Abstract:
:The use of successive generations of beta-lactams has selected successive generations of beta-lactamases including CTX-M ESBLs, AmpC beta-lactamases, and KPC carbapenamases in Enterobacteriaceae. Moreover, this cephalosporin resistance, along with rising resistance to fluoroquinolones, is now driving the use of carbapenems and unfortunately the carbapenem resistance has emerged markedly, especially in Acinetobacter spp. due to OXA- and metallo-carbapenemases. The industry responded to the challenge of rising resistance and recently developed some novel beta-lactams such as ceftobiprole, ceftaroline etc. and many beta-lactam compounds, including beta-lactamase-inhibitors, such as BMS-247243, S-3578, RWJ-54428, CS-023, SMP-601, NXL 104, BAL 30376, LK 157, and so on are under trials. This review provides the comprehensive accounts of the developments in penicillins, cephalosporins, carbapenems, and beta-lactamase-inhibitors, and the insight about medicinal chemistry, mechanism(s) of action and resistance, potential strategies to overcome resistance due to beta-lactamases, and also the recent advancements in the development of newer beta-lactam compounds; some of which are still under trials and yet to be classified. This review will fill the gap since previously published reviews and will serve as a comprehensive update on the current topic.
journal_name
Crit Rev Microbioljournal_title
Critical reviews in microbiologyauthors
Shahid M,Sobia F,Singh A,Malik A,Khan HM,Jonas D,Hawkey PMdoi
10.1080/10408410902733979subject
Has Abstractpub_date
2009-01-01 00:00:00pages
81-108issue
2eissn
1040-841Xissn
1549-7828journal_volume
35pub_type
杂志文章,评审abstract::Cyclic AMP is a ubiquitous messenger that integrates many processes of the cell. Diverse families of adenylate cyclases and phosphodiesterases stringently regulate the intracellular concentration of cAMP. Any alteration in the cytosolic concentration of cAMP has a profound effect on the various processes of the cell. ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410490468795
更新日期:2004-01-01 00:00:00
abstract::Tuberculosis (TB) is an air-born, transmissible disease, having an estimated 9.4 million new TB cases worldwide in 2009. Eventual control of this disease by developing a safe and efficient new vaccine able to detain its spread will have an enormous impact on public health policy. Selecting potential antigens to be inc...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.763221
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abstract::A chronically weak area in research papers, reports, and reviews is the complete identification of important background reference documents that formed the building blocks for the research. A method for systematically determining these important references is presented. Citation-Assisted Background (CAB) is based on t...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2010.484002
更新日期:2010-11-01 00:00:00
abstract::Nanotechnology, the engineering and art of manipulating matter at the nanoscale (1-100 nm), offers the potential of novel nanomaterials for treatment of surface water, groundwater, and wastewater contaminated by toxic metal ions, organic and inorganic solutes, and microorganisms. Due to their unique activity toward re...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410701710442
更新日期:2008-01-01 00:00:00
abstract::Riboflavin derivatives are essential cofactors for a myriad of flavoproteins. In bacteria, flavins importance extends beyond their role as intracellular protein cofactors, as secreted flavins are a key metabolite in a variety of physiological processes. Bacteria obtain riboflavin through the endogenous riboflavin bios...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2016.1192578
更新日期:2017-03-01 00:00:00
abstract::The human fungal pathogen Candida albicans switches from a budding yeast form to a polarized hyphal form in response to various external signals. This morphogenetic switching has been implicated in the development of pathogenicity. Several signaling pathways that regulate morphogenesis have been identified, including ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/713610451
更新日期:2003-01-01 00:00:00
abstract::This review followed from experiments suggesting that some fungi do not require calcium. It was found that many studies of a calcium requirement in microorganisms had assumed specificity for chelation agents such as EGTA and A23187, which the reagents did not possess. Early studies still cited today often preceded the...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408419309113524
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abstract::The environmental health-related relevance of cyanobacteria is primarily related to their ability to produce a wide range of toxins, which are known to be hazardous to many organisms, including human beings. The occurrence of cyanobacterial blooms has been related to eutrophic surface water. In the bloom-forming proce...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410600822934
更新日期:2006-01-01 00:00:00
abstract::The bacterial cell cycle is simpler and different than that of the typical eukaryotic cell cycle. The selective pressure during evolution has been directed to achieve optimal growth of the individual free-living microbial cell instead of a variety of replication rates of the differentiated cell within an entire multic...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
abstract::A pheromone is a chemical excreted by an organism into the environment that acts to elicit a specific response from other organisms of the same species. The importance of pheromones in the life cycle of various species of mammals, insects, and fungi is well known. In the past decade, it has become apparent that pherom...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418609108741
更新日期:1986-01-01 00:00:00
abstract::Mycobacteria are endowed with substances that profoundly affect the immune system. Leprosy and tuberculosis exemplify broad spectra of useful and detrimental immune responses of mycobacterial infections that range from intense potentiation to severe specific adn nonspecific suppression of humoral and cellular immune e...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418209104488
更新日期:1982-01-01 00:00:00
abstract::The brucellae are α-Proteobacteria causing brucellosis, an important zoonosis. Although multiplying in endoplasmic reticulum-derived vacuoles, they cause no cell death, suggesting subtle but efficient use of host resources. Brucellae are amino-acid prototrophs able to grow with ammonium or use glutamate as the sole ca...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2014.962480
更新日期:2016-08-01 00:00:00
abstract::The use of marine microorganisms as potential biofactories for green synthesis of metallic nanoparticles is a relatively new field of research with considerable prospects. This method is eco-friendly, time saving, and inexpensive and can be easily scaled up for large-scale synthesis. The increasing need to develop sim...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2015.1137860
更新日期:2016-11-01 00:00:00
abstract::The cyanobacteria (blue-green algae) are photosynthetic prokaryotes having applications in human health with numerous biological activities and as a dietary supplement. It is used as a food supplement because of its richness in nutrients and digestibility. Many cyanobacteria (Microcystis sp, Anabaena sp, Nostoc sp, Os...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2014.957640
更新日期:2016-05-01 00:00:00
abstract::The increasing emergence of antimicrobial multiresistant bacteria is of great concern to public health. While these bacteria are becoming an ever more prominent cause of nosocomial and community-acquired infections worldwide, the antibiotic discovery pipeline has been stalled in the last few years with very few effort...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.866073
更新日期:2015-01-01 00:00:00
abstract::Since the first documented outbreak of hemorrhagic colitis caused by Escherichia coli O157:H7 in 1982, numerous publications have demonstrated or proposed putative components implicated in the pathogenesis of this gastrointestinal infection. Indeed, Escherichia coli O157:H7 pathogenesis is linked to several potential ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/713608014
更新日期:2003-01-01 00:00:00
abstract::Toxin-antitoxin (TA) systems consist of a bicistronic operon, encoding a toxin and an antitoxin. They are widely distributed in the prokaryotic kingdom, often in multiple numbers. TAs are implicated in contradicting phenomena of persistence and programmed cell death (PCD) in bacteria. mazEF TA system, one of the widel...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.804030
更新日期:2015-02-01 00:00:00
abstract::Renewed interest in the acetone-butanol-ethanol (ABE) fermentation as a route for industrial production of butanol has been evident since the oil crisis of the 1970s. The present review includes an historical recap of the traditional industrial process and culturing practices useful in maintaining viable solvent-produ...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418809104464
更新日期:1988-01-01 00:00:00
abstract::There is an increasing interest in non-albicans Candida species because of the increasing number of fungal infections they cause. Most of these infections can be found in immunocompromised individuals, especially in those infected with human immunodeficiency virus (HIV). Candida dubliniensis is a recently identified y...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410091154183
更新日期:2000-01-01 00:00:00
abstract::Within Gram-positive bacteria, the expression of target genes is controlled at the population level via signaling peptides, also known as pheromones. Pheromones control a wide range of functions, including competence, virulence, and others that remain unknown. Until now, their role in bacterial gene regulation has pro...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2014.948804
更新日期:2016-05-01 00:00:00
abstract::Following a brief review of the ecology of Escherichia coli in general, the role of Shiga-Toxigenic (Verocytotoxigenic) E. coli (STEC) as pathogens is addressed. While STEC belonging to the serogroup O157 have been extensively studied and shown to be involved in many cases and outbreaks of human disease, the importanc...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408410601172172
更新日期:2007-01-01 00:00:00
abstract::There are difficult technical problems inherent in verifying compliance to the Biological Weapons and Toxin Convention (BWC) that are making it difficult to reach international agreement on a verification protocol. A compliance regime will most likely involve the formation of an Organization for the Prevention of Biol...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/10408419891294262
更新日期:1998-01-01 00:00:00
abstract::With the increase in antibiotic-resistant bacteria and the lack of new antibiotics being brought onto the market, alternative strategies need to be found to cope with infections resulting from drug-resistant bacteria. A possible solution may be to combine existing antibiotics with phytochemicals to enhance the efficac...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.763219
更新日期:2014-02-01 00:00:00
abstract::In terms of genetically determined susceptibility to the clinical antifungal agent 5-fluorocytosine (5-FC), Candida albicans may be homozygous sensitive (FCY/FCY), homozygous resistant (fcy/fcy), or heterozygous (fcy/FCY). Although heterozygotes are only slightly resistant, they occur at significant frequency among cl...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408418709104447
更新日期:1987-01-01 00:00:00
abstract::The cell wall of Saccharomyces cerevisiae is an extracellular organelle crucial for preserving its cellular integrity and detecting environmental cues. The cell wall is composed of mannoproteins attached to a polysaccharide network and is continuously remodelled as cells undergo cell division, mating, gametogenesis or...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2020.1715340
更新日期:2020-02-01 00:00:00
abstract::Lectins are natural bioactive ubiquitous proteins or glycoproteins of non-immune response that bind reversibly to glycans of glycoproteins, glycolipids and polysaccharides possessing at least one non-catalytic domain causing agglutination. Some of them consist of several carbohydrate-binding domains which endow them w...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/1040841X.2013.798780
更新日期:2015-02-01 00:00:00
abstract::The ability of serum complement to kill bacteria has been linked to host resistance to Gram-negative bacteria. A mechanism for killing extracellular organisms during early invasion, following release from infected phagocytic cells, or during bacteremia would contribute to a host's ability to resist disease. In fact, t...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408419509113538
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abstract::Dermatophytoses are superficial infections caused by a group of fungi, the dermatophytes, which invade keratinized tissue of skin, hair, and nails in humans and animals. The importance of normal immune function in resistance to dermatophytoses is substantiated by an increased susceptibility to chronic infection seen i...
journal_title:Critical reviews in microbiology
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abstract::Tuberculosis is an ancient human scourge that continues to be an important public health problem worldwide. The increasing number of multidrug-resistant (MDR) M. tuberculosis isolates from both AIDS and non-AIDS patients is an ominous trend that threatens tuberculosis eradication programs both in the U.S. and overseas...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.3109/10408419309113520
更新日期:1993-01-01 00:00:00
abstract::Eugenol is a hydroxyphenyl propene, naturally occurring in the essential oils of several plants belonging to the Lamiaceae, Lauraceae, Myrtaceae, and Myristicaceae families. It is one of the major constituents of clove (Syzygium aromaticum (L.) Merr. & L.M. Perry, Myrtaceae) oil and is largely used in both foods and c...
journal_title:Critical reviews in microbiology
pub_type: 杂志文章,评审
doi:10.1080/1040841X.2017.1295225
更新日期:2017-11-01 00:00:00