A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.

Abstract:

:For the ornithine fermentation pathway, described more than 70 years ago, genetic and biochemical information are still incomplete. We present here the experimental identification of the last four missing genes of this metabolic pathway. They encode L-ornithine racemase, (2R,4S)-2,4-diaminopentanoate dehydrogenase, and the two subunits of 2-amino-4-ketopentanoate thiolase. While described only for the Clostridiaceae to date, this pathway is shown to be more widespread.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Fonknechten N,Perret A,Perchat N,Tricot S,Lechaplais C,Vallenet D,Vergne C,Zaparucha A,Le Paslier D,Weissenbach J,Salanoubat M

doi

10.1128/JB.01777-08

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

3162-7

issue

9

eissn

0021-9193

issn

1098-5530

pii

JB.01777-08

journal_volume

191

pub_type

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