Abstract:
:In summary, we have shown that steroid D-ring, but not steroid A-ring, glucuronide conjugates act at the level of the bile canaliculus to decrease bile-acid-dependent flow, initially; and subsequently, bile-acid-independent flow. These data indicate that glucuronide conjugates are not necessarily inactive; the present glucuronides clearly possess toxicological activity. The cholestatic glucuronides are all natural, endogenously formed products of metabolism. The critical questions which remain are whether metabolism of steroids to D-ring glucuronides is an obligatory step in the etiology of steroid-induced cholestasis and whether these glucuronides, at concentrations attained in humans, are capable of decreasing hepatic excretory function and inducing morphological and biochemical changes of clinical importance.
journal_name
Drug Metab Revjournal_title
Drug metabolism reviewsauthors
Vore M,Montgomery C,Meyers Mdoi
10.3109/03602538308991419subject
Has Abstractpub_date
1983-01-01 00:00:00pages
1005-19issue
5eissn
0360-2532issn
1097-9883journal_volume
14pub_type
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