Abstract：
:An increased level of plasma corticosterone is one manifestation of severe environmental or physiologic stress. The stress response mediated by the hypothalamic-pituitary-adrenal axis is already known to suppress immunoglobulin production and to impair immune function, but there are few studies relating stress and plasma corticosterone to the outcome of Trypanosoma cruzi infection. In this study, male Wistar rats were infected with the Y strain of T. cruzi and then subjected to repetitive stress by exposure to ether vapor for 1min twice a day during the acute phase of infection. Stressed animals showed decreased lytic antibody activity and lowered levels of peritoneal macrophages. Despite an increase in the weight of the spleen, histological analyses demonstrated tissue alterations, the presence of amastigote nests, and a complete absence of activated lymphoid follicles. These results suggest that stress-induced increases in plasma corticosterone can suppress the immune response and worsen tissue injury during the acute phase of T. cruzi infection.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Santos CD,Prado JC Jr,Toldo MP,Levy AM,Franci CR,Caldeira JCdoi
10.1016/j.exppara.2007.05.008subject
Has Abstractpub_date
2007-12-01 00:00:00pages
405-10issue
4eissn
0014-4894issn
1090-2449pii
S0014-4894(07)00155-5journal_volume
117pub_type
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