The serotype-specific glucose side chain of rhamnose-glucose polysaccharides is essential for adsorption of bacteriophage M102 to Streptococcus mutans.

Abstract:

:Bacteriophage M102 is a virulent siphophage that propagates in some serotype c Streptococcus mutans strains, but not in S. mutans of serotype e, f or k. The serotype of S. mutans is determined by the glucose side chain of rhamnose-glucose polysaccharide (RGP). Because the first step in the bacteriophage infection process is adsorption of the phage, it was investigated whether the serotype specificity of phage M102 was determined by adsorption. M102 adsorbed to all tested serotype c strains, but not to strains of different serotypes. Streptococcus mutans serotype c mutants defective in the synthesis of the glucose side chain of RGP failed to adsorb phage M102. These results suggest that the glucose side chain of RGP acts as a receptor for phage M102.

journal_name

FEMS Microbiol Lett

authors

Shibata Y,Yamashita Y,van der Ploeg JR

doi

10.1111/j.1574-6968.2009.01546.x

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

68-73

issue

1

eissn

0378-1097

issn

1574-6968

pii

FML1546

journal_volume

294

pub_type

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