Mechanism and role of covalent heme binding in the CYP4 family of P450 enzymes and the mammalian peroxidases.

Abstract:

:The CYP4 family of cytochrome P450 enzymes and the mammalian peroxidases covalently bind their heme groups. In the CYP4 enzymes this involves one, and in the peroxidases two, covalent ester links between heme methys and carboxylic acid side-chains. In addition, in myeloperoxidase, a methionine forms a sulfonium link to a heme vinyl group. The ester links in both classes of proteins are autocatalytically formed. One role of the covalent bonds in peroxidases is to protect the heme group from modification by catalytically generated reactive products. The covalent heme bond in CYP4 enzymes contributes to their high preference for omega- over (omega-1)-hydroxylation.

journal_name

Drug Metab Rev

journal_title

Drug metabolism reviews

authors

Ortiz de Montellano PR

doi

10.1080/03602530802186439

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

405-26

issue

3

eissn

0360-2532

issn

1097-9883

pii

795101911

journal_volume

40

pub_type

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