Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor.

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To determine whether the native basement membrane left behind after manual débridement wounding is retained throughout healing in the Balb/c mouse. METHODS:Mouse corneas were subjected to either 1.5 mm (small) or limbus-to-limbus (large) epithelial débridement wounds and allowed to heal for times ranging from ...

journal_title：Investigative ophthalmology & visual science

authors： Sta Iglesia DD,Stepp MA

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:The flavonoids have potent antioxidant and free-radical scavenging properties and are beneficial in the prevention and treatment of ocular diseases including glaucoma. The authors have previously reported that antiglaucoma agents could transcriptionally activate the antioxidant protein peroxiredoxin (PRDX)2. Th...

journal_title：Investigative ophthalmology & visual science

authors： Miyamoto N,Izumi H,Miyamoto R,Kondo H,Tawara A,Sasaguri Y,Kohno K

更新日期：2011-02-22 00:00:00

abstract：PURPOSE:To study pathologic changes in the photoreceptors in eyes with idiopathic macular telangiectasia (MacTel) type 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS:Thirteen eyes with nonproliferative MacTel type 2 and 10 normal eyes underwent a full ophthalmologic examination, spectral-domai...

journal_title：Investigative ophthalmology & visual science

authors： Ooto S,Hangai M,Takayama K,Arakawa N,Tsujikawa A,Koizumi H,Oshima S,Yoshimura N

更新日期：2011-07-25 00:00:00

abstract：PURPOSE:To examine the expression of matrix metalloproteinases (MMPs) and their inhibitors during the development of retinal neovascularization (NV) in a mouse model. METHODS:A well-characterized murine model of retinal NV was used to study the expression of specific MMPs (MMP-2, MMP-9, and MT1-MMP) and tissue inhibit...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire P,Colombo S,Das A

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To assess the effect of group B streptococcal (GBS) meningitis on retinal blood flow (RetBF) and choroidal blood flow (ChBF) autoregulation in sedated newborn piglets (1 to 5 days of age). METHODS:Fourteen study animals injected with 0.5 ml heat-killed GBS (10(9)) were compared to 10 control animals injected w...

journal_title：Investigative ophthalmology & visual science

authors： Bottoli I,Beharry K,Modanlou HD,Norris K,Ling E,Noya F,Amato MM,Aranda JV

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:Mice (Pdegtm1/Pdegtm1) homozygous for a mutant allele of the gamma subunit of retinal cyclic guanosine monophosphate phosphodiesterase (PDE gamma) suffer a severe photoreceptor degeneration. To determine whether the antiapoptotic BCL2 gene is effective in delaying the cell death pathway in this new strain of mu...

journal_title：Investigative ophthalmology & visual science

authors： Tsang SH,Chen J,Kjeldbye H,Li WS,Simon MI,Gouras P,Goff SP

更新日期：1997-04-01 00:00:00

abstract：:Cellular retinol binding protein (CRBP) was localized in the rat retina by means of light and electron microscopic immunocytochemistry. The peroxidase-antiperoxidase (PAP) method employed at the light microscopic level showed that CRBP is sharply localized to the retinal pigment epithelium (RPE). None was detectable i...

journal_title：Investigative ophthalmology & visual science

authors： Bok D,Ong DE,Chytil F

更新日期：1984-08-01 00:00:00

abstract：:Sections of the ciliary epithelium of adult sharks (Squalus acanthias) were mounted in Ussing-type chambers (area 0.2 cm2) for measurements of transepithelial potential difference (PD), short circuit current (SCC) and calculation of transepithelial resistance (R). In 15 preparations PD was aqueous side negative (-0.51...

journal_title：Investigative ophthalmology & visual science

authors： Wiederholt M,Zadunaisky JA

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Recent studies on ocular shape have raised increased interest in the peripheral characteristics of the eye, as it potentially triggers changes in the central vision. Current techniques are, however, not capable of accurately measuring the three-dimensional shape of the retina. We describe a new magnetic resonan...

journal_title：Investigative ophthalmology & visual science

authors： Beenakker JW,Shamonin DP,Webb AG,Luyten GP,Stoel BC

更新日期：2015-01-15 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Contraction of fibroblasts and the resultant tractional force is a contributing factor to fibrotic diseases of the eye, such as proliferative vitreoretinopathy (PVR). Transforming growth factor (TGF)-beta is abundant in the eye, and is one of the growth factors thought to contribute to the development of PVR. A...

journal_title：Investigative ophthalmology & visual science

authors： Ikuno Y,Kazlauskas A

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The increase of nerve growth factor (NGF) plasma levels in vernal keratoconjunctivitis (VKC) patients has been demonstrated previously. Results of numerous studies in vitro and in vivo have shown that NGF modulates the synthesis of substance P (SP), a neuropeptide involved in the pathogenesis of human allergic ...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Micera A,Tirassa P,Magrini L,Bonini S,Aloe L

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:Müller glia have multiple functions in the retina, including synthesis of neurotrophic factors, uptake and metabolism of neurotransmitters, spatial buffering of ions, maintenance of the blood-retinal barrier, and response to injury. A population of Müller glia has some stem cell-like characteristics both in viv...

journal_title：Investigative ophthalmology & visual science

authors： Otteson DC,Phillips MJ

更新日期：2010-11-01 00:00:00

abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

journal_title：Investigative ophthalmology & visual science

authors： Soong H,Fischbarg J,Iwamoto T

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes. METHODS:Control and streptozotocin (STZ)-diabetic rats were treated with or without the PARP inhibitors 1,5-isoquinolinediol (ISO; 3 mg kg(-1) d(-1) intraperitoneally) and 10-(4-...

journal_title：Investigative ophthalmology & visual science

authors： Drel VR,Xu W,Zhang J,Kador PF,Ali TK,Shin J,Julius U,Slusher B,El-Remessy AB,Obrosova IG

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may indicate a degenerative and attempted regenerative response of nerve fibers to diabetes. The purpose of this study was to define alterations...

journal_title：Investigative ophthalmology & visual science

authors： Kallinikos P,Berhanu M,O'Donnell C,Boulton AJ,Efron N,Malik RA

更新日期：2004-02-01 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To characterize the response of cultured human retinal pigment epithelial (RPE) cells to lowered environmental oxygen. METHODS:The response of cultured RPE cells to lowered oxygen environments was compared to that of cell types of presumed high (Madin-Darby canine kidney [MDCK] cells, an epithelial cell line) ...

journal_title：Investigative ophthalmology & visual science

authors： Nash RW,McKay BS,Burke JM

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cel...

journal_title：Investigative ophthalmology & visual science

authors： Renno RZ,Delori FC,Holzer RA,Gragoudas ES,Miller JW

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SD-OCT) in healthy individuals. METHODS:In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear ...

journal_title：Investigative ophthalmology & visual science

authors： Celebi AR,Mirza GE

更新日期：2013-12-11 00:00:00

abstract：:Lenses from young rhesus monkeys were incubated in the presence of H2O2 or oxygen radical generating systems to determine their suitability as a model for investigating lenticular oxidative stress. Additionally, direct comparisons were made between the effects found with the monkey lenses and those observed with cultu...

journal_title：Investigative ophthalmology & visual science

authors： Zigler JS Jr,Lucas VA,Du XY

更新日期：1989-10-01 00:00:00

abstract：Purpose:To assess the feasibility of macular integrity assessment (MAIA) microperimetry (MP) in children. Also to establish representative outcome measures (differential light sensitivity, fixation stability, test-retest reliability) for children without visual impairment. Methods:Thirty-three adults and 33 children (...

journal_title：Investigative ophthalmology & visual science

authors： Jones PR,Yasoubi N,Nardini M,Rubin GS

更新日期：2016-11-01 00:00:00

abstract：Purpose:Geographic atrophy (GA) is the late stage of non-neovascular age-related macular degeneration. A lack of animal models for GA has hampered treatment efforts. Presented herein is a rat model for GA using subretinal injection of sodium iodate (NaIO3). Methods:Rats were given subretinal injections of NaIO3 (5 μg/...

journal_title：Investigative ophthalmology & visual science

authors： Bhutto IA,Ogura S,Baldeosingh R,McLeod DS,Lutty GA,Edwards MM

更新日期：2018-03-20 00:00:00

abstract：PURPOSE:To develop and apply microarray-based resequencing technology to detect sequence alterations in multiple autosomal recessive retinal disease genes on a single high-throughput platform. METHODS:Oligonucleotides corresponding to both strands of the target exons and the flanking intron sequences of 29,214 bp from...

journal_title：Investigative ophthalmology & visual science

authors： Mandal MN,Heckenlively JR,Burch T,Chen L,Vasireddy V,Koenekoop RK,Sieving PA,Ayyagari R

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Juvenile open-angle glaucoma (JOAG) differs from primary open-angle glaucoma in that it is usually a more severe phenotype and has an earlier age of onset. Optineurin was recently associated with a variant of POAG that is characterized by intraocular pressure within normal limits: normal-tension glaucoma. The p...

journal_title：Investigative ophthalmology & visual science

authors： Willoughby CE,Chan LL,Herd S,Billingsley G,Noordeh N,Levin AV,Buys Y,Trope G,Sarfarazi M,Héon E

更新日期：2004-09-01 00:00:00

abstract：:Recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing the shedding of herpes simplex virus type-1 (HSV-1) induced by 6-hydroxydopamine iontophoresis followed by topical epinephrine application in previously infected rabbit corneas. A treatment schedule of RIFN alpha D, two drops QID was...

journal_title：Investigative ophthalmology & visual science

authors： Mayers M,Matli M,Okumoto M,Samy M,Smolin G

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to deepen our knowledge on the basis of intrafamilial genetic heterogeneity of inherited retinal dystrophies (RD) to further discern the contribution of individual alleles to the pathology. METHODS:Families with intrafamilial locus and/or allelic heterogeneity were selected from a coh...

journal_title：Investigative ophthalmology & visual science

authors： Sánchez-Alcudia R,Cortón M,Ávila-Fernández A,Zurita O,Tatu SD,Pérez-Carro R,Fernandez-San Jose P,Lopez-Martinez MÁ,del Castillo FJ,Millan JM,Blanco-Kelly F,García-Sandoval B,Lopez-Molina MI,Riveiro-Alvarez R,Ayuso C

更新日期：2014-10-23 00:00:00

abstract：PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Weinreb RN

更新日期：2002-12-01 00:00:00