Abstract:
:Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs. Clinical drugs are the important causes of hyperbilirubinemia, especially for patients with certain pathologic conditions or with genetic variations. This article reviews hyperbilirubinemic pathophysiology with respect to the effects of clinical drugs. In addition, this review introduces a new formula that may be utilized to estimate the annual occurrences of drug-induced hyperbilirubinemia in a hospital. Variations in the genes of UDP-glucuronosyltransferases, organic anion-transporting polypeptides and multidrug resistance proteins are the predisposing factors for drug-induced hyperbilirubinemia; therefore, their genetic and ethnic polymorphisms are discussed.
journal_name
Drug Metab Revjournal_title
Drug metabolism reviewsauthors
Ah YM,Kim YM,Kim MJ,Choi YH,Park KH,Son IJ,Kim SGdoi
10.1080/03602530802341133subject
Has Abstractpub_date
2008-01-01 00:00:00pages
511-37issue
4eissn
0360-2532issn
1097-9883pii
903036341journal_volume
40pub_type
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