Abstract:
:In mycobacteria, iron dependent transcription regulator (IdeR) regulates transcription of genes in response to iron levels. The IdeR regulated genes have been investigated mostly in M. tuberculosis, M. smegmatis, and in few of the other related species. Recent advances in crystal structure solution and computational as well as experimental identification of IdeR targets has provided insight into IdeR structure and function. Here in this review we take stock of current state of knowledge on IdeR and its targets to understand the underlying design of the IdeR regulon and its role in mycobacterial physiology.
journal_name
Crit Rev Microbioljournal_title
Critical reviews in microbiologyauthors
Ranjan S,Yellaboina S,Ranjan Adoi
10.1080/10408410600709768subject
Has Abstractpub_date
2006-01-01 00:00:00pages
69-75issue
2eissn
1040-841Xissn
1549-7828pii
RG4006P337P2411Ujournal_volume
32pub_type
杂志文章,评审abstract::Cyclic AMP is a ubiquitous messenger that integrates many processes of the cell. Diverse families of adenylate cyclases and phosphodiesterases stringently regulate the intracellular concentration of cAMP. Any alteration in the cytosolic concentration of cAMP has a profound effect on the various processes of the cell. ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410490468795
更新日期:2004-01-01 00:00:00
abstract::Escherichia coli can commonly be found, either as a commensal, probiotic or a pathogen, in the human gastrointestinal (GI) tract. Biofilm formation and its regulation is surprisingly variable, although distinct regulatory pattern of red, dry and rough (rdar) biofilm formation arise in certain pathovars and even clones...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2017.1303660
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abstract::Renewed interest in the acetone-butanol-ethanol (ABE) fermentation as a route for industrial production of butanol has been evident since the oil crisis of the 1970s. The present review includes an historical recap of the traditional industrial process and culturing practices useful in maintaining viable solvent-produ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418809104464
更新日期:1988-01-01 00:00:00
abstract::Bacterial populations that are exposed to rapidly changing and sometimes hostile environments constantly switch between growth, survival, and death. Understanding bacterial survival and death are therefore cornerstones in a full comprehension of microbial life. During the last few years, new insights have emerged rega...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410490884757
更新日期:2004-01-01 00:00:00
abstract::Tuberculosis (TB) is an air-born, transmissible disease, having an estimated 9.4 million new TB cases worldwide in 2009. Eventual control of this disease by developing a safe and efficient new vaccine able to detain its spread will have an enormous impact on public health policy. Selecting potential antigens to be inc...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.763221
更新日期:2014-05-01 00:00:00
abstract::Giardia lamblia is the causative agent of the diarrheal disease giardiasis, against which only a limited number of drugs are currently available. Increasing reports of resistance to these drugs makes it necessary to identify new cellular targets for designing the next generation of anti-giardial drugs. Towards this go...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2016.1262814
更新日期:2017-08-01 00:00:00
abstract::The numbers and diversity of microbes in ecosystems within and around us is unmatched, yet most of these microorganisms remain recalcitrant to in vitro cultivation. Various high-throughput molecular techniques, collectively termed multi-omics, provide insights into the genomic structure and metabolic potential as well...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2017.1332003
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abstract::It is clear that mannan has the potential to influence multiple biologic functions in vivo and in vitro, including both mannan-specific and mannan-nonspecific activities. Based on in vitro studies, various mechanisms have been proposed for the regulatory activities observed, ranging from interference with normal PMNL ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418909105721
更新日期:1989-01-01 00:00:00
abstract::The use of successive generations of beta-lactams has selected successive generations of beta-lactamases including CTX-M ESBLs, AmpC beta-lactamases, and KPC carbapenamases in Enterobacteriaceae. Moreover, this cephalosporin resistance, along with rising resistance to fluoroquinolones, is now driving the use of carbap...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410902733979
更新日期:2009-01-01 00:00:00
abstract::The human fungal pathogen Candida albicans switches from a budding yeast form to a polarized hyphal form in response to various external signals. This morphogenetic switching has been implicated in the development of pathogenicity. Several signaling pathways that regulate morphogenesis have been identified, including ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/713610451
更新日期:2003-01-01 00:00:00
abstract::Escherichia coli enterotoxigenic strains produce one or more toxins which action result in production of diarrhea in animals including Man. One of these toxins, STb, has been mainly associated with colibacillosis in swine. Although highly prevalent in pigs with diarrhea, a relation between STb and disease was arduous ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408411003720191
更新日期:2010-08-01 00:00:00
abstract::Industrialisation has introduced several lifestyle changes and medical advancements but their impact on intestinal microbiota acquisition is often overlooked. Even though these consequential changes in the microbiota could contribute to the disease burden that accompanies industrialisation, such as obesity and atopic ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2019.1680601
更新日期:2019-01-01 00:00:00
abstract::Pneumococcal surface adhesin A (PsaA) is a surface-exposed common 37-kilodalton multi-functional lipoprotein detected on all known serotypes of Streptococcus pneumoniae. This lipoprotein belongs to the ABC-type transport protein complex that transports Mn2+; it is also an adhesin that plays a major role in pneumococca...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410802275352
更新日期:2008-01-01 00:00:00
abstract::The environmental health-related relevance of cyanobacteria is primarily related to their ability to produce a wide range of toxins, which are known to be hazardous to many organisms, including human beings. The occurrence of cyanobacterial blooms has been related to eutrophic surface water. In the bloom-forming proce...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410600822934
更新日期:2006-01-01 00:00:00
abstract::The bacteria having a unique ring-like morphology first isolated from nasal mucus by Weibel in 1887 were classified as a new genus Spirosoma by Migula in 1894. However, because these bacteria were not completely described for taxonomic purposes and their cultures were no longer available, the genus was deleted from th...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408419009114761
更新日期:1990-01-01 00:00:00
abstract::Staphylococcus aureus biofilms represent a unique micro-environment that directly contribute to the bacterial fitness within hospital settings. The accumulation of this structure on implanted medical devices has frequently caused the development of persistent and chronic S. aureus-associated infections, which represen...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2017.1282941
更新日期:2017-09-01 00:00:00
abstract::The use of phages to control and reduce numbers of unwanted bacteria can be traced back to the early 1900s, when phages were explored as a tool to treat infections before the wide scale use of antibiotics. Recently, phage therapy has received renewed interest as a method to treat multiresistant bacteria. Phages are al...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2015.1114466
更新日期:2016-11-01 00:00:00
abstract::Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topica...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2017.1313811
更新日期:2018-02-01 00:00:00
abstract::Although bacteria have historically been considered to play a major role in cystic fibrosis (CF) airway damage, a strong impact of respiratory viral infections (RVI) is also now recognized. Emerging evidence confirms that respiratory viruses are associated with deterioration of pulmonary function and exacerbation and ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2017.1297763
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abstract::Following a brief review of the ecology of Escherichia coli in general, the role of Shiga-Toxigenic (Verocytotoxigenic) E. coli (STEC) as pathogens is addressed. While STEC belonging to the serogroup O157 have been extensively studied and shown to be involved in many cases and outbreaks of human disease, the importanc...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410601172172
更新日期:2007-01-01 00:00:00
abstract::The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of different residential microflora. The physiological changes that occur during pregnancy may disrupt this balanced ecosystem and predispose women to a potentially pathogenic microbiota. Bacteria that are associated with bacterial v...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2014.954522
更新日期:2016-05-01 00:00:00
abstract::Highly significant evidence of the intellectual and cultural efforts of the human race is contained in documents. They take many forms, from papyri through paper to modern magnetic media and optical records. These items are mainly made of organic materials many of which contain polymers, which span from cellulose and ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410490884766
更新日期:2005-01-01 00:00:00
abstract::Nanotechnology, the engineering and art of manipulating matter at the nanoscale (1-100 nm), offers the potential of novel nanomaterials for treatment of surface water, groundwater, and wastewater contaminated by toxic metal ions, organic and inorganic solutes, and microorganisms. Due to their unique activity toward re...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410701710442
更新日期:2008-01-01 00:00:00
abstract::Biofilms are complex microbial architectures that encase microbial cells in a matrix comprising self-produced extracellular polymeric substances. Microorganisms living in biofilms are much more resistant to hostile environments than their planktonic counterparts and exhibit enhanced resistance against the microbicides...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章
doi:10.1080/1040841X.2020.1842325
更新日期:2020-12-28 00:00:00
abstract::Tuberculosis is an ancient human scourge that continues to be an important public health problem worldwide. The increasing number of multidrug-resistant (MDR) M. tuberculosis isolates from both AIDS and non-AIDS patients is an ominous trend that threatens tuberculosis eradication programs both in the U.S. and overseas...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408419309113520
更新日期:1993-01-01 00:00:00
abstract::Macrophomina phaseolina (Tassi) Goid. is an important phytopathogenic fungus, infecting a large number of plant species and surviving for up to 15 years in the soil as a saprophyte. Although considerable research related to the biology and ecology of Macrophomina has been conducted, it continues to cause huge economic...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2011.640977
更新日期:2012-05-01 00:00:00
abstract::The increasing emergence of antimicrobial multiresistant bacteria is of great concern to public health. While these bacteria are becoming an ever more prominent cause of nosocomial and community-acquired infections worldwide, the antibiotic discovery pipeline has been stalled in the last few years with very few effort...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.866073
更新日期:2015-01-01 00:00:00
abstract::This review followed from experiments suggesting that some fungi do not require calcium. It was found that many studies of a calcium requirement in microorganisms had assumed specificity for chelation agents such as EGTA and A23187, which the reagents did not possess. Early studies still cited today often preceded the...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408419309113524
更新日期:1993-01-01 00:00:00
abstract::Urease activity is a physiological function of many bacteria that enables these organisms to utilize urea as a source of nitrogen. The association of ureolytic bacteria with human or animal hosts varies widely from a commensal relationship as demonstrated with skin microflora, a symbiotic relationship in the gastroint...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418809104467
更新日期:1988-01-01 00:00:00
abstract::T-cells play an important role in immunity but when these cells are overexposed to specific antigens, their function may decline. This state is usually referred to as exhaustion and the T-cells show reduced proliferation and functions such as cytokine release. T-cell exhaustion has been observed in several cancers as ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2016.1185603
更新日期:2017-03-01 00:00:00