Abstract:
:The body is considered as a system composed of a number of subsystems. The response(s) of a drug is a complicated function of the concentration in the blood plasma, which in turn is some function of the dosage input. The dose-response curve of a drug in a subsystem (e.g., isolated organ) is, over a limited concentration range, a linear function of the logarithm of the concentration. The logarithm of the concentration in the plasma is, again over a limited range, a linear function of time. Time-effect curves in the intact organism may therefore be a linear function of time. In reality, the situation is far more complex, because of nonlinear kinetics, nonlinear kinetics of effects in the subsystems, and adaptation phenomena based on feedback regulation, as is illustrated by examples. It is concluded that one should not only consider the body as a system but also study it as a system; that is, apply the dynamic system approach in pharmacology.
journal_name
Drug Metab Revjournal_title
Drug metabolism reviewsauthors
van Rossum JM,Burgers JPdoi
10.3109/03602538409015072subject
Has Abstractpub_date
1984-01-01 00:00:00pages
365-82issue
1-2eissn
0360-2532issn
1097-9883journal_volume
15pub_type
杂志文章,评审abstract::In summary, the concerns that environmental and other agents are causing adverse effects on reproductive function in humans are real, although the risk is not necessarily well characterized. The range of concerns for the types of effect that agents might have on reproduction span the full range of reproductive events....
journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602539608993992
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1081/dmr-120000653
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602532.2011.608682
更新日期:2011-11-01 00:00:00
abstract::Bupropion is an atypical antidepressant of the aminoketone group, structurally related to cathinone, associated with a wide interindividual variability. An extensive pharmacokinetic and pharmacodynamic review of bupropion was performed, also focusing on chemical, pharmacological, toxicological, clinical and forensic a...
journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1080/03602532.2019.1620763
更新日期:2019-08-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602539408998321
更新日期:1994-01-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602538808994135
更新日期:1988-01-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1080/03602530500205275
更新日期:2005-01-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1081/dmr-100101933
更新日期:1999-05-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602539709002238
更新日期:1997-11-01 00:00:00
abstract::Cyclindole was extensively metabolized and eliminated primarily via the kidneys from most laboratory animals and man. Only in the dog was cyclindole a major urinary component. Cyclindole was metabolized by N-demethylation and/or hydroxylation. In studies utilizing radiolabeled drug, the primary urinary component was p...
journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602538008994027
更新日期:1980-01-01 00:00:00
abstract::An association between marijuana use and schizophrenia has been noted for decades, and the recent emergence of high-efficacy synthetic cannabinoids (SCBs) as drugs of abuse has lead to a growing number of clinical reports of persistent psychotic effects in users of these substances. The mechanisms underlying SCB-elici...
journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1080/03602532.2018.1428343
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1081/dmr-100102335
更新日期:2000-08-01 00:00:00
abstract::Gold Nanostars (GNS) have attracted tremendous attention toward themselves owing to their multi-branched structure and unique properties. These state of the art metallic nanoparticles possess intrinsic features like remarkable optical properties and exceptional physiochemical activities. These star-shaped gold nanopar...
journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1080/03602532.2020.1734021
更新日期:2020-05-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.1080/03602532.2018.1428342
更新日期:2018-02-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602532.2015.1124888
更新日期:2016-01-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
doi:10.3109/03602532.2011.602688
更新日期:2012-02-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章
doi:10.1080/03602530701498612
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
doi:10.1080/03602532.2017.1415928
更新日期:2018-05-01 00:00:00
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更新日期:2014-08-01 00:00:00
abstract::The lung, which is in intimate contact with the external environment, is exposed to a number of toxicants both by virtue of its large surface area and because it receives 100% of the cardiac output. Lung diseases are a major disease entity in the U.S. population ranking third in terms of morbidity and mortality. Despi...
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更新日期:1984-01-01 00:00:00
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journal_title:Drug metabolism reviews
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更新日期:2013-11-01 00:00:00
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journal_title:Drug metabolism reviews
pub_type: 杂志文章,评审
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更新日期:2004-05-01 00:00:00
abstract::Herbert Remmer was a pioneer in the study of the phenomenon of enzyme induction. He was also a leading figure, if not the foremost, in the development of the discipline of toxicology in Germany during his tenure as Professor of Toxicology at the University of Tübingen. Included here are some brief thoughts about where...
journal_title:Drug metabolism reviews
pub_type: 传,历史文章,杂志文章
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更新日期:2004-10-01 00:00:00