IdeR in mycobacteria: from target recognition to physiological function.

Abstract:

:In mycobacteria, iron dependent transcription regulator (IdeR) regulates transcription of genes in response to iron levels. The IdeR regulated genes have been investigated mostly in M. tuberculosis, M. smegmatis, and in few of the other related species. Recent advances in crystal structure solution and computational as well as experimental identification of IdeR targets has provided insight into IdeR structure and function. Here in this review we take stock of current state of knowledge on IdeR and its targets to understand the underlying design of the IdeR regulon and its role in mycobacterial physiology.

journal_name

Crit Rev Microbiol

authors

Ranjan S,Yellaboina S,Ranjan A

doi

10.1080/10408410600709768

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

69-75

issue

2

eissn

1040-841X

issn

1549-7828

pii

RG4006P337P2411U

journal_volume

32

pub_type

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