Viruses in cystic fibrosis patients' airways.

Abstract:

:Although bacteria have historically been considered to play a major role in cystic fibrosis (CF) airway damage, a strong impact of respiratory viral infections (RVI) is also now recognized. Emerging evidence confirms that respiratory viruses are associated with deterioration of pulmonary function and exacerbation and facilitation of bacterial colonization in CF patients. The aim of this review is to provide an overview of the current knowledge on respiratory viruses in CF airways, to discuss the resulting inflammation and RVI response, to determine how to detect the viruses, and to assess their clinical consequences, prevalence, and interactions with bacteria. The most predominant are Rhinoviruses (RVs), significantly associated with CF exacerbation. Molecular techniques, and especially multiplex PCR, help to diagnose viral infections, and the coming rise of metagenomics will extend knowledge of viral populations in the complex ecosystem of CF airways. Prophylaxis and vaccination are currently available only for Respiratory syncytial and Influenza virus (IV), but antiviral molecules are being tested to improve CF patients' care. All the points raised in this review highlight the importance of taking account of RVIs and their potential impact on the CF airway ecosystem.

journal_name

Crit Rev Microbiol

authors

Billard L,Le Berre R,Pilorgé L,Payan C,Héry-Arnaud G,Vallet S

doi

10.1080/1040841X.2017.1297763

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

690-708

issue

6

eissn

1040-841X

issn

1549-7828

journal_volume

43

pub_type

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