Abstract:
:A new direct-to-consumer genetic test purports to detect fetal gender as early as five weeks of pregnancy. The availability of this test highlights the consequences of the current system of oversight for genetic tests and underscores the need for an enhanced regulatory framework to ensure the accuracy, reliability, and validity of genetic tests.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Javitt GHdoi
10.1016/j.fertnstert.2006.03.016subject
Has Abstractpub_date
2006-07-01 00:00:00pages
13-5issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(06)00869-7journal_volume
86pub_type
社论abstract:OBJECTIVE:To review a 12-year experience of the world's three largest preimplantation genetic diagnosis (PGD) centers. DESIGN:Multicenter analysis of the clinical outcome of PGD. SETTING:In vitro fertilization programs at the Reproductive Genetics Institute, Chicago, Illinois; Saint Barnabas Medical Center, West Oran...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.09.082
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To investigate the testicular function in adolescents with pubertal gynecomastia associated with varicocele before and after varicocelectomy. DESIGN AND PATIENTS:We have studied six male adolescents 15 to 19 years of age with bilateral gynecomastia. They were selected among other adolescents with gynecomasti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54551-8
更新日期:1991-09-01 00:00:00
abstract::The health of children born through assisted reproductive technologies (ART) is particularly vulnerable to policy decisions and market forces that play out before they are even conceived. ART treatment is costly, and public and third-party funding varies significantly between and within countries, leading to considera...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2020.08.1405
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To investigate the direct effects of sodium nitroprusside, a nitric oxide donor, on the fertilizing ability of human spermatozoa in vitro. DESIGN:Prospective, controlled in vitro study. SETTING:IVF Unit, Medical College Hospital. PATIENT(S):Women undergoing conventional IVF. INTERVENTION(S):Human spermato...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00537-2
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To compare the low-dose recombinant FSH and hMG protocols in treatment of patients with history of severe ovarian hyperstimulation syndrome (OHSS). DESIGN:A prospective study on 22 patients with history of severe OHSS. Group A (n = 14) was treated with low-dose recombinant FSH 40 cycles and group B (n = 8) w...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)58631-2
更新日期:1996-11-01 00:00:00
abstract::To explore possible relationships between genital tract infections, sperm antibodies, and infertility, seminal fluid from 100 men was analyzed. Sperm antibodies, measured by an enzyme-linked immunosorbent assay, were detected in 14 of 29 men (48%) with culture-positive asymptomatic infections, 8 of 17 men (47%) with a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47484-4
更新日期:1983-12-01 00:00:00
abstract::Changes in the composition of media used for human in vitro fertilization and embryo culture are reviewed, and their impact on improved pregnancy rates is discussed. It is concluded that changes to the formulation of culture media for assisted reproductive technologies over the past decade have played a significant ro...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2003.10.003
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis. DESIGN:Peritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritone...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Direct effects of a gonadotropin-releasing hormone agonist (GnRHa), danazol, or estrogen/progestogen (E/P) on experimental endometriosis were evaluated in castrated female rats. Endometrial explants decreased in size following castration, but there was no further change in the treatment groups. Histologic examination ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59727-1
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To study the link between fatness and gonadotropin secretion. Overweight status is linked to polycystic ovary syndrome (PCOS) in adolescents. We postulated that heavier adolescents without symptoms would secrete LH with: [1] increased pulse frequency (LHPF) and [2] exaggerated integrated concentrations (LHAUC...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.02.072
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To assess knowledge and attitudes about infertility through a survey. DESIGN:Descriptive study with stratified random sampling. SETTING:Eighteen high schools were selected in Toronto, Ontario, Canada. PATIENT(S):Seven hundred seventy-two students participated in the study. The mean age of students was 17.5...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2007.10.024
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility and the efficacy of in vitro maturation (IVM) when immature oocyte collection was performed in the early follicular, late follicular, or luteal phases in women with cancer who require urgent chemotherapy. DESIGN:Retrospective cohort study. SETTING:University teaching hospital. P...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.09.041
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To correlate apoptosis of cultured human granulosa-lutein cells (GL cells) with the outcome of IVF (embryo fragmentation and pregnancy rate) and to study the effect of insulin and insulin-like growth factor I (IGF-I) on apoptosis. DESIGN:In vitro assays. SETTING:University laboratory and private IVF center....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.08.014
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of a sequential step-up/step-down protocol with the conventional low dose step-up and the step-down regimens in patients with polycystic ovary syndrome (PCOS) undergoing IVF. DESIGN:Prospective randomized study. SETTING:Private fertility clinic. PATIENT(S):Two hundred twenty-five, 3...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2007.06.080
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To investigate the use of preimplantation genetic diagnosis (PGD) as a method for increasing pregnancy success rates in patients at high risk for aneuploidy. DESIGN:Literature review and discussion of current evidence. CONCLUSION(S):Preimplantation genetic diagnosis selects euploid embryos for transfer in a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2005.06.045
更新日期:2006-01-01 00:00:00
abstract::Transvaginal follicular aspiration (TVA) with ultrasonically guided needles allows the transfer of in vitro generated embryos to the fallopian tubes (TET), performing only one surgical procedure in the process. Up to now, this approach has been used to treat 16 couples with infertility due to severe male factor. Folli...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60136-x
更新日期:1988-09-01 00:00:00
abstract::13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was rep...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)39196-8
更新日期:1972-09-01 00:00:00
abstract::In this prospective, randomized clinical trial, we tested the hypothesis that a needle-free CO(2) injection system (Biojector 2000) would be better tolerated by patients when compared with traditional sharp needles used for gonadotropin injections during stimulation for IVF. As measured by our questionnaire, the needl...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2009.03.013
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To systematically compare the endometrial microbiota in infertile women with and without chronic endometritis (CE), as diagnosed by a quantitative and reference range-based method. DESIGN:Case-control observational study. SETTING:University-affiliated hospital. PATIENT(S):One hundred and thirty infertile w...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2019.05.015
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To review and evaluate published studies that have assessed the effect on the skeleton of treatment with gonadotropin-releasing hormone agonists (GnRH-a). The effects on bone biochemistry and bone density are presented. DATA IDENTIFICATION:Major studies reporting on bone and GnRH-a use were identified throug...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)54948-6
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:To demonstrate the pattern(s) of spermatogonial proliferation in different spermatogenic disorders. DESIGN:Retrospective case-control study. Teaching hospital. PATIENT(S):Azoospermic men who underwent testicular biopsy for sperm recovery and preparation for intracytoplasmic sperm injection. INTERVENTION(S)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)02161-7
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. DESIGN:Clinical trial. SETTING:Reproductive unit of a university teaching hospital. PATIENT:A patient of obstructive azoospermia with defective spermiogenesis. INTERVENTION:Testicular biopsy after scrotal exploration...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)58406-4
更新日期:1996-07-01 00:00:00
abstract::A liquefraction factor from normal human seminal plasma was purified by cation and anion exchange chromatography. It is nondialyzable, heat-labile, and has many properties in common with the seminal protease "chymotrypsin-like enzyme." Its lytic effect is most distinctly observed in abnormal semen that is semisolid or...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)41471-8
更新日期:1975-11-01 00:00:00
abstract::Fifty-one female volunteers used a superactive stimulatory luteinizing hormone-releasing hormone (LH-RH) analog for suppression of ovulation for 3 to 12 months. The potent LH-RH agonist D-Ser(TBU)6-EA10-LH-RH was administered intranasally once daily in a dose of 400 or 600 micrograms. No pregnancies occurred during th...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract::There is good evidence of an associated abnormality in testicular hormone production and spermatogenesis in some men with varicoceles. This abnormality can be demonstrated with dynamic tests of the hypothalamic-pituitary-testicular axis and by measuring seminal plasma androgen levels. A high proportion of oligozoosper...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)59700-3
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles. DESIGN:Prospective pilot study. SETTING:One university hospital and two private infertility clinics. PATIENT(S):Ninety-three infertile couples eligible for superov...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.02.070
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Since little is known about the actual incidence and fate of vacuoles at different stages of development this preliminary study was set up to accurately measure vacuoles and track them to day 5. DESIGN:Prospective study. SETTING:Women's General Hospital in Austria. PATIENT(S):A total of 223 consecutive IVF...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.02.009
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To describe the obstetric performance of a selected population of twin pregnancies, comparing reduced vs. nonreduced twin pregnancies after the successful completion of the 12th week. DESIGN:Prospective cohort study. SETTING:Outpatient fertility center. PATIENT(S):A cohort of 464 twin pregnancies including...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.09.005
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). DESIGN:Cohort. SETTING:Academic practice. PATIENT(S):A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects. INTERVENTION(S):Blood and ovarian ultras...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.06.017
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine intrafollicular hormone levels and characterize the mRNA expression of the insulin-like growth factor (IGF) receptors, IGF binding proteins (IGFBP), and pregnancy-associated plasma protein-A (PAPP-A) in granulosa cells before and after an ovulatory hCG stimulus. DESIGN:Experimental animal study....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.096
更新日期:2010-03-15 00:00:00