Effects of three benzimidazoles on growth, general morphology and ultrastructure of Tritrichomonas foetus.

Abstract:

:Tritrichomonas foetus is a venereal pathogen of cattle, which causes infertility, early embryonic death or abortion. In order to evaluate the potential trichomonicidal activity of benzimidazoles, the effects of thiabendazole, mebendazole and albendazole were analyzed on the multiplication, general morphology and ultrastructure of T. foetus. It was found that mebendazole presented the highest IC(50%) (2.3 microM), when compared with albendazole (IC(50%)=9.4 microM) and thiabendazole (IC(50%)=142.6 microM), and that such effects were irreversible. Concerning microscopic analysis, thiabendazole- and mebendazole-treated cells presented increased volume, internalization of the flagella, disruption or multiplication of the nucleus, multiple organelles and cytoplasmic vacuolization. Albendazole-treated cells exhibited slight alterations, because the parasite became slightly rounded, its flagella were not internalized but the cytoplasm was vacuolated. Mebendazole was indeed highly effective as an in vitro trichomonicidal agent, and this might open up new possibilities for the use of mebendazole in the therapy of bovine trichomoniasis.

journal_name

FEMS Microbiol Lett

authors

Carvalho KP,Gadelha AP

doi

10.1111/j.1574-6968.2007.00897.x

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

292-300

issue

2

eissn

0378-1097

issn

1574-6968

pii

FML897

journal_volume

275

pub_type

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