Abstract:
:The CYP4 family of cytochrome P450 enzymes and the mammalian peroxidases covalently bind their heme groups. In the CYP4 enzymes this involves one, and in the peroxidases two, covalent ester links between heme methys and carboxylic acid side-chains. In addition, in myeloperoxidase, a methionine forms a sulfonium link to a heme vinyl group. The ester links in both classes of proteins are autocatalytically formed. One role of the covalent bonds in peroxidases is to protect the heme group from modification by catalytically generated reactive products. The covalent heme bond in CYP4 enzymes contributes to their high preference for omega- over (omega-1)-hydroxylation.
journal_name
Drug Metab Revjournal_title
Drug metabolism reviewsauthors
Ortiz de Montellano PRdoi
10.1080/03602530802186439subject
Has Abstractpub_date
2008-01-01 00:00:00pages
405-26issue
3eissn
0360-2532issn
1097-9883pii
795101911journal_volume
40pub_type
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