Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators.


:Efficient type-III secretion depends on cytosolic molecular chaperones, which bind specifically to the translocators and effectors. In the past there has been a tendency to shoe-horn all type-III-secretion chaperones into a single structural and functional class. However, we have shown that the LcrH/SycD-like chaperones consist of three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array that is quite distinct from the known structure of the SycE class of chaperones. Furthermore, we predict that this array creates a peptide-binding groove that is utterly different from the helix-binding groove in SycE. We present a homology model of LcrH/SycD that is consistent with existing mutagenesis data. We also report the existence of tetratricopeptide-like repeats in regulators of type-III secretion, such as HilA from Salmonella enterica and HrpB from Ralstonia solanacearum. The discovery of tetratricopeptide-like repeats in type-III-secretion regulators and chaperones provides a new conceptual framework for structural and mutagenesis studies and signals a potential unification of prokaryotic and eukaryotic chaperone biology.


FEMS Microbiol Lett


Pallen MJ,Francis MS,Fütterer K





Has Abstract


2003-06-06 00:00:00














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    journal_title:FEMS microbiology letters

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    authors: Galgóczy L,Papp T,Lukács G,Leiter E,Pócsi I,Vágvölgyi C

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    journal_title:FEMS microbiology letters

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    authors: Tannaes T,Bukholm G

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    authors: Juhász A,Láday M,Gácser A,Kucsera J,Pfeiffer I,Kevei F,Hamari Z

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    pub_type: 杂志文章


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  • Synergism among volatile organic compounds resulting in increased antibiosis in Oidium sp.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


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    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Díaz-Mejía JJ,Carbajal-Saucedo A,Amábile-Cuevas CF

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    journal_title:FEMS microbiology letters

    pub_type: 信件


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    更新日期:2014-02-01 00:00:00