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Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

Abstract：

:Methylation of histones is central to chromatin regulation, and thus previously unknown mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here we identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast. Set5's enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses.

journal_name

Nat Struct Mol Biol

journal_title

Nature structural & molecular biology

authors

Green EM,Mas G,Young NL,Garcia BA,Gozani O

doi

10.1038/nsmb.2252

subject

Has Abstract

pub_date

2012-02-19 00:00:00

pages

361-3

issue

3

eissn

1545-9993

issn

1545-9985

pii

nsmb.2252

journal_volume

19

pub_type

杂志文章

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