The role of viral infections in the development of autoimmune diseases.

Abstract:

:The exact aetiology of most autoimmune diseases remains unknown, nonetheless, several factors contributing to the induction or exacerbation of autoimmune reactions have been suggested. These include the genetic profile and lifestyle of the affected individual in addition to environmental triggers such as bacterial, parasitic, fungal and viral infections. Infections caused by viruses usually trigger a potent immune response that is necessary for the containment of the infection; however, in some cases, a failure in the regulation of this immune response may lead to harmful immune reactions directed against the host's antigens. The autoimmune attack can be carried out by different arms and components of the immune system and through different possible mechanisms including molecular mimicry, bystander activation, and epitope spreading among others. In this review, we examine the data available for the involvement of viral infections in triggering or exacerbating autoimmune diseases in addition to discussing the mechanisms by which these viral infections and the immune pathways they trigger possibly contribute to the development of autoimmunity.

journal_name

Crit Rev Microbiol

authors

Hussein HM,Rahal EA

doi

10.1080/1040841X.2019.1614904

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

394-412

issue

4

eissn

1040-841X

issn

1549-7828

journal_volume

45

pub_type

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