Implication of virulence factors in Escherichia coil O157:H7 pathogenesis.

Abstract:

:Since the first documented outbreak of hemorrhagic colitis caused by Escherichia coli O157:H7 in 1982, numerous publications have demonstrated or proposed putative components implicated in the pathogenesis of this gastrointestinal infection. Indeed, Escherichia coli O157:H7 pathogenesis is linked to several potential virulent factors such as verotoxins (or Shiga-like toxins), components implicated in attaching/effacing of microvilli, and the enterohemolysin phenotypes. Defining the precise molecular mechanisms involved in the pathogenesis of E. coli O157:H7 implies detailed comprehension of the virulent factors that provoke a wide range of pathophysiological symptoms. The public health significance of this emerging world-wide menace has been demonstrated by clinical complications during treatment, its low infectious dose, and the severity of clinical manifestations. In this review I describe current knowledge of Escherichia coli O157:H7 pathogenesis with emphasis on known and potential virulent factors.

journal_name

Crit Rev Microbiol

authors

LeBlanc JJ

doi

10.1080/713608014

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

277-96

issue

4

eissn

1040-841X

issn

1549-7828

journal_volume

29

pub_type

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