Abstract:
:The aim of this study was to evaluate diazepam and oxazepam as cytochrome P450 inducers at doses previously shown to cause liver tumors in mice but not rats. In rats, diazepam and oxazepam induced CYP2B, and were as effective as phenobarbital despite lacking phenobarbital's tumor-promoting effect in rats. In mice, diazepam and oxazepam induced both CYP2B and CYP4A at dietary doses associated with liver tumor formation. It remains to be determined why diazepam and oxazepam induce CYP4A in mice but not rats and whether this difference accounts for the apparent species difference in the tumor-promoting activity of diazepam and oxazepam.
journal_name
Drug Metab Revjournal_title
Drug metabolism reviewsauthors
Parkinson A,Leonard N,Draper A,Ogilvie BWdoi
10.1080/03602530600570081subject
Has Abstractpub_date
2006-01-01 00:00:00pages
235-59issue
1-2eissn
0360-2532issn
1097-9883pii
MN7573361L153264journal_volume
38pub_type
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