The biological actions of dehydroepiandrosterone involves multiple receptors.

Abstract:

:Dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. The previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. To date, activation of the peroxisome proliferators activated receptor alpha, pregnane X receptor, and estrogen receptor by DHEA and its metabolites have been demonstrated. Several membrane-associated receptors have also been elucidated leading to additional mechanisms by which DHEA may exert its biological effects. This review will provide an overview of the receptor multiplicity involved in the biological activity of this sterol.

journal_name

Drug Metab Rev

journal_title

Drug metabolism reviews

authors

Webb SJ,Geoghegan TE,Prough RA,Michael Miller KK

doi

10.1080/03602530600569877

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

89-116

issue

1-2

eissn

0360-2532

issn

1097-9883

pii

L5810651614985N3

journal_volume

38

pub_type

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