Novel pathways associated with quinone-induced stress in breast cancer cells.

abstract：:Glutathione S-transferase P1-1 (GSTP) is one member of the family of GSTs and is ubiquitously expressed in human tissues. The literature is replete with reports of high levels of GSTP linked either with cancer incidence or drug resistance, and yet no entirely cogent explanation for these correlations exists. The catal...

journal_title：Drug metabolism reviews

authors： Tew KD,Townsend DM

更新日期：2011-05-01 00:00:00

abstract：:An association between marijuana use and schizophrenia has been noted for decades, and the recent emergence of high-efficacy synthetic cannabinoids (SCBs) as drugs of abuse has lead to a growing number of clinical reports of persistent psychotic effects in users of these substances. The mechanisms underlying SCB-elici...

journal_title：Drug metabolism reviews

authors： Fantegrossi WE,Wilson CD,Berquist MD

更新日期：2018-02-01 00:00:00

abstract：:Herbert Remmer was a pioneer in the study of the phenomenon of enzyme induction. He was also a leading figure, if not the foremost, in the development of the discipline of toxicology in Germany during his tenure as Professor of Toxicology at the University of Tübingen. Included here are some brief thoughts about where...

journal_title：Drug metabolism reviews

authors： Guengerich FP

更新日期：2004-10-01 00:00:00

abstract：:Dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. The previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. To date, activation of the p...

journal_title：Drug metabolism reviews

authors： Webb SJ,Geoghegan TE,Prough RA,Michael Miller KK

更新日期：2006-01-01 00:00:00

abstract：:Human cytochrome P450 (CYP) 3A subfamily members (mainly CYP3A4 and CYP3A5) mediate the metabolism of approximately half all marketed drugs and thus play a critical role in the drug metabolism. A huge number of studies on CYP3A-mediated drug metabolism in humans have demonstrated that CYP3A activity exhibits marked et...

journal_title：Drug metabolism reviews

authors： Liu YT,Hao HP,Liu CX,Wang GJ,Xie HG

更新日期：2007-01-01 00:00:00

abstract：:Ronald Estabrook made his initial impact studying cytochrome P450 by demonstrating the oxidative metabolism function of this unique class of enzymes, which had an unusual spectral peak at 450 nm when reduced and in the presence of carbon monoxide. Utilizing a photochemical action spectrum, he demonstrated that a cytoc...

journal_title：Drug metabolism reviews

authors： Sheets JJ

更新日期：2007-01-01 00:00:00

abstract：:Pregnane X receptor (PXR) and constitutive active/androstane receptor (CAR), members of the nuclear receptor superfamily, are two major xeno-sensing transcription factors. They can be activated by a broad range of lipophilic xenobiotics including therapeutics drugs. In addition to xenobiotics, endogenous compounds suc...

journal_title：Drug metabolism reviews

authors： Kodama S,Negishi M

更新日期：2013-11-01 00:00:00

abstract：:The rat P450IIA subfamily was characterized at the protein, cDNA, and gene level. The purified IIA1 and IIA2 P-450s displayed distinct positional specificities toward hydroxylation of the prototype substrate testosterone. The IIA1 and IIA2 genes were also regulated differently during development; IIA1 was expressed wi...

journal_title：Drug metabolism reviews

authors： Gonzalez FJ,Matsunaga T,Nagata K

更新日期：1989-01-01 00:00:00

abstract：:In this review of the literature on surface-enhanced Raman scattering (SERS), we describe recent developments of this technique in the medical field. SERS has developed rapidly in the last few years as a result of the fascinating advancements in instrumentation and the ability to interpret complex Raman data using hig...

journal_title：Drug metabolism reviews

authors： Nima ZA,Biswas A,Bayer IS,Hardcastle FD,Perry D,Ghosh A,Dervishi E,Biris AS

更新日期：2014-05-01 00:00:00

abstract：:Cytochrome P450 (CYP) 2D6 is one of the most important enzymes involved in the metabolism of drugs. Multiple, clinically relevant, genetic variants of this gene have been identified and, among them, a gene deletion as well as multiplications of the gene. These large structural mutations in CYP2D6 occur at a relatively...

journal_title：Drug metabolism reviews

authors： Meijerman I,Sanderson LM,Smits PH,Beijnen JH,Schellens JH

更新日期：2007-01-01 00:00:00

abstract：:The recent progresses in molecular biology and pharmacology approaches allowed the characterization of a series of nuclear receptors (NRs) as efficient regulators of uridine diphosphate glucuronosyltransferase (UGT) genes activity. These regulatory processes ensure an optimized UGT expression in response to specific e...

journal_title：Drug metabolism reviews

authors： Bigo C,Caron S,Dallaire-Théroux A,Barbier O

更新日期：2013-02-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with decreased quality of life, and increased mortality and morbidity from stroke and thromboembolism. The underlying mechanisms involved in the development of AF have yet to be fully elucidated. However, once initiated, AF t...

journal_title：Drug metabolism reviews

authors： Orenes-Piñero E,Valdés M,Lip GY,Marín F

更新日期：2015-08-01 00:00:00

abstract：:Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic releva...

journal_title：Drug metabolism reviews

authors： Dinis-Oliveira RJ

更新日期：2017-02-01 00:00:00

abstract：:In this case study, in vitro and in vivo data were provided for saquinavir (SQV) showing that drug transporters play a significant role in the absorption and disposition of drugs. This article is focused on the more practical points with a technical emphasis. Currently many in vitro and in vivo experimental models hav...

journal_title：Drug metabolism reviews

authors： Su Y,Lee SH,Sinko PJ

更新日期：2004-05-01 00:00:00

abstract：:Voriconazole, a second-generation triazole frequently used for the prophylaxis and treatment of invasive fungal infections, undergoes complex metabolism mainly involving various (polymorphic) cytochrome P450 enzymes in humans. Although high inter- and intraindividual variability in voriconazole pharmacokinetics have b...

journal_title：Drug metabolism reviews

authors： Schulz J,Kluwe F,Mikus G,Michelet R,Kloft C

更新日期：2019-08-01 00:00:00

abstract：:Historically, failure rates in drug development are high; increased sophistication and investment throughout the process has shifted the reasons for attrition, but the overall success rates have remained stubbornly and consistently low. Only 8% of new entities entering clinical testing gain regulatory approval, indica...

journal_title：Drug metabolism reviews

authors： Maharao N,Antontsev V,Wright M,Varshney J

更新日期：2020-05-01 00:00:00

abstract：:The high rate of attrition during drug development and its associated high research and development (R&D) cost have put pressure on pharmaceutical companies to ensure that candidate drugs going to clinical testing have the appropriate quality such that the biological hypothesis could be evaluated. To help achieve this...

journal_title：Drug metabolism reviews

authors： Ballard P,Brassil P,Bui KH,Dolgos H,Petersson C,Tunek A,Webborn PJ

更新日期：2012-08-01 00:00:00

abstract：:In summary, the concerns that environmental and other agents are causing adverse effects on reproductive function in humans are real, although the risk is not necessarily well characterized. The range of concerns for the types of effect that agents might have on reproduction span the full range of reproductive events....

journal_title：Drug metabolism reviews

authors： Schwetz BA

更新日期：1996-02-01 00:00:00

abstract：:Traditional Chinese medicine (TCM) has a long history of medical use in China and is still used worldwide. Unexpected herb-drug interactions (HDIs) may lead to adverse drug reactions or loss of therapeutic efficacy of the victim drug. Here, based on searches of Medline, EBSCO, Science Direct and Web of Science using v...

journal_title：Drug metabolism reviews

authors： Ma BL,Ma YM

更新日期：2016-01-01 00:00:00

abstract：:The efficacy of drugs has to be demonstrated following the principal approach of statistical evaluation in controlled clinical trials. This scientifically and internationally accepted numerical approach has developed over the years to its importance, in contrast to the more pharmacologically attempt to extrapolate hum...

journal_title：Drug metabolism reviews

authors： Hildebrandt AG

更新日期：2004-10-01 00:00:00

abstract：:Acetaminophen (APAP, paracetamol, N-acetyl-p-aminophenol) is a widely used analgesic that is safe at therapeutic doses but is a major cause of acute liver failure (ALF) following overdose. APAP-induced hepatotoxicity is related to the formation of an electrophilic reactive metabolite, N-acetyl-p-benzoquinone imine (NA...

journal_title：Drug metabolism reviews

authors： Coen M

更新日期：2015-02-01 00:00:00

abstract：:A number of therapeutic drugs with different structures and mechanisms of action have been reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes. The bioactivation gives rise to reactive metabolites/intermediates, which readily confer covalent binding to various target proteins by n...

journal_title：Drug metabolism reviews

authors： Zhou S,Chan E,Duan W,Huang M,Chen YZ

更新日期：2005-01-01 00:00:00

abstract：:The multistep, clonal evolution model of cancer predicts fundamental mechanisms by which chemicals may influence the cancer process. These are illustrated by studies of the mechanisms of induction of carcinogenesis by estrogens and the inhibition of carcinogenesis by caloric restriction. ...

journal_title：Drug metabolism reviews

authors： Barrett JC

更新日期：2000-05-01 00:00:00

abstract：:Adverse pharmacokinetic interactions between illicit substances and clinical drugs are of a significant health concern. Illicit substances are taken by healthy individuals as well as by patients with medical conditions such as mental illnesses, acquired immunodeficiency syndrome, diabetes mellitus and cancer. Many ind...

journal_title：Drug metabolism reviews

authors： Abbott KL,Flannery PC,Gill KS,Boothe DM,Dhanasekaran M,Mani S,Pondugula SR

更新日期：2020-02-01 00:00:00

abstract：:Synthetic cannabinoids (SC), originally developed as research tools, are now highly abused novel psychoactive substances. We present a comprehensive systematic review covering in vivo and in vitro animal and human pharmacokinetics and analytical methods for identifying SC and their metabolites in biological matrices. ...

journal_title：Drug metabolism reviews

authors： Castaneto MS,Wohlfarth A,Desrosiers NA,Hartman RL,Gorelick DA,Huestis MA

更新日期：2015-05-01 00:00:00

abstract：:Indirect evidence for the participation of cytochrome P450 (P450) in the microsomal N-oxygenation of primary and N-substituted amine functions is presented by studies employing diagnostic modifiers of the hemoprotein system as well as immunochemical approaches. Experiments with recombinant hemoproteins or isozymes pur...

journal_title：Drug metabolism reviews

authors： Hlavica P

更新日期：2002-08-01 00:00:00

abstract：:The body is considered as a system composed of a number of subsystems. The response(s) of a drug is a complicated function of the concentration in the blood plasma, which in turn is some function of the dosage input. The dose-response curve of a drug in a subsystem (e.g., isolated organ) is, over a limited concentrati...

journal_title：Drug metabolism reviews

authors： van Rossum JM,Burgers JP

更新日期：1984-01-01 00:00:00

abstract：:Drug transporters and drug metabolism enzymes govern drug absorption, distribution, metabolism and elimination. Many literature works presenting important aspects related to stereochemistry of drug metabolism are available. However, there is very little literature on stereoselectivity of chiral drug transport and enan...

journal_title：Drug metabolism reviews

authors： Zhou Q,Yu LS,Zeng S

更新日期：2014-08-01 00:00:00

abstract：:In this paper, we evaluate methodologies and null mouse models used to study drug transporter function in vitro and in vivo. P-glycoprotein and MRP null mice have been used to examine many aspects of xenobiotic distribution and bioavailability. Their advantage over conventional models is that they allow the exclusion ...

journal_title：Drug metabolism reviews

authors： Stanley LA,Horsburgh BC,Ross J,Scheer N,Wolf CR

更新日期：2009-01-01 00:00:00

abstract：:For patients undergoing cardiopulmonary bypass (CPB) during cardiac surgery, there are well-documented changes in the pharmacokinetics (PK) of commonly administered drugs. Although multiple factors potentially underpin these changes, there has been scant research attention on the impact of CPB to alter the activities ...

journal_title：Drug metabolism reviews

authors： Adiraju SKS,Shekar K,Fraser JF,Smith MT,Ghassabian S

更新日期：2018-05-01 00:00:00