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Synaptic vesicle fusion.

Abstract：

:The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion. In addition, SNARE complex assembly is likely orchestrated by Munc13s and RIMs, active-zone proteins that function in vesicle priming and diverse forms of presynaptic plasticity. Synaptotagmin-1 mediates triggering of release by Ca2+, probably through interactions with SNAREs and both membranes, as well as through a tight interplay with complexins. Elucidation of the release mechanism will require a full understanding of the network of interactions among all these proteins and the membranes.

journal_name

Nat Struct Mol Biol

journal_title

Nature structural & molecular biology

authors

Rizo J,Rosenmund C

doi

10.1038/nsmb.1450

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

665-74

issue

7

eissn

1545-9993

issn

1545-9985

journal_volume

15

pub_type

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