000000000003
更新日期:2014-01-01 00:00:00
abstract::Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chr...
journal_title:Advances in anatomic pathology
pub_type: 杂志文章
doi:10.1097/PAP.0000000000000291
更新日期:2021-01-04 00:00:00