T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections.


:Multidrug-resistant uropathogenic Escherichia coli (UPEC) is increasing gradually on a worldwide scale. We therefore examined the possibility of bacteriophage (phage) therapy for urinary tract infections (UTIs) caused by the UPEC strains as an alternative to chemotherapy. In addition to the well-known T4 phage, KEP10, which was newly isolated, was used as a therapeutic phage candidate. KEP10 showed a broader bacteriolytic spectrum (67%) for UPEC strains than T4 (14%). Morphological and genetic analyses showed that KEP10 resembles phage T4. Phages T4 and KEP10 injected into the peritoneal cavity of mice were distributed immediately to all organs examined and maintained a high titer for at least 24 h. They were stable in the urine of both mice and humans for 24 h at 37 degrees C. Administration of these phages into the peritoneal cavity caused a marked decrease in the mortality of mice inoculated transurethrally with a UPEC strain, whereas most of the control mice died within a few days of bacterial infection. Inoculation with phage alone produced no adverse effects attributable to the phage per se. The present study experimentally demonstrated the therapeutic potential of phage for E. coli-induced UTIs, and T-even-related phages may be suitable candidates with which to treat them.


Arch Virol


Archives of virology


Nishikawa H,Yasuda M,Uchiyama J,Rashel M,Maeda Y,Takemura I,Sugihara S,Ujihara T,Shimizu Y,Shuin T,Matsuzaki S




Has Abstract


2008-01-01 00:00:00












  • Identification of amino acids in highly pathogenic avian influenza H5N1 virus hemagglutinin that determine avian influenza species specificity.

    abstract::To test the role of neutralizing antibodies (nAbs) and receptor adaptation in interspecies transmission of influenza virus, two H5N1 strains, isolated from human and avian hosts, with four amino acid differences in hemagglutinin (HA) and seven HA mutations were studied. We found that a mutation at amino acid position ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Li Z,Liu Z,Ma C,Zhang L,Su Y,Gao GF,Li Z,Cui L,He W

    更新日期:2011-10-01 00:00:00

  • Complete nucleotide sequence and phylogeny of an American strain of yellow fever virus, TRINID79A.

    abstract::Yellow fever was presumably imported to the Americas from West-Africa from the 16th to the 19th century. American and African genotypes of the virus are distinguishable, indicating separate evolution in different vector/host cycles. The complete nucleotide sequence of the yellow fever virus strain TRINID79A, isolated ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Pisano MR,Mercier V,Deubel V,Tolou H

    更新日期:1999-01-01 00:00:00

  • Five measles virus antigens demonstrated by use of mouse hybridoma antibodies in productively infected tissue culture cells.

    abstract::Mouse hybridoma antibodies against 5 different structural components of measles virus were used in immune fluorescence tests to characterize the appearance of viral antigens in productively infected cell cultures. The antibodies employed in the tests reacted specifically with the hemagglutinin (H, 79K), polymerase (P,...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Norrby E,Chen SN,Togashi T,Shesberadaran H,Johnson KP

    更新日期:1982-01-01 00:00:00

  • Evidence that virion-associated VP1 of avibirnaviruses contains viral RNA sequences.

    abstract::The VP1 encoded by genomic segment B of birnaviruses is generally known to exist as a genome-linked protein (VPg) and as a "free" polypeptide of 90 kDa in virus particles. The guanylylation activity associated with infectious bursal disease virus (IBDV) was demonstrated by incubating purified virus in presence of [alp...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Kibenge FS,Dhama V

    更新日期:1997-01-01 00:00:00

  • Molecular characterization of two genotypes of a new polerovirus infecting brassicas in China.

    abstract::The genomic RNA sequences of two genotypes of a brassica-infecting polerovirus from China were determined. Sequence analysis revealed that the virus was closely related to but significantly different from turnip yellows virus (TuYV). This virus and other poleroviruses, including TuYV, had less than 90% amino acid sequ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Xiang HY,Dong SW,Shang QX,Zhou CJ,Li DW,Yu JL,Han CG

    更新日期:2011-12-01 00:00:00

  • Rotaviruses belonging to the AU-1 genogroup recovered from Israeli infants with diarrhea.

    abstract::The genetic and antigenic diversity of group A rotaviruses recovered from Israeli infants has been expanded recently by the inclusion of three unusual human rotavirus strains. Two rotavirus strains (Ro-5829 and Ro-5960) were shown to be the first viruses outside Japan that resembled the AU-1 genogroup of feline like h...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Shif I,Iizuka M,Silberstein I,Mendelson E,Nakagomi O

    更新日期:1994-01-01 00:00:00

  • Avian reovirus σA and σNS proteins activate the phosphatidylinositol 3-kinase-dependent Akt signalling pathway.

    abstract::The present study was conducted to identify avian reovirus (ARV) proteins that can activate the phosphatidylinositol 3-kinase (PI3K)-dependent Akt pathway. Based on ARV protein amino acid sequence analysis, σA, σNS, μA, μB and μNS were identified as putative proteins capable of mediating PI3K/Akt pathway activation. T...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Xie L,Xie Z,Huang L,Fan Q,Luo S,Huang J,Deng X,Xie Z,Zeng T,Zhang Y,Wang S

    更新日期:2016-08-01 00:00:00

  • Genetic characterization of H5N1 avian influenza viruses isolated in southern China during the 2003-04 avian influenza outbreaks.

    abstract::The recent H5N1 avian influenza outbreaks in Asia spread over more than 8 countries. It has caused enormous economic loss and grand challenges for the public health. During these breakouts we isolated three strains of H5N1 Avian Influenza Virus (AIV) from chickens and one from duck in different farms of Southern China...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Wan XF,Ren T,Luo KJ,Liao M,Zhang GH,Chen JD,Cao WS,Li Y,Jin NY,Xu D,Xin CA

    更新日期:2005-06-01 00:00:00

  • Cell-line-dependent crystal morphology and sublocalization of the Thyrinteina arnobia cypovirus polyhedrin expressed from a recombinant baculovirus.

    abstract::We describe an unexpected feature observed for the heterologous expression of the Thyrinteina arnobia cypovirus polyhedrin from a recombinant baculovirus infection in different insect cell lines. The in cellulo-formed crystals varied in size and shape depending on the cell line. Crystals formed in Trichoplusia ni-deri...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Silva LA,Ardisson-Araújo DMP,Morgado FS,Horta AB,Lemos MVF,Wilcken CF,Ribeiro BM

    更新日期:2019-06-01 00:00:00

  • DNA vaccination induces a long-term antibody response and protective immunity against pseudorabies virus in mice.

    abstract::In order to investigate the mechanism of long-term immunity and the effect of protective immunity induced by DNA vaccination, we constructed the expression plasmid containing a pseudorabies virus (PRV) gD gene encoding an envelope glycoprotein. Intramuscular vaccination of mice with the plasmid DNA induced a strong an...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ho TY,Hsiang CY,Hsiang CH,Chang TJ

    更新日期:1998-01-01 00:00:00

  • Characterization of a distinct Johnsongrass mosaic virus strain isolated from sorghum in Nigeria.

    abstract::A virus isolated from sorghum in Nigeria has been partially characterized. It was tested by enzyme-linked immunosorbent assay (ELISA) using antisera to Maize dwarf mosaic virus, Johnsongrass mosaic virus (JGMV), Sugarcane mosaic virus strain-MDB, Sorghum mosaic virus, and Zea mosaic virus. A partial host range, sympto...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Seifers DL,Haber S,Ens W,She YM,Standing KG,Salomon R

    更新日期:2005-03-01 00:00:00

  • B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors.

    abstract::It has been suggested that antibody overproduction plays a role in the pathogenesis of feline infectious peritonitis (FIP). However, only a few studies on the B-cell activation mechanism after FIP virus (FIPV) infection have been reported. The present study shows that: (1) the ratio of peripheral blood sIg(+) CD21(-) ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Takano T,Azuma N,Hashida Y,Satoh R,Hohdatsu T

    更新日期:2009-01-01 00:00:00

  • Inhibition by monensin of human cytomegalovirus DNA replication.

    abstract::Monensin, at concentrations which depended on the multiplicity of infection, was found to prevent DNA replication of human cytomegalovirus (HCMV) as well as production of viral progeny in human foreskin fibroblasts. The drug did not affect DNA replication of herpes simplex virus. Inhibition of consecutive HCMV DNA syn...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Kaiser CJ,Radsak K

    更新日期:1987-01-01 00:00:00

  • Strain-dependent differences in the human cytomegalovirus replication origin.

    abstract::The nucleotide sequence of the human cytomegalovirus replication origin of strain Towne (an AatII-SacI fragment corresponding to nt 90372-94637 of strain AD169) was determined and compared with AD169. Two differences were found in the nucleotide sequence level. One was the alteration of structural organization (a majo...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Chen Z,Watanabe S,Yamaguchi N

    更新日期:1996-01-01 00:00:00

  • Close relationship between mink influenza (H10N4) and concomitantly circulating avian influenza viruses.

    abstract::Strains of an influenza H10N4 virus have been isolated during an outbreak of a respiratory disease in mink on the south-east coast of Sweden. This was the first example of a disease in mammals caused by the H10 subtype. We compared the A/mink/Sweden/84 strain with two recent avian H10N4 isolates, one from fowl and ano...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Berg M,Englund L,Abusugra IA,Klingeborn B,Linné T

    更新日期:1990-01-01 00:00:00

  • [Local immune response in mouse experimental airborne influenza: immunoglobulin concentrations, antibody levels of immunoglobulin classes and anamnestic response in bronchial washings (author's transl)].

    abstract::Sera and bronchial washings from normal mice and from mice previously infected with influenza virus were analyzed for their concentration of four immunoglobulin (Ig) classes by the method of single radial immunodiffusion and for their content of specific antibody of these Ig classes by the immunofluorescent method. Ig...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Lemercier G,Neveu D,Morel J,Fontanges R

    更新日期:1977-01-01 00:00:00

  • A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses.

    abstract::Mosquito-borne alphaviruses are widely distributed throughout the world, causing important human illnesses. Therefore, the development of methods to enable early diagnosis of infections by alphavirus is essential. We show here the development and evaluation of a quantitative real-time RT-PCR using genus-specific prime...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Romeiro MF,de Souza WM,Tolardo AL,Vieira LC,Henriques DA,de Araujo J,Siqueira CE,Colombo TE,Aquino VH,da Fonseca BA,de Morais Bronzoni RV,Nogueira ML,Durigon EL,Figueiredo LT

    更新日期:2016-11-01 00:00:00

  • Current status of African swine fever virus in a population of wild boar in eastern Poland (2014-2015).

    abstract::African swine fever virus (ASFV) was detected in wild boar in eastern Poland in early 2014. So far, 65 cases of ASFV infection in wild boar have been recognised. The methods used for ASFV detection included highly specific real-time PCR with a universal probe library (UPL), enzyme-linked immunosorbent assay (ELISA), a...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Woźniakowski G,Kozak E,Kowalczyk A,Łyjak M,Pomorska-Mól M,Niemczuk K,Pejsak Z

    更新日期:2016-01-01 00:00:00

  • Characterization of a soybean mosaic virus variant causing different diseases in Glycine max and Nicotiana benthamiana.

    abstract::We discovered a soybean mosaic virus (SMV) variant (4278-1) that caused systemic infections in Nicotiana benthamiana plants, resulting in stem stunting and leaf shriveling. The virus had a particle morphology and incubation period similar to those of other SMV isolates but differed from them in the leaf symptoms it ca...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Jiang H,Li K,Dou D,Gai J

    更新日期:2017-02-01 00:00:00

  • Characterisation of a new potyvirus species infecting meadow saffron Colchicum autumnale).

    abstract::The alkaloids contained in Colchicum autumnale seeds are used in numerous medicines. Good quality seeds are difficult to obtain from this undomesticated plant. Therefore, a research program was set up aiming to cultivate C. autumnale in order to improve alkaloid contents and seed yields. In this context, a collection ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Poutaraud A,Desbiez C,Lemaire O,Lecoq H,Herrbach E

    更新日期:2004-07-01 00:00:00

  • Effectiveness of first-line antiretroviral therapy in HIV/AIDS patients: A 5-year longitudinal evaluation in Fujian Province, Southeast China.

    abstract::The aim of this study was to evaluate the long-term effectiveness of first-line antiretroviral therapy in HIV/AIDS patients in Southeast China. A total of 450 eligible patients were selected to initiate first-line antiretroviral therapy from February 2005 through August 2009. During the study period from 2009 through ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Wu S,Qiu Y,Yan P,Wang W,Xie M,Xia P,Wang Z,Yan Y

    更新日期:2015-11-01 00:00:00

  • Additional changes to taxonomy ratified in a special vote by the International Committee on Taxonomy of Viruses (October 2018).

    abstract::This article reports the changes to virus taxonomy approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in October 2018. Of note, the ICTV has approved, by an absolute majority, the creation of additional taxonomical ranks above those recognized previously. A total of 15 ranks (realm, sub...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Siddell SG,Walker PJ,Lefkowitz EJ,Mushegian AR,Adams MJ,Dutilh BE,Gorbalenya AE,Harrach B,Harrison RL,Junglen S,Knowles NJ,Kropinski AM,Krupovic M,Kuhn JH,Nibert M,Rubino L,Sabanadzovic S,Sanfaçon H,Simmonds P,Varsa

    更新日期:2019-03-01 00:00:00

  • Modified radial-plaque-neutralization test for demonstration of enterovirus neutralizing antibodies.

    abstract::A simple radial method based on the formerly described paper disc technique was developed for demonstration of neutralizing antibodies to enteroviruses with plaque forming ability. Sera administered by 5 microliter wire-loops to wells cut into the agar overlay of virus infected cell monolayers produced radial neutrali...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Nagy G,Takátsy S

    更新日期:1980-01-01 00:00:00

  • Rotavirus infection in lambs: studies on passive protection.

    abstract::Gnotobiotic lambs were protected against rotavirus infection by the presence in the gut at the time of infection of colostrum or serum containing antibodies to rotavirus. This protection was observed even when passively-acquired antibody was not present in the serum of the infected lamb. Infection under these conditio...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Snodgrass DR,Wells PW

    更新日期:1976-01-01 00:00:00

  • Serological and molecular variability of watermelon mosaic virus (genus Potyvirus).

    abstract::Watermelon mosaic virus (WMV, genus Potyvirus) is very common in cucurbits worldwide, but its variability has been little studied. In France, where WMV has been known since 1974, unusually severe symptoms on zucchini squash have been found to be associated with WMV since 1999. We have developed serological and molecul...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Desbiez C,Costa C,Wipf-Scheibel C,Girard M,Lecoq H

    更新日期:2007-01-01 00:00:00

  • Enterovirus C strains circulating in Nigeria and their contribution to the emergence of recombinant circulating vaccine-derived polioviruses.

    abstract::Between 2005 and 2011, 23 lineages of circulating vaccine-derived polioviruses (cVDPVs) were detected in Nigeria with nonstructural region (NSR) of non-polio enterovirus C (NPEV-C) origin. However, no information exists on NPEV-C strains recombining with oral poliovirus type 2 vaccine strains (OPV2) to make type 2 cVD...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Adeniji JA,Faleye TO

    更新日期:2015-03-01 00:00:00

  • Characterizations of natural and induced polyhedrin gene mutants of Bombyx mori cytoplasmic polyhedrosis viruses.

    abstract::Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) polyhedrin gene from natural mutant strain B, B2 and P was cloned and the amino acid sequence was compared with that of wild-type virus (strain H). Chimeric polyhedrin genes (8 types) containing only one site of mutation within the amino acid sequence were also constr...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ikeda K,Nakazawa H,Alain R,Belloncik S,Mori H

    更新日期:1998-01-01 00:00:00

  • Molecular characterization of adenoviral infections in Cuba: report of an unusual association of species D adenoviruses with different clinical syndromes.

    abstract::Adenoviruses are common pathogens that are responsible for a wide variety of infectious syndromes. The objectives of this study were to identify and characterize members of different adenovirus species at the molecular level and to describe the correlation between viruses and clinical syndromes during a period of 4 ye...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Belsy A,Odalys V,Alexander P,Clara S,Angel G,Grehete G,Guelsys G,Luis S,Pedro M,Guadalupe GM,Alina L,Pilar PB,Inmaculada C

    更新日期:2009-01-01 00:00:00

  • The role of epithelial cell differentiation in the expression of herpes simplex virus type 1 in normal human oral mucosa in culture.

    abstract::We have examined by immunofluorescent antibody staining technique the expression of herpes simplex virus type 1 (HSV-1) in organ cultures of the normal human oral mucosa. The expression of HSV-1 antigen was found selectively in the epithelial cell layers in relatively undifferentiated states such as basal layer and lo...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Yura Y,Iga H,Terashima K,Yoshida H,Yanagawa T,Hayashi Y,Sato M

    更新日期:1987-01-01 00:00:00

  • Epidemiology and genetic relatedness of measles virus infection in Uttar Pradesh, India, during 2009-2010.

    abstract::Measles surveillance and epidemiological investigation are beneficial tools for genetic analysis and documentation of the interruption of transmission of endemic measles. In this study, areas of Uttar Pradesh, India, associated with measles outbreaks were investigated. Random blood and urine samples were collected fro...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Shakya AK,Shukla V,Maan HS,Dhole TN

    更新日期:2012-04-01 00:00:00